Information flow, cell types and stereotypy in a full olfactory connectome

The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated th...

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Autores principales:	Philipp Schlegel, Alexander Shakeel Bates, Tomke Stürner, Sridhar R Jagannathan, Nikolas Drummond, Joseph Hsu, Laia Serratosa Capdevila, Alexandre Javier, Elizabeth C Marin, Asa Barth-Maron, Imaan FM Tamimi, Feng Li, Gerald M Rubin, Stephen M Plaza, Marta Costa, Gregory S X E Jefferis
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	connectomics olfaction stereotypy neuroanatomy synapses Drosophila Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4aa17a1a53454217bbf09a8d2f0ecbe7
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spelling	oai:doaj.org-article:4aa17a1a53454217bbf09a8d2f0ecbe72021-11-14T14:47:18ZInformation flow, cell types and stereotypy in a full olfactory connectome10.7554/eLife.660182050-084Xe66018https://doaj.org/article/4aa17a1a53454217bbf09a8d2f0ecbe72021-05-01T00:00:00Zhttps://elifesciences.org/articles/66018https://doaj.org/toc/2050-084XThe hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated third-order neurons. We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs, mapping olfactory input to descending interneurons. This identifies a range of motifs including highly lateralised circuits in the antennal lobe and patterns of convergence downstream of the mushroom body and lateral horn. Leveraging a second data set we provide a first quantitative assessment of inter- versus intra-individual stereotypy. Comparing neurons across two brains (three hemispheres) reveals striking similarity in neuronal morphology across brains. Connectivity correlates with morphology and neurons of the same morphological type show similar connection variability within the same brain as across two brains.Philipp SchlegelAlexander Shakeel BatesTomke StürnerSridhar R JagannathanNikolas DrummondJoseph HsuLaia Serratosa CapdevilaAlexandre JavierElizabeth C MarinAsa Barth-MaronImaan FM TamimiFeng LiGerald M RubinStephen M PlazaMarta CostaGregory S X E JefferiseLife Sciences Publications LtdarticleconnectomicsolfactionstereotypyneuroanatomysynapsesDrosophilaMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	connectomics olfaction stereotypy neuroanatomy synapses Drosophila Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	connectomics olfaction stereotypy neuroanatomy synapses Drosophila Medicine R Science Q Biology (General) QH301-705.5 Philipp Schlegel Alexander Shakeel Bates Tomke Stürner Sridhar R Jagannathan Nikolas Drummond Joseph Hsu Laia Serratosa Capdevila Alexandre Javier Elizabeth C Marin Asa Barth-Maron Imaan FM Tamimi Feng Li Gerald M Rubin Stephen M Plaza Marta Costa Gregory S X E Jefferis Information flow, cell types and stereotypy in a full olfactory connectome
description	The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated third-order neurons. We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs, mapping olfactory input to descending interneurons. This identifies a range of motifs including highly lateralised circuits in the antennal lobe and patterns of convergence downstream of the mushroom body and lateral horn. Leveraging a second data set we provide a first quantitative assessment of inter- versus intra-individual stereotypy. Comparing neurons across two brains (three hemispheres) reveals striking similarity in neuronal morphology across brains. Connectivity correlates with morphology and neurons of the same morphological type show similar connection variability within the same brain as across two brains.
format	article
author	Philipp Schlegel Alexander Shakeel Bates Tomke Stürner Sridhar R Jagannathan Nikolas Drummond Joseph Hsu Laia Serratosa Capdevila Alexandre Javier Elizabeth C Marin Asa Barth-Maron Imaan FM Tamimi Feng Li Gerald M Rubin Stephen M Plaza Marta Costa Gregory S X E Jefferis
author_facet	Philipp Schlegel Alexander Shakeel Bates Tomke Stürner Sridhar R Jagannathan Nikolas Drummond Joseph Hsu Laia Serratosa Capdevila Alexandre Javier Elizabeth C Marin Asa Barth-Maron Imaan FM Tamimi Feng Li Gerald M Rubin Stephen M Plaza Marta Costa Gregory S X E Jefferis
author_sort	Philipp Schlegel
title	Information flow, cell types and stereotypy in a full olfactory connectome
title_short	Information flow, cell types and stereotypy in a full olfactory connectome
title_full	Information flow, cell types and stereotypy in a full olfactory connectome
title_fullStr	Information flow, cell types and stereotypy in a full olfactory connectome
title_full_unstemmed	Information flow, cell types and stereotypy in a full olfactory connectome
title_sort	information flow, cell types and stereotypy in a full olfactory connectome
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/4aa17a1a53454217bbf09a8d2f0ecbe7
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Information flow, cell types and stereotypy in a full olfactory connectome

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