Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials

Haohai Huang,1 Dan Liao,2 Yong Dong,3 Rong Pu41Department of Clinical Pharmacy, Dongguan Third People’s Hospital, Affiliated Dongguan Shilong People’s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of China; 2Department of Gynaecology, D...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huang H, Liao D, Dong Y, Pu R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Quercetin Body weight Obesity Overweight Meta-Analysis Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/4aa4260dda9444c5a84003f6f310e4d4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4aa4260dda9444c5a84003f6f310e4d4
record_format	dspace
spelling	oai:doaj.org-article:4aa4260dda9444c5a84003f6f310e4d42021-12-02T03:57:30ZClinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials1178-7007https://doaj.org/article/4aa4260dda9444c5a84003f6f310e4d42019-04-01T00:00:00Zhttps://www.dovepress.com/clinical-effectiveness-of-quercetin-supplementation-in-the-management--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Haohai Huang,1 Dan Liao,2 Yong Dong,3 Rong Pu41Department of Clinical Pharmacy, Dongguan Third People’s Hospital, Affiliated Dongguan Shilong People’s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of China; 2Department of Gynaecology, Dongguan Third People’s Hospital, Affiliated Dongguan Shilong People’s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of China; 3Department of Cancer Center, Dongguan Third People‘s Hospital, Affiliated Dongguan Shilong People’s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of China; 4Department of Clinical Laboratory, Dongguan Third People’s Hospital, Affiliated Dongguan Shilong People‘s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of ChinaPurpose: The previous investigations which considered the possible effect of the quercetin supplementation for overweight and obesity have led to inconsistent results. Here, we aimed to evaluate the effects of quercetin on weight loss using a meta-analysis of randomized controlled clinical trials (RCTs).Methods: Relevant studies were systematically searched from the MEDLINE, EMBASE, Google Scholar, and Scopus databases. RCTs that investigated the effects of quercetin on weight loss in humans were included for quality assessment, meta-analyses, sensitivity analysis, subgroup analyses, and publication bias assessment. Effect size was expressed as weighted mean difference (WMD) and 95% CI by using a random-effects model. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to rate the level of evidence.Results: Nine RCTs (11 treatment arms) with 525 participants were finally included for data pooling. Our meta-analysis revealed that daily quercetin supplementation did not significantly affect the body weight (WMD: −0.35 kg, 95% CI: −2.03, 1.33; P=0.68), body mass index (WMD: −0.04 kg/m2 95% CI: −0.54, 0.45; P=0.87), waist circumference (WMD: −0.37 cm, 95% CI: −1.81, 1.06; P=0.61), and waist to hip ratio (WMD: −0.01, 95% CI: −0.03, 0.01; P=0.48). Subgroup analysis could not identify factors significantly influencing these parameters. These results were robust in sensitivity analysis, and no significant publication bias was found.Conclusion: The current evidence suggests that quercetin intake did not show a notably favorable effect on weight loss. Future well-designed and long-term clinical trials are required to confirm these results.Keywords: quercetin, body weight, obesity, overweight, meta-analysisHuang HLiao DDong YPu RDove Medical PressarticleQuercetinBody weightObesityOverweightMeta-AnalysisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 553-563 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Quercetin Body weight Obesity Overweight Meta-Analysis Specialties of internal medicine RC581-951
spellingShingle	Quercetin Body weight Obesity Overweight Meta-Analysis Specialties of internal medicine RC581-951 Huang H Liao D Dong Y Pu R Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials
description	Haohai Huang,1 Dan Liao,2 Yong Dong,3 Rong Pu41Department of Clinical Pharmacy, Dongguan Third People’s Hospital, Affiliated Dongguan Shilong People’s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of China; 2Department of Gynaecology, Dongguan Third People’s Hospital, Affiliated Dongguan Shilong People’s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of China; 3Department of Cancer Center, Dongguan Third People‘s Hospital, Affiliated Dongguan Shilong People’s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of China; 4Department of Clinical Laboratory, Dongguan Third People’s Hospital, Affiliated Dongguan Shilong People‘s Hospital of Southern Medical University, Dongguan, Guangdong, People’s Republic of ChinaPurpose: The previous investigations which considered the possible effect of the quercetin supplementation for overweight and obesity have led to inconsistent results. Here, we aimed to evaluate the effects of quercetin on weight loss using a meta-analysis of randomized controlled clinical trials (RCTs).Methods: Relevant studies were systematically searched from the MEDLINE, EMBASE, Google Scholar, and Scopus databases. RCTs that investigated the effects of quercetin on weight loss in humans were included for quality assessment, meta-analyses, sensitivity analysis, subgroup analyses, and publication bias assessment. Effect size was expressed as weighted mean difference (WMD) and 95% CI by using a random-effects model. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to rate the level of evidence.Results: Nine RCTs (11 treatment arms) with 525 participants were finally included for data pooling. Our meta-analysis revealed that daily quercetin supplementation did not significantly affect the body weight (WMD: −0.35 kg, 95% CI: −2.03, 1.33; P=0.68), body mass index (WMD: −0.04 kg/m2 95% CI: −0.54, 0.45; P=0.87), waist circumference (WMD: −0.37 cm, 95% CI: −1.81, 1.06; P=0.61), and waist to hip ratio (WMD: −0.01, 95% CI: −0.03, 0.01; P=0.48). Subgroup analysis could not identify factors significantly influencing these parameters. These results were robust in sensitivity analysis, and no significant publication bias was found.Conclusion: The current evidence suggests that quercetin intake did not show a notably favorable effect on weight loss. Future well-designed and long-term clinical trials are required to confirm these results.Keywords: quercetin, body weight, obesity, overweight, meta-analysis
format	article
author	Huang H Liao D Dong Y Pu R
author_facet	Huang H Liao D Dong Y Pu R
author_sort	Huang H
title	Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials
title_short	Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials
title_full	Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials
title_fullStr	Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials
title_full_unstemmed	Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials
title_sort	clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/4aa4260dda9444c5a84003f6f310e4d4
work_keys_str_mv	AT huangh clinicaleffectivenessofquercetinsupplementationinthemanagementofweightlossapooledanalysisofrandomizedcontrolledtrials AT liaod clinicaleffectivenessofquercetinsupplementationinthemanagementofweightlossapooledanalysisofrandomizedcontrolledtrials AT dongy clinicaleffectivenessofquercetinsupplementationinthemanagementofweightlossapooledanalysisofrandomizedcontrolledtrials AT pur clinicaleffectivenessofquercetinsupplementationinthemanagementofweightlossapooledanalysisofrandomizedcontrolledtrials
_version_	1718401545886760960

Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials

Ejemplares similares