Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

QR Code

Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Malligarjunan Rajavel, Vijay Kumar, Ha Nguyen, Jacob Wyatt, Steven H. Marshall, Krisztina M. Papp-Wallace, Prasad Deshpande, Satish Bhavsar, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel, Robert A. Bonomo, Focco van den Akker
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2021
Sujets:	Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/4aa59e08d52045aea5cd17d19b97f5ff
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Resistance to β-lactam antibiotics conferred by point mutations in penicillin-binding proteins PBP3, PBP4 and PBP6 in Salmonella enterica.
par: Song Sun, et autres
Publié: (2014)

The Penicillin-Binding Protein PbpP Is a Sensor of β-Lactams and Is Required for Activation of the Extracytoplasmic Function σ Factor σ <sup>P</sup> in Bacillus thuringiensis
par: Kelsie M. Nauta, et autres
Publié: (2021)

Sub-inhibitory cefsulodin sensitization of E. coli to β-lactams is mediated by PBP1b inhibition.
par: Sujoy K Sarkar, et autres
Publié: (2012)

Targeting of PBP1 by β-lactams determines recA/SOS response activation in heterogeneous MRSA clinical strains.
par: Konrad B Plata, et autres
Publié: (2013)

Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in <named-content content-type="genus-species">Enterococcus faecalis</named-content>
par: Louis B. Rice, et autres
Publié: (2018)

Computer-aided design, synthesis, and characterization of molecular hybrids of dihydropyrazoles, aminopyrimidines, and thiazolidin-4-ones as potential inhibitors of the penicillin-binding protein 3 (PBP-3) of Escherichia coli
par: Fabián Orozco-López, Liliana Rocío Guerrero Villalobos , Paola Andrea Cuervo Prado
Publié: (2021)

Characterization of <i>Haemophilus influenzae</i> Strains with Non-Enzymatic Resistance to β-Lactam Antibiotics Caused by Mutations in the PBP3 Gene in the Czech Republic in 2010–2018
par: Vladislav Jakubu, et autres
Publié: (2021)

Identification of Mutations in the <italic toggle="yes">mrdA</italic> Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of <named-content content-type="genus-species">Escherichia coli</named-content> Clinical Isolates with Mutations in <italic toggle="yes">ftsI</italic> (PBP3) and Which Carry <italic toggle="yes">bla</italic><sub>NDM-1</sub>
par: Srijan Ranjitkar, et autres
Publié: (2019)

<i>Staphylococcus pseudintermedius</i>’s PBP4 Is Directly Associated with the Dissociated Oxacillin and Cefoxitin Phenotype
par: Paula Gagetti, et autres
Publié: (2021)

Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex
par: Carlos Contreras-Martel, et autres
Publié: (2017)

CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution
par: Nathanael A. Caveney, et autres
Publié: (2021)

Immunofluorescence Targeting PBP2a Protein: A New Potential Methicillin Resistance Screening Test
par: Serenella Silvestri, et autres
Publié: (2021)

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.
par: Vijay Kumar, et autres
Publié: (2021)

Pbp1, the yeast ortholog of human Ataxin-2, functions in the cell growth on non-fermentable carbon sources.
par: Dang Thi Tuong Vi, et autres
Publié: (2021)

Functional characterization of PBP1 gene in Helicoverpa armigera (Lepidoptera: Noctuidae) by using the CRISPR/Cas9 system
par: Zhan-Feng Ye, et autres
Publié: (2017)

Discovery of a Diverse Set of Bacteria That Build Their Cell Walls without the Canonical Peptidoglycan Polymerase aPBP
par: Sharanjeet Atwal, et autres
Publié: (2021)

Rapid MRSA detection via tandem mass spectrometry of the intact 80 kDa PBP2a resistance protein
par: Jason R. Neil, et autres
Publié: (2021)

Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN
par: Adrien Boes, et autres
Publié: (2019)

Fluorescence anisotropy assays for high throughput screening of compounds binding to lipid II, PBP1b, FtsW and MurJ
par: Adrien Boes, et autres
Publié: (2020)

Molecular dynamics simulation of the complex PBP-2x with drug cefuroxime to explore the drug resistance mechanism of Streptococcus suis R61.
par: Yan Ge, et autres
Publié: (2012)

Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein.
par: Bartolomé Moya, et autres
Publié: (2009)

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 4: β‐Lactams: amoxicillin and penicillin V
par: EFSA Panel on Biological Hazards (BIOHAZ), et autres
Publié: (2021)

Multidrug-resistant Staphylococcus cohnii and Staphylococcus urealyticus isolates from German dairy farms exhibit resistance to beta-lactam antibiotics and divergent penicillin-binding proteins
par: Tobias Lienen, et autres
Publié: (2021)

Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
par: Yuan Li, et autres
Publié: (2016)

Insights into the antibacterial mechanism of PEGylated nano-bacitracin A against Streptococcus pneumonia: both penicillin-sensitive and penicillin-resistant strains
par: Hong W, et autres
Publié: (2018)

Insights into the antibacterial mechanism of PEGylated nano-bacitracin A against Streptococcus pneumonia: both penicillin-sensitive and penicillin-resistant strains [Corrigendum]
par: Hong W, et autres
Publié: (2019)

Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
par: Ali R. Awan, et autres
Publié: (2017)

Human metallo-β-lactamase enzymes degrade penicillin
par: Seydina M. Diene, et autres
Publié: (2019)

Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4.
par: Marcelo Hill, et autres
Publié: (2011)

High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease.
par: Ezra B Ketema, et autres
Publié: (2021)

Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles
par: Yariv I, et autres
Publié: (2015)

Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases
par: Fica,Alberto, et autres
Publié: (2020)

Reversible inactivation of a peptidoglycan transpeptidase by a β-lactam antibiotic mediated by β-lactam-ring recyclization in the enzyme active site
par: Zainab Edoo, et autres
Publié: (2017)

Amide nitrogen pyramidalization changes lactam amide spinning
par: Yuko Otani, et autres
Publié: (2019)

COMMENSAL STRAINS OF ESCHERICHIA COLI AND BETA-LACTAM RESISTANCE
par: L. V. Suzhaeva, et autres
Publié: (2018)

Targeting Multidrug-Resistant <italic toggle="yes">Acinetobacter</italic> spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent
par: Melissa D. Barnes, et autres
Publié: (2019)

Seven-Membered Lactam Derivatives of Podophyllotoxins as New Pesticidal Agents
par: Xiaoyan Zhi, et autres
Publié: (2017)

Cryo-Electron Microscopy Structure of an <named-content content-type="genus-species">Acinetobacter baumannii</named-content> Multidrug Efflux Pump
par: Chih-Chia Su, et autres
Publié: (2019)

The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
par: Han Feng, et autres
Publié: (2017)

Extraction of Penicillin V from Simulated Fermentation Broth by Liquid-Liquid Membrane Technique
par: Khalid W. Hameed
Publié: (2012)