Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.

Central mechanisms by which specific motor programs are selected to achieve meaningful behaviors are not well understood. Using electrophysiological recordings from pharyngeal nerves upon central activation of neurotransmitter-expressing cells, we show that distinct neuronal ensembles can regulate d...

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Autores principales:	Andreas Schoofs, Sebastian Hückesfeld, Philipp Schlegel, Anton Miroschnikow, Marc Peters, Malou Zeymer, Roland Spieß, Ann-Shyn Chiang, Michael J Pankratz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4aa881e0a9e94e1daedcaf13e910cee8
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spelling	oai:doaj.org-article:4aa881e0a9e94e1daedcaf13e910cee82021-11-11T05:37:07ZSelection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.1544-91731545-788510.1371/journal.pbio.1001893https://doaj.org/article/4aa881e0a9e94e1daedcaf13e910cee82014-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24960360/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Central mechanisms by which specific motor programs are selected to achieve meaningful behaviors are not well understood. Using electrophysiological recordings from pharyngeal nerves upon central activation of neurotransmitter-expressing cells, we show that distinct neuronal ensembles can regulate different feeding motor programs. In behavioral and electrophysiological experiments, activation of 20 neurons in the brain expressing the neuropeptide hugin, a homolog of mammalian neuromedin U, simultaneously suppressed the motor program for food intake while inducing the motor program for locomotion. Decreasing hugin neuropeptide levels in the neurons by RNAi prevented this action. Reducing the level of hugin neuronal activity alone did not have any effect on feeding or locomotion motor programs. Furthermore, use of promoter-specific constructs that labeled subsets of hugin neurons demonstrated that initiation of locomotion can be separated from modulation of its motor pattern. These results provide insights into a neural mechanism of how opposing motor programs can be selected in order to coordinate feeding and locomotive behaviors.Andreas SchoofsSebastian HückesfeldPhilipp SchlegelAnton MiroschnikowMarc PetersMalou ZeymerRoland SpießAnn-Shyn ChiangMichael J PankratzPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 12, Iss 6, p e1001893 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Andreas Schoofs Sebastian Hückesfeld Philipp Schlegel Anton Miroschnikow Marc Peters Malou Zeymer Roland Spieß Ann-Shyn Chiang Michael J Pankratz Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.
description	Central mechanisms by which specific motor programs are selected to achieve meaningful behaviors are not well understood. Using electrophysiological recordings from pharyngeal nerves upon central activation of neurotransmitter-expressing cells, we show that distinct neuronal ensembles can regulate different feeding motor programs. In behavioral and electrophysiological experiments, activation of 20 neurons in the brain expressing the neuropeptide hugin, a homolog of mammalian neuromedin U, simultaneously suppressed the motor program for food intake while inducing the motor program for locomotion. Decreasing hugin neuropeptide levels in the neurons by RNAi prevented this action. Reducing the level of hugin neuronal activity alone did not have any effect on feeding or locomotion motor programs. Furthermore, use of promoter-specific constructs that labeled subsets of hugin neurons demonstrated that initiation of locomotion can be separated from modulation of its motor pattern. These results provide insights into a neural mechanism of how opposing motor programs can be selected in order to coordinate feeding and locomotive behaviors.
format	article
author	Andreas Schoofs Sebastian Hückesfeld Philipp Schlegel Anton Miroschnikow Marc Peters Malou Zeymer Roland Spieß Ann-Shyn Chiang Michael J Pankratz
author_facet	Andreas Schoofs Sebastian Hückesfeld Philipp Schlegel Anton Miroschnikow Marc Peters Malou Zeymer Roland Spieß Ann-Shyn Chiang Michael J Pankratz
author_sort	Andreas Schoofs
title	Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.
title_short	Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.
title_full	Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.
title_fullStr	Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.
title_full_unstemmed	Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.
title_sort	selection of motor programs for suppressing food intake and inducing locomotion in the drosophila brain.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/4aa881e0a9e94e1daedcaf13e910cee8
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Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain.

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