Differential regulation of breast cancer bone metastasis by PARP1 and PARP2

The effect of PARP inhibitors on bone mass and bone metastasis are unclear. Here, the authors show that PARP1/2 dual inhibitors may increase cancer bone metastasis through PARP2-dependent regulation of immature myeloid cells, and cause bone loss through PARP1/2-dependent regulation of osteoclasts.

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Bibliographic Details
Main Authors:	Hao Zuo, Dengbao Yang, Qiwen Yang, Haidong Tang, Yang-Xin Fu, Yihong Wan
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/4ab0627a85d644db82a8b2b8a0f4f8d7
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spelling	oai:doaj.org-article:4ab0627a85d644db82a8b2b8a0f4f8d72021-12-02T14:41:23ZDifferential regulation of breast cancer bone metastasis by PARP1 and PARP210.1038/s41467-020-15429-z2041-1723https://doaj.org/article/4ab0627a85d644db82a8b2b8a0f4f8d72020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15429-zhttps://doaj.org/toc/2041-1723The effect of PARP inhibitors on bone mass and bone metastasis are unclear. Here, the authors show that PARP1/2 dual inhibitors may increase cancer bone metastasis through PARP2-dependent regulation of immature myeloid cells, and cause bone loss through PARP1/2-dependent regulation of osteoclasts.Hao ZuoDengbao YangQiwen YangHaidong TangYang-Xin FuYihong WanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Zuo Dengbao Yang Qiwen Yang Haidong Tang Yang-Xin Fu Yihong Wan Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
description	The effect of PARP inhibitors on bone mass and bone metastasis are unclear. Here, the authors show that PARP1/2 dual inhibitors may increase cancer bone metastasis through PARP2-dependent regulation of immature myeloid cells, and cause bone loss through PARP1/2-dependent regulation of osteoclasts.
format	article
author	Hao Zuo Dengbao Yang Qiwen Yang Haidong Tang Yang-Xin Fu Yihong Wan
author_facet	Hao Zuo Dengbao Yang Qiwen Yang Haidong Tang Yang-Xin Fu Yihong Wan
author_sort	Hao Zuo
title	Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
title_short	Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
title_full	Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
title_fullStr	Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
title_full_unstemmed	Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
title_sort	differential regulation of breast cancer bone metastasis by parp1 and parp2
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4ab0627a85d644db82a8b2b8a0f4f8d7
work_keys_str_mv	AT haozuo differentialregulationofbreastcancerbonemetastasisbyparp1andparp2 AT dengbaoyang differentialregulationofbreastcancerbonemetastasisbyparp1andparp2 AT qiwenyang differentialregulationofbreastcancerbonemetastasisbyparp1andparp2 AT haidongtang differentialregulationofbreastcancerbonemetastasisbyparp1andparp2 AT yangxinfu differentialregulationofbreastcancerbonemetastasisbyparp1andparp2 AT yihongwan differentialregulationofbreastcancerbonemetastasisbyparp1andparp2
_version_	1718389868172673024

Differential regulation of breast cancer bone metastasis by PARP1 and PARP2

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