A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings

Derivatization of natural products is a powerful approach to generate new molecules for biological screenings. Here, the authors employ C-H oxidation and ring expansion methods for the preparation of a library of medium-sized ring skeleta, which occupy a unique chemical space based on chemoinformati...

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Autores principales:	Changgui Zhao, Zhengqing Ye, Zhi-xiong Ma, Scott A. Wildman, Stephanie A. Blaszczyk, Lihong Hu, Ilia A. Guizei, Weiping Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ab602c348e54d1a893e9ad00536ae7a
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spelling	oai:doaj.org-article:4ab602c348e54d1a893e9ad00536ae7a2021-12-02T15:35:17ZA general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings10.1038/s41467-019-11976-22041-1723https://doaj.org/article/4ab602c348e54d1a893e9ad00536ae7a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11976-2https://doaj.org/toc/2041-1723Derivatization of natural products is a powerful approach to generate new molecules for biological screenings. Here, the authors employ C-H oxidation and ring expansion methods for the preparation of a library of medium-sized ring skeleta, which occupy a unique chemical space based on chemoinformatic analysis.Changgui ZhaoZhengqing YeZhi-xiong MaScott A. WildmanStephanie A. BlaszczykLihong HuIlia A. GuizeiWeiping TangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changgui Zhao Zhengqing Ye Zhi-xiong Ma Scott A. Wildman Stephanie A. Blaszczyk Lihong Hu Ilia A. Guizei Weiping Tang A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
description	Derivatization of natural products is a powerful approach to generate new molecules for biological screenings. Here, the authors employ C-H oxidation and ring expansion methods for the preparation of a library of medium-sized ring skeleta, which occupy a unique chemical space based on chemoinformatic analysis.
format	article
author	Changgui Zhao Zhengqing Ye Zhi-xiong Ma Scott A. Wildman Stephanie A. Blaszczyk Lihong Hu Ilia A. Guizei Weiping Tang
author_facet	Changgui Zhao Zhengqing Ye Zhi-xiong Ma Scott A. Wildman Stephanie A. Blaszczyk Lihong Hu Ilia A. Guizei Weiping Tang
author_sort	Changgui Zhao
title	A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
title_short	A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
title_full	A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
title_fullStr	A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
title_full_unstemmed	A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
title_sort	general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4ab602c348e54d1a893e9ad00536ae7a
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A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings

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