Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients

Adoptive cell therapy (ACT) using neoantigen-specific T cells can lead to tumor regression. Here the authors use an in vitro stimulation approach to isolate tumor specific memory T cells from peripheral blood of metastatic epithelial cancer patients targeting unique as well as shared mutations in th...

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Autores principales:	Gal Cafri, Rami Yossef, Anna Pasetto, Drew C. Deniger, Yong-Chen Lu, Maria Parkhurst, Jared J. Gartner, Li Jia, Satyajit Ray, Lien T. Ngo, Mohammad Jafferji, Abraham Sachs, Todd Prickett, Paul F. Robbins, Steven A. Rosenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4abe5b00b67f409c95fdd11f690fc2b9
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spelling	oai:doaj.org-article:4abe5b00b67f409c95fdd11f690fc2b92021-12-02T14:38:41ZMemory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients10.1038/s41467-019-08304-z2041-1723https://doaj.org/article/4abe5b00b67f409c95fdd11f690fc2b92019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08304-zhttps://doaj.org/toc/2041-1723Adoptive cell therapy (ACT) using neoantigen-specific T cells can lead to tumor regression. Here the authors use an in vitro stimulation approach to isolate tumor specific memory T cells from peripheral blood of metastatic epithelial cancer patients targeting unique as well as shared mutations in the KRAS oncogene.Gal CafriRami YossefAnna PasettoDrew C. DenigerYong-Chen LuMaria ParkhurstJared J. GartnerLi JiaSatyajit RayLien T. NgoMohammad JafferjiAbraham SachsTodd PrickettPaul F. RobbinsSteven A. RosenbergNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gal Cafri Rami Yossef Anna Pasetto Drew C. Deniger Yong-Chen Lu Maria Parkhurst Jared J. Gartner Li Jia Satyajit Ray Lien T. Ngo Mohammad Jafferji Abraham Sachs Todd Prickett Paul F. Robbins Steven A. Rosenberg Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
description	Adoptive cell therapy (ACT) using neoantigen-specific T cells can lead to tumor regression. Here the authors use an in vitro stimulation approach to isolate tumor specific memory T cells from peripheral blood of metastatic epithelial cancer patients targeting unique as well as shared mutations in the KRAS oncogene.
format	article
author	Gal Cafri Rami Yossef Anna Pasetto Drew C. Deniger Yong-Chen Lu Maria Parkhurst Jared J. Gartner Li Jia Satyajit Ray Lien T. Ngo Mohammad Jafferji Abraham Sachs Todd Prickett Paul F. Robbins Steven A. Rosenberg
author_facet	Gal Cafri Rami Yossef Anna Pasetto Drew C. Deniger Yong-Chen Lu Maria Parkhurst Jared J. Gartner Li Jia Satyajit Ray Lien T. Ngo Mohammad Jafferji Abraham Sachs Todd Prickett Paul F. Robbins Steven A. Rosenberg
author_sort	Gal Cafri
title	Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
title_short	Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
title_full	Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
title_fullStr	Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
title_full_unstemmed	Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
title_sort	memory t cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4abe5b00b67f409c95fdd11f690fc2b9
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Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients

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