Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19
Although, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) represents one of the biggest challenges in the world today, the exact immunopathogenic mechanism that leads to severe or critical Coronavirus Disease 2019 (COVID-19) has remained incompletely understood. Several studies have ind...
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MDPI AG
2021
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oai:doaj.org-article:4abf56841db94e2d86229b6153d4b3ae2021-11-25T16:47:48ZClinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-1910.3390/biology101111862079-7737https://doaj.org/article/4abf56841db94e2d86229b6153d4b3ae2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1186https://doaj.org/toc/2079-7737Although, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) represents one of the biggest challenges in the world today, the exact immunopathogenic mechanism that leads to severe or critical Coronavirus Disease 2019 (COVID-19) has remained incompletely understood. Several studies have indicated that high systemic plasma levels of inflammatory cytokines result in the so-called “cytokine storm”, with subsequent development of microthrombosis, disseminated intravascular coagulation, and multiorgan-failure. Therefore, we reasoned those elevated inflammatory molecules might act as prognostic factors. Here, we analyzed 245 serum samples of patients with COVID-19, collected at hospital admission. We assessed the levels of heat shock protein 27 (HSP27), soluble suppressor of tumorigenicity-2 (sST2) and 20S proteasome at hospital admission and explored their associations with overall-, 30-, 60-, 90-day- and in-hospital mortality. Moreover, we investigated their association with the risk of ventilation. We demonstrated that increased serum sST2 was uni- and multivariably associated with all endpoints. Furthermore, we also identified 20S proteasome as independent prognostic factor for in-hospital mortality (sST2, AUC = 0.73; HSP27, AUC = 0.59; 20S proteasome = 0.67). Elevated sST2, HSP27, and 20S proteasome levels at hospital admission were univariably associated with higher risk of invasive ventilation (OR = 1.8; <i>p</i> < 0.001; OR = 1.1; <i>p</i> = 0.04; OR = 1.03, <i>p</i> = 0.03, respectively). These findings could help to identify high-risk patients early in the course of COVID-19.Ralph WendtMarie-Therese LingitzMaria LaggnerMichael MildnerDenise TraxlerAlexandra GrafPavla KrotkaBernhard MoserKonrad HoetzeneckerSven KalbitzChristoph LübbertJoachim BeigeHendrik Jan AnkersmitMDPI AGarticleCOVID-19HSP27sST2ARDSbiomarker20S proteasomeBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1186, p 1186 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
COVID-19 HSP27 sST2 ARDS biomarker 20S proteasome Biology (General) QH301-705.5 |
| spellingShingle |
COVID-19 HSP27 sST2 ARDS biomarker 20S proteasome Biology (General) QH301-705.5 Ralph Wendt Marie-Therese Lingitz Maria Laggner Michael Mildner Denise Traxler Alexandra Graf Pavla Krotka Bernhard Moser Konrad Hoetzenecker Sven Kalbitz Christoph Lübbert Joachim Beige Hendrik Jan Ankersmit Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19 |
| description |
Although, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) represents one of the biggest challenges in the world today, the exact immunopathogenic mechanism that leads to severe or critical Coronavirus Disease 2019 (COVID-19) has remained incompletely understood. Several studies have indicated that high systemic plasma levels of inflammatory cytokines result in the so-called “cytokine storm”, with subsequent development of microthrombosis, disseminated intravascular coagulation, and multiorgan-failure. Therefore, we reasoned those elevated inflammatory molecules might act as prognostic factors. Here, we analyzed 245 serum samples of patients with COVID-19, collected at hospital admission. We assessed the levels of heat shock protein 27 (HSP27), soluble suppressor of tumorigenicity-2 (sST2) and 20S proteasome at hospital admission and explored their associations with overall-, 30-, 60-, 90-day- and in-hospital mortality. Moreover, we investigated their association with the risk of ventilation. We demonstrated that increased serum sST2 was uni- and multivariably associated with all endpoints. Furthermore, we also identified 20S proteasome as independent prognostic factor for in-hospital mortality (sST2, AUC = 0.73; HSP27, AUC = 0.59; 20S proteasome = 0.67). Elevated sST2, HSP27, and 20S proteasome levels at hospital admission were univariably associated with higher risk of invasive ventilation (OR = 1.8; <i>p</i> < 0.001; OR = 1.1; <i>p</i> = 0.04; OR = 1.03, <i>p</i> = 0.03, respectively). These findings could help to identify high-risk patients early in the course of COVID-19. |
| format |
article |
| author |
Ralph Wendt Marie-Therese Lingitz Maria Laggner Michael Mildner Denise Traxler Alexandra Graf Pavla Krotka Bernhard Moser Konrad Hoetzenecker Sven Kalbitz Christoph Lübbert Joachim Beige Hendrik Jan Ankersmit |
| author_facet |
Ralph Wendt Marie-Therese Lingitz Maria Laggner Michael Mildner Denise Traxler Alexandra Graf Pavla Krotka Bernhard Moser Konrad Hoetzenecker Sven Kalbitz Christoph Lübbert Joachim Beige Hendrik Jan Ankersmit |
| author_sort |
Ralph Wendt |
| title |
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19 |
| title_short |
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19 |
| title_full |
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19 |
| title_fullStr |
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19 |
| title_full_unstemmed |
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19 |
| title_sort |
clinical relevance of elevated soluble st2, hsp27 and 20s proteasome at hospital admission in patients with covid-19 |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/4abf56841db94e2d86229b6153d4b3ae |
| work_keys_str_mv |
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