A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells

Renal tumour-initiating cells (T-ICs) contribute to tumour initiation and progression. Here, the authors show that lncARSR regulates TICs by blocking LATS1-induced YAP phosphorylation facilitating YAP nuclear translocation, which promotes lncARSR transcription, thus forming a feed-forward circuit to...

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Autores principales:	Le Qu, Zhenjie Wu, Yaoming Li, Zhipeng Xu, Bing Liu, Feng Liu, Yi Bao, Dengshuang Wu, Jiayi Liu, Anbang Wang, Xiaoyuan Chu, Yinghao Sun, Cheng Chen, Zhengyu Zhang, Linhui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ac076f70f734f76a9fc96f7581f1345
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spelling	oai:doaj.org-article:4ac076f70f734f76a9fc96f7581f13452021-12-02T14:40:12ZA feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells10.1038/ncomms126922041-1723https://doaj.org/article/4ac076f70f734f76a9fc96f7581f13452016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms12692https://doaj.org/toc/2041-1723Renal tumour-initiating cells (T-ICs) contribute to tumour initiation and progression. Here, the authors show that lncARSR regulates TICs by blocking LATS1-induced YAP phosphorylation facilitating YAP nuclear translocation, which promotes lncARSR transcription, thus forming a feed-forward circuit to promote TIC expansion.Le QuZhenjie WuYaoming LiZhipeng XuBing LiuFeng LiuYi BaoDengshuang WuJiayi LiuAnbang WangXiaoyuan ChuYinghao SunCheng ChenZhengyu ZhangLinhui WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Le Qu Zhenjie Wu Yaoming Li Zhipeng Xu Bing Liu Feng Liu Yi Bao Dengshuang Wu Jiayi Liu Anbang Wang Xiaoyuan Chu Yinghao Sun Cheng Chen Zhengyu Zhang Linhui Wang A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells
description	Renal tumour-initiating cells (T-ICs) contribute to tumour initiation and progression. Here, the authors show that lncARSR regulates TICs by blocking LATS1-induced YAP phosphorylation facilitating YAP nuclear translocation, which promotes lncARSR transcription, thus forming a feed-forward circuit to promote TIC expansion.
format	article
author	Le Qu Zhenjie Wu Yaoming Li Zhipeng Xu Bing Liu Feng Liu Yi Bao Dengshuang Wu Jiayi Liu Anbang Wang Xiaoyuan Chu Yinghao Sun Cheng Chen Zhengyu Zhang Linhui Wang
author_facet	Le Qu Zhenjie Wu Yaoming Li Zhipeng Xu Bing Liu Feng Liu Yi Bao Dengshuang Wu Jiayi Liu Anbang Wang Xiaoyuan Chu Yinghao Sun Cheng Chen Zhengyu Zhang Linhui Wang
author_sort	Le Qu
title	A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells
title_short	A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells
title_full	A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells
title_fullStr	A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells
title_full_unstemmed	A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells
title_sort	feed-forward loop between lncarsr and yap activity promotes expansion of renal tumour-initiating cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4ac076f70f734f76a9fc96f7581f1345
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A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells

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