Oxidative stress and radioiodine treatment of differentiated thyroid cancer

Abstract It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement...

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Autores principales:	Angelika Buczyńska, Iwona Sidorkiewicz, Mariusz Rogucki, Katarzyna Siewko, Agnieszka Adamska, Maria Kościuszko, Katarzyna Maliszewska, Gabryela Kozłowska, Piotr Szumowski, Janusz Myśliwiec, Janusz Dzięcioł, Adam Krętowski, Anna Popławska-Kita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ac294573b214a85bfc638efd57224b9
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spelling	oai:doaj.org-article:4ac294573b214a85bfc638efd57224b92021-12-02T19:02:23ZOxidative stress and radioiodine treatment of differentiated thyroid cancer10.1038/s41598-021-96637-52045-2322https://doaj.org/article/4ac294573b214a85bfc638efd57224b92021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96637-5https://doaj.org/toc/2045-2322Abstract It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malondialdehyde (MDA) concentration in patients with differentiated thyroid cancer (DTC) undergoing RAI treatment. Considering the results obtained in the study group, the serum levels of MDA in DTC patients were significantly higher compared to the healthy subjects (p < 0.05). The MDA concentration was significantly higher on the third day after RAI (p < 0.001) and significantly lower one year after RAI (p < 0.05) in DTC patients compared to the baseline concentration. Moreover, the redox stabilization after RAI treatment in patients with DTC during a year-long observation was demonstrated. Accordingly, an increased oxidative stress impact on the related biochemical parameters reflecting the health conditions of the DTC patients was determined. Our study showed that increased oxidative stress reflected by MDA measurements in DTC patients is further enhanced by RAI, but this effect is no longer observed one year after the therapy.Angelika BuczyńskaIwona SidorkiewiczMariusz RoguckiKatarzyna SiewkoAgnieszka AdamskaMaria KościuszkoKatarzyna MaliszewskaGabryela KozłowskaPiotr SzumowskiJanusz MyśliwiecJanusz DzięciołAdam KrętowskiAnna Popławska-KitaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angelika Buczyńska Iwona Sidorkiewicz Mariusz Rogucki Katarzyna Siewko Agnieszka Adamska Maria Kościuszko Katarzyna Maliszewska Gabryela Kozłowska Piotr Szumowski Janusz Myśliwiec Janusz Dzięcioł Adam Krętowski Anna Popławska-Kita Oxidative stress and radioiodine treatment of differentiated thyroid cancer
description	Abstract It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malondialdehyde (MDA) concentration in patients with differentiated thyroid cancer (DTC) undergoing RAI treatment. Considering the results obtained in the study group, the serum levels of MDA in DTC patients were significantly higher compared to the healthy subjects (p < 0.05). The MDA concentration was significantly higher on the third day after RAI (p < 0.001) and significantly lower one year after RAI (p < 0.05) in DTC patients compared to the baseline concentration. Moreover, the redox stabilization after RAI treatment in patients with DTC during a year-long observation was demonstrated. Accordingly, an increased oxidative stress impact on the related biochemical parameters reflecting the health conditions of the DTC patients was determined. Our study showed that increased oxidative stress reflected by MDA measurements in DTC patients is further enhanced by RAI, but this effect is no longer observed one year after the therapy.
format	article
author	Angelika Buczyńska Iwona Sidorkiewicz Mariusz Rogucki Katarzyna Siewko Agnieszka Adamska Maria Kościuszko Katarzyna Maliszewska Gabryela Kozłowska Piotr Szumowski Janusz Myśliwiec Janusz Dzięcioł Adam Krętowski Anna Popławska-Kita
author_facet	Angelika Buczyńska Iwona Sidorkiewicz Mariusz Rogucki Katarzyna Siewko Agnieszka Adamska Maria Kościuszko Katarzyna Maliszewska Gabryela Kozłowska Piotr Szumowski Janusz Myśliwiec Janusz Dzięcioł Adam Krętowski Anna Popławska-Kita
author_sort	Angelika Buczyńska
title	Oxidative stress and radioiodine treatment of differentiated thyroid cancer
title_short	Oxidative stress and radioiodine treatment of differentiated thyroid cancer
title_full	Oxidative stress and radioiodine treatment of differentiated thyroid cancer
title_fullStr	Oxidative stress and radioiodine treatment of differentiated thyroid cancer
title_full_unstemmed	Oxidative stress and radioiodine treatment of differentiated thyroid cancer
title_sort	oxidative stress and radioiodine treatment of differentiated thyroid cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ac294573b214a85bfc638efd57224b9
work_keys_str_mv	AT angelikabuczynska oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT iwonasidorkiewicz oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT mariuszrogucki oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT katarzynasiewko oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT agnieszkaadamska oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT mariakosciuszko oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT katarzynamaliszewska oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT gabryelakozłowska oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT piotrszumowski oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT januszmysliwiec oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT januszdziecioł oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT adamkretowski oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer AT annapopławskakita oxidativestressandradioiodinetreatmentofdifferentiatedthyroidcancer
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Oxidative stress and radioiodine treatment of differentiated thyroid cancer

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