Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization
Inhibition in spinal nociceptive pathways is weaker and more labile in lamina I —where thermal input is primarily processed— than in lamina II that encodes predominantly high threshold mechanical input. This explains why noxious thermal input makes spinal circuits prone to catastrophic sensitization...
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Nature Portfolio
2020
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oai:doaj.org-article:4ac2ed6526874748a22aff64150835ea2021-12-02T17:06:35ZDifferential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization10.1038/s41467-020-17824-y2041-1723https://doaj.org/article/4ac2ed6526874748a22aff64150835ea2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17824-yhttps://doaj.org/toc/2041-1723Inhibition in spinal nociceptive pathways is weaker and more labile in lamina I —where thermal input is primarily processed— than in lamina II that encodes predominantly high threshold mechanical input. This explains why noxious thermal input makes spinal circuits prone to catastrophic sensitization.Francesco FerriniJimena Perez-SanchezSamuel FerlandLouis-Etienne LorenzoAntoine G. GodinIsabel Plasencia-FernandezMartin CottetAnnie CastonguayFeng WangChiara SalioNicolas DoyonAdalberto MerighiYves De KoninckNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Francesco Ferrini Jimena Perez-Sanchez Samuel Ferland Louis-Etienne Lorenzo Antoine G. Godin Isabel Plasencia-Fernandez Martin Cottet Annie Castonguay Feng Wang Chiara Salio Nicolas Doyon Adalberto Merighi Yves De Koninck Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization |
| description |
Inhibition in spinal nociceptive pathways is weaker and more labile in lamina I —where thermal input is primarily processed— than in lamina II that encodes predominantly high threshold mechanical input. This explains why noxious thermal input makes spinal circuits prone to catastrophic sensitization. |
| format |
article |
| author |
Francesco Ferrini Jimena Perez-Sanchez Samuel Ferland Louis-Etienne Lorenzo Antoine G. Godin Isabel Plasencia-Fernandez Martin Cottet Annie Castonguay Feng Wang Chiara Salio Nicolas Doyon Adalberto Merighi Yves De Koninck |
| author_facet |
Francesco Ferrini Jimena Perez-Sanchez Samuel Ferland Louis-Etienne Lorenzo Antoine G. Godin Isabel Plasencia-Fernandez Martin Cottet Annie Castonguay Feng Wang Chiara Salio Nicolas Doyon Adalberto Merighi Yves De Koninck |
| author_sort |
Francesco Ferrini |
| title |
Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization |
| title_short |
Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization |
| title_full |
Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization |
| title_fullStr |
Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization |
| title_full_unstemmed |
Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization |
| title_sort |
differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4ac2ed6526874748a22aff64150835ea |
| work_keys_str_mv |
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1718381548621791232 |