ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD51/PCNA regulation.

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Autores principales:	Su Hyung Park, Nalae Kang, Eunho Song, Minwoo Wie, Eun A. Lee, Sunyoung Hwang, Deokjae Lee, Jae Sun Ra, In Bae Park, Jieun Park, Sukhyun Kang, Jun Hong Park, Sungchul Hohng, Kyoo-young Lee, Kyungjae Myung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ac4913c149c4dd78292e37f24a832b8
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spelling	oai:doaj.org-article:4ac4913c149c4dd78292e37f24a832b82021-12-02T15:36:06ZATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress10.1038/s41467-019-13667-42041-1723https://doaj.org/article/4ac4913c149c4dd78292e37f24a832b82019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13667-4https://doaj.org/toc/2041-1723How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD51/PCNA regulation.Su Hyung ParkNalae KangEunho SongMinwoo WieEun A. LeeSunyoung HwangDeokjae LeeJae Sun RaIn Bae ParkJieun ParkSukhyun KangJun Hong ParkSungchul HohngKyoo-young LeeKyungjae MyungNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Su Hyung Park Nalae Kang Eunho Song Minwoo Wie Eun A. Lee Sunyoung Hwang Deokjae Lee Jae Sun Ra In Bae Park Jieun Park Sukhyun Kang Jun Hong Park Sungchul Hohng Kyoo-young Lee Kyungjae Myung ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
description	How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD51/PCNA regulation.
format	article
author	Su Hyung Park Nalae Kang Eunho Song Minwoo Wie Eun A. Lee Sunyoung Hwang Deokjae Lee Jae Sun Ra In Bae Park Jieun Park Sukhyun Kang Jun Hong Park Sungchul Hohng Kyoo-young Lee Kyungjae Myung
author_facet	Su Hyung Park Nalae Kang Eunho Song Minwoo Wie Eun A. Lee Sunyoung Hwang Deokjae Lee Jae Sun Ra In Bae Park Jieun Park Sukhyun Kang Jun Hong Park Sungchul Hohng Kyoo-young Lee Kyungjae Myung
author_sort	Su Hyung Park
title	ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
title_short	ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
title_full	ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
title_fullStr	ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
title_full_unstemmed	ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
title_sort	atad5 promotes replication restart by regulating rad51 and pcna in response to replication stress
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4ac4913c149c4dd78292e37f24a832b8
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ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

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