Predictors of transcatheter closure cancellation in children with ventricular septal defect

Background Ventricle septal defect (VSD) is the most common type of congenital heart disease in children. If definitive therapy delayed, failure to thrive and developmental delays can lead to decreased quality of life. The options for VSD closure include surgical and minimally invasive procedures wi...

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Autores principales:	Artha Christin Yulianti, Indah Kartika Murni, Noormanto Noormanto, Sasmito Nugroho
Formato:	article
Lenguaje:	EN
Publicado:	Indonesian Pediatric Society Publishing House 2021
Materias:	ventricular septal defect; transcatheterization closure; procedure cancellation; children Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/4acd2c77ca15454cbe293ab1301aa517
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spelling	oai:doaj.org-article:4acd2c77ca15454cbe293ab1301aa5172021-11-29T02:29:22ZPredictors of transcatheter closure cancellation in children with ventricular septal defect0030-93112338-476X10.14238/pi61.6.2021.311-6https://doaj.org/article/4acd2c77ca15454cbe293ab1301aa5172021-11-01T00:00:00Zhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2588https://doaj.org/toc/0030-9311https://doaj.org/toc/2338-476XBackground Ventricle septal defect (VSD) is the most common type of congenital heart disease in children. If definitive therapy delayed, failure to thrive and developmental delays can lead to decreased quality of life. The options for VSD closure include surgical and minimally invasive procedures with transcatheterization. Although transcatheterization is considered to be the safest therapy, the risk of complications can lead to cancellation of procedure. Objective To determine whether nutritional status, body height, VSD type and size, and type of device used were predictors of cancellation of transcatheter closure of VSD. Methods A retrospective cohort study using medical records was performed for all children who underwent transcatheter closure of VSD at Dr. Sardjito Hospital, Yogyakarta, Central Java, between January 2017 to March 2020. Cancellation of closure was defined as complications occurring during the procedure, such as cardiac conduction problems, valve regurgitation, and device embolization. Multivariate logistic regression analysis was done to determine independent predictors of closure cancellation. Results One hundred thirty-four children were enrolled. Independent variables that were significant predictors were doubly committed subarterial (DCSA) VSD type (OR 5.98; 95%CI 1.52 to 23.61; P=0.045), moderate VSD size (OR 15.59; 95%CI 4.67 to 52.06; P=0.001), and types of devices used: symmetric (OR 27.06; 95%CI 2.75 to 266.17; P=0.001), asymmetric (OR 16.46; 95%CI 2.15 to 210.0; P=0.001), and coil (OR 21.26; 95%CI 2.15 to 210.0; P=0.001). Taller body height was a protective factor against cancellation of the procedure (OR 0.98; 95%CI 0.96 to 1.00; P=0.008). Conclusion Significant predictors of cancellation of transcatheter VSD closure are DCSA VSD, moderate VSD size, as well as coil, symmetric, and asymmetric devices, and increased body height.Artha Christin YuliantiIndah Kartika MurniNoormanto NoormantoSasmito NugrohoIndonesian Pediatric Society Publishing Housearticleventricular septal defect; transcatheterization closure; procedure cancellation; childrenMedicineRPediatricsRJ1-570ENPaediatrica Indonesiana, Vol 61, Iss 6, Pp 311-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ventricular septal defect; transcatheterization closure; procedure cancellation; children Medicine R Pediatrics RJ1-570
spellingShingle	ventricular septal defect; transcatheterization closure; procedure cancellation; children Medicine R Pediatrics RJ1-570 Artha Christin Yulianti Indah Kartika Murni Noormanto Noormanto Sasmito Nugroho Predictors of transcatheter closure cancellation in children with ventricular septal defect
description	Background Ventricle septal defect (VSD) is the most common type of congenital heart disease in children. If definitive therapy delayed, failure to thrive and developmental delays can lead to decreased quality of life. The options for VSD closure include surgical and minimally invasive procedures with transcatheterization. Although transcatheterization is considered to be the safest therapy, the risk of complications can lead to cancellation of procedure. Objective To determine whether nutritional status, body height, VSD type and size, and type of device used were predictors of cancellation of transcatheter closure of VSD. Methods A retrospective cohort study using medical records was performed for all children who underwent transcatheter closure of VSD at Dr. Sardjito Hospital, Yogyakarta, Central Java, between January 2017 to March 2020. Cancellation of closure was defined as complications occurring during the procedure, such as cardiac conduction problems, valve regurgitation, and device embolization. Multivariate logistic regression analysis was done to determine independent predictors of closure cancellation. Results One hundred thirty-four children were enrolled. Independent variables that were significant predictors were doubly committed subarterial (DCSA) VSD type (OR 5.98; 95%CI 1.52 to 23.61; P=0.045), moderate VSD size (OR 15.59; 95%CI 4.67 to 52.06; P=0.001), and types of devices used: symmetric (OR 27.06; 95%CI 2.75 to 266.17; P=0.001), asymmetric (OR 16.46; 95%CI 2.15 to 210.0; P=0.001), and coil (OR 21.26; 95%CI 2.15 to 210.0; P=0.001). Taller body height was a protective factor against cancellation of the procedure (OR 0.98; 95%CI 0.96 to 1.00; P=0.008). Conclusion Significant predictors of cancellation of transcatheter VSD closure are DCSA VSD, moderate VSD size, as well as coil, symmetric, and asymmetric devices, and increased body height.
format	article
author	Artha Christin Yulianti Indah Kartika Murni Noormanto Noormanto Sasmito Nugroho
author_facet	Artha Christin Yulianti Indah Kartika Murni Noormanto Noormanto Sasmito Nugroho
author_sort	Artha Christin Yulianti
title	Predictors of transcatheter closure cancellation in children with ventricular septal defect
title_short	Predictors of transcatheter closure cancellation in children with ventricular septal defect
title_full	Predictors of transcatheter closure cancellation in children with ventricular septal defect
title_fullStr	Predictors of transcatheter closure cancellation in children with ventricular septal defect
title_full_unstemmed	Predictors of transcatheter closure cancellation in children with ventricular septal defect
title_sort	predictors of transcatheter closure cancellation in children with ventricular septal defect
publisher	Indonesian Pediatric Society Publishing House
publishDate	2021
url	https://doaj.org/article/4acd2c77ca15454cbe293ab1301aa517
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Predictors of transcatheter closure cancellation in children with ventricular septal defect

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