Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease

Abstract Quantifying variation in the ability to fight infection among free-living hosts is challenging and often constrained to one or a few measures of immune activity. While such measures are typically taken to reflect host resistance, they can also be shaped by pathogen effects, for example, if...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daisy E. Gates, Molly Staley, Luc Tardy, Mathieu Giraudeau, Geoffrey E. Hill, Kevin J. McGraw, Camille Bonneaud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4acd99ab8a1f491aad188848dc670c18
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4acd99ab8a1f491aad188848dc670c18
record_format	dspace
spelling	oai:doaj.org-article:4acd99ab8a1f491aad188848dc670c182021-12-02T14:26:20ZLevels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease10.1038/s41598-021-87464-92045-2322https://doaj.org/article/4acd99ab8a1f491aad188848dc670c182021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87464-9https://doaj.org/toc/2045-2322Abstract Quantifying variation in the ability to fight infection among free-living hosts is challenging and often constrained to one or a few measures of immune activity. While such measures are typically taken to reflect host resistance, they can also be shaped by pathogen effects, for example, if more virulent strains trigger more robust immune responses. Here, we test the extent to which pathogen-specific antibody levels, a commonly used measure of immunocompetence, reflect variation in host resistance versus pathogen virulence, and whether these antibodies effectively clear infection. House finches (Haemorhous mexicanus) from resistant and susceptible populations were inoculated with > 50 isolates of their novel Mycoplasma gallisepticum pathogen collected over a 20-year period during which virulence increased. Serum antibody levels were higher in finches from resistant populations and increased with year of pathogen sampling. Higher antibody levels, however, did not subsequently give rise to greater reductions in pathogen load. Our results show that antibody responses can be shaped by levels of host resistance and pathogen virulence, and do not necessarily signal immune clearance ability. While the generality of this novel finding remains unclear, particularly outside of mycoplasmas, it cautions against using antibody levels as implicit proxies for immunocompetence and/or host resistance.Daisy E. GatesMolly StaleyLuc TardyMathieu GiraudeauGeoffrey E. HillKevin J. McGrawCamille BonneaudNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daisy E. Gates Molly Staley Luc Tardy Mathieu Giraudeau Geoffrey E. Hill Kevin J. McGraw Camille Bonneaud Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease
description	Abstract Quantifying variation in the ability to fight infection among free-living hosts is challenging and often constrained to one or a few measures of immune activity. While such measures are typically taken to reflect host resistance, they can also be shaped by pathogen effects, for example, if more virulent strains trigger more robust immune responses. Here, we test the extent to which pathogen-specific antibody levels, a commonly used measure of immunocompetence, reflect variation in host resistance versus pathogen virulence, and whether these antibodies effectively clear infection. House finches (Haemorhous mexicanus) from resistant and susceptible populations were inoculated with > 50 isolates of their novel Mycoplasma gallisepticum pathogen collected over a 20-year period during which virulence increased. Serum antibody levels were higher in finches from resistant populations and increased with year of pathogen sampling. Higher antibody levels, however, did not subsequently give rise to greater reductions in pathogen load. Our results show that antibody responses can be shaped by levels of host resistance and pathogen virulence, and do not necessarily signal immune clearance ability. While the generality of this novel finding remains unclear, particularly outside of mycoplasmas, it cautions against using antibody levels as implicit proxies for immunocompetence and/or host resistance.
format	article
author	Daisy E. Gates Molly Staley Luc Tardy Mathieu Giraudeau Geoffrey E. Hill Kevin J. McGraw Camille Bonneaud
author_facet	Daisy E. Gates Molly Staley Luc Tardy Mathieu Giraudeau Geoffrey E. Hill Kevin J. McGraw Camille Bonneaud
author_sort	Daisy E. Gates
title	Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease
title_short	Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease
title_full	Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease
title_fullStr	Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease
title_full_unstemmed	Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease
title_sort	levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4acd99ab8a1f491aad188848dc670c18
work_keys_str_mv	AT daisyegates levelsofpathogenvirulenceandhostresistancebothshapetheantibodyresponsetoanemergingbacterialdisease AT mollystaley levelsofpathogenvirulenceandhostresistancebothshapetheantibodyresponsetoanemergingbacterialdisease AT luctardy levelsofpathogenvirulenceandhostresistancebothshapetheantibodyresponsetoanemergingbacterialdisease AT mathieugiraudeau levelsofpathogenvirulenceandhostresistancebothshapetheantibodyresponsetoanemergingbacterialdisease AT geoffreyehill levelsofpathogenvirulenceandhostresistancebothshapetheantibodyresponsetoanemergingbacterialdisease AT kevinjmcgraw levelsofpathogenvirulenceandhostresistancebothshapetheantibodyresponsetoanemergingbacterialdisease AT camillebonneaud levelsofpathogenvirulenceandhostresistancebothshapetheantibodyresponsetoanemergingbacterialdisease
_version_	1718391365877891072

Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease

Ejemplares similares