The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.

<h4>Introduction</h4>One third of the world's population is estimated to be latently infected with Mycobacterium tuberculosis (LTBI). Surveys of LTBI are rarely performed in resource poor TB high endemic countries like Tanzania although low-income countries harbor the largest burden...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andreas V Jensen, Lotte Jensen, Daniel Faurholt-Jepsen, Martine G Aabye, George Praygod, Jeremiah Kidola, Maria Faurholt-Jepsen, John Changalucha, Nyagosya Range, Henrik Krarup, Henrik Friis, Aase B Andersen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4acf6a00a3214caabcced2c456f0efa5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4acf6a00a3214caabcced2c456f0efa5
record_format	dspace
spelling	oai:doaj.org-article:4acf6a00a3214caabcced2c456f0efa52021-11-18T07:45:06ZThe prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.1932-620310.1371/journal.pone.0064008https://doaj.org/article/4acf6a00a3214caabcced2c456f0efa52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23700446/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>One third of the world's population is estimated to be latently infected with Mycobacterium tuberculosis (LTBI). Surveys of LTBI are rarely performed in resource poor TB high endemic countries like Tanzania although low-income countries harbor the largest burden of the worlds LTBI. The primary objective was to estimate the prevalence of LTBI in household contacts of pulmonary TB cases and a group of apparently healthy neighborhood controls in an urban setting of such a country. Secondly we assessed potential impact of LTBI on inflammation by quantitating circulating levels of an acute phase reactant: alpha-1-acid glycoprotein (AGP) in neighborhood controls.<h4>Methods</h4>The study was nested within the framework of two nutrition studies among TB patients in Mwanza, Tanzania. Household contacts- and neighborhood controls were invited to participate. The study involved a questionnaire, BMI determination and blood samples to measure AGP, HIV testing and a Quantiferon Gold In tube (QFN-IT) test to detect signs of LTBI.<h4>Results</h4>245 household contacts and 192 neighborhood controls had available QFN-IT data. Among household contacts, the proportion of QFT-IT positive was 59% compared to 41% in the neighborhood controls (p = 0.001). In a linear regression model adjusted for sex, age, CD4 and HIV, a QFT-IT positive test was associated with a 10% higher level of alpha-1-acid glycoprotein(AGP) (10(B) 1.10, 95% CI 1.01; 1.20, p = 0.03), compared to individuals with a QFT-IT negative test.<h4>Conclusion</h4>LTBI is highly prevalent among apparently healthy urban Tanzanians even without known exposure to TB in the household. LTBI was found to be associated with elevated levels of AGP. The implications of this observation merit further studies.Andreas V JensenLotte JensenDaniel Faurholt-JepsenMartine G AabyeGeorge PraygodJeremiah KidolaMaria Faurholt-JepsenJohn ChangaluchaNyagosya RangeHenrik KrarupHenrik FriisAase B AndersenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64008 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andreas V Jensen Lotte Jensen Daniel Faurholt-Jepsen Martine G Aabye George Praygod Jeremiah Kidola Maria Faurholt-Jepsen John Changalucha Nyagosya Range Henrik Krarup Henrik Friis Aase B Andersen The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.
description	<h4>Introduction</h4>One third of the world's population is estimated to be latently infected with Mycobacterium tuberculosis (LTBI). Surveys of LTBI are rarely performed in resource poor TB high endemic countries like Tanzania although low-income countries harbor the largest burden of the worlds LTBI. The primary objective was to estimate the prevalence of LTBI in household contacts of pulmonary TB cases and a group of apparently healthy neighborhood controls in an urban setting of such a country. Secondly we assessed potential impact of LTBI on inflammation by quantitating circulating levels of an acute phase reactant: alpha-1-acid glycoprotein (AGP) in neighborhood controls.<h4>Methods</h4>The study was nested within the framework of two nutrition studies among TB patients in Mwanza, Tanzania. Household contacts- and neighborhood controls were invited to participate. The study involved a questionnaire, BMI determination and blood samples to measure AGP, HIV testing and a Quantiferon Gold In tube (QFN-IT) test to detect signs of LTBI.<h4>Results</h4>245 household contacts and 192 neighborhood controls had available QFN-IT data. Among household contacts, the proportion of QFT-IT positive was 59% compared to 41% in the neighborhood controls (p = 0.001). In a linear regression model adjusted for sex, age, CD4 and HIV, a QFT-IT positive test was associated with a 10% higher level of alpha-1-acid glycoprotein(AGP) (10(B) 1.10, 95% CI 1.01; 1.20, p = 0.03), compared to individuals with a QFT-IT negative test.<h4>Conclusion</h4>LTBI is highly prevalent among apparently healthy urban Tanzanians even without known exposure to TB in the household. LTBI was found to be associated with elevated levels of AGP. The implications of this observation merit further studies.
format	article
author	Andreas V Jensen Lotte Jensen Daniel Faurholt-Jepsen Martine G Aabye George Praygod Jeremiah Kidola Maria Faurholt-Jepsen John Changalucha Nyagosya Range Henrik Krarup Henrik Friis Aase B Andersen
author_facet	Andreas V Jensen Lotte Jensen Daniel Faurholt-Jepsen Martine G Aabye George Praygod Jeremiah Kidola Maria Faurholt-Jepsen John Changalucha Nyagosya Range Henrik Krarup Henrik Friis Aase B Andersen
author_sort	Andreas V Jensen
title	The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.
title_short	The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.
title_full	The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.
title_fullStr	The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.
title_full_unstemmed	The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.
title_sort	prevalence of latent mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in mwanza, tanzania.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4acf6a00a3214caabcced2c456f0efa5
work_keys_str_mv	AT andreasvjensen theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT lottejensen theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT danielfaurholtjepsen theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT martinegaabye theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT georgepraygod theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT jeremiahkidola theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT mariafaurholtjepsen theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT johnchangalucha theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT nyagosyarange theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT henrikkrarup theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT henrikfriis theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT aasebandersen theprevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT andreasvjensen prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT lottejensen prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT danielfaurholtjepsen prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT martinegaabye prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT georgepraygod prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT jeremiahkidola prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT mariafaurholtjepsen prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT johnchangalucha prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT nyagosyarange prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT henrikkrarup prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT henrikfriis prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania AT aasebandersen prevalenceoflatentmycobacteriumtuberculosisinfectionbasedonaninterferongreleaseassayacrosssectionalsurveyamongurbanadultsinmwanzatanzania
_version_	1718423033335513088

The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.

Ejemplares similares