Local adaptations of Mediterranean sheep and goats through an integrative approach
Abstract Small ruminants are suited to a wide variety of habitats and thus represent promising study models for identifying genes underlying adaptations. Here, we considered local Mediterranean breeds of goats (n = 17) and sheep (n = 25) from Italy, France and Spain. Based on historical archives, we...
Guardado en:
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/4acf838ec21746bdb2edf10cc7986526 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:4acf838ec21746bdb2edf10cc7986526 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:4acf838ec21746bdb2edf10cc79865262021-11-08T10:48:06ZLocal adaptations of Mediterranean sheep and goats through an integrative approach10.1038/s41598-021-00682-z2045-2322https://doaj.org/article/4acf838ec21746bdb2edf10cc79865262021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00682-zhttps://doaj.org/toc/2045-2322Abstract Small ruminants are suited to a wide variety of habitats and thus represent promising study models for identifying genes underlying adaptations. Here, we considered local Mediterranean breeds of goats (n = 17) and sheep (n = 25) from Italy, France and Spain. Based on historical archives, we selected the breeds potentially most linked to a territory and defined their original cradle (i.e., the geographical area in which the breed has emerged), including transhumant pastoral areas. We then used the programs PCAdapt and LFMM to identify signatures of artificial and environmental selection. Considering cradles instead of current GPS coordinates resulted in a greater number of signatures identified by the LFMM analysis. The results, combined with a systematic literature review, revealed a set of genes with potentially key adaptive roles in relation to the gradient of aridity and altitude. Some of these genes have been previously implicated in lipid metabolism (SUCLG2, BMP2), hypoxia stress/lung function (BMPR2), seasonal patterns (SOX2, DPH6) or neuronal function (TRPC4, TRPC6). Selection signatures involving the PCDH9 and KLH1 genes, as well as NBEA/NBEAL1, were identified in both species and thus could play an important adaptive role.Bruno SerranitoMarco CavalazziPablo VidalDominique Taurisson-MouretElena CianiMarie BalEric RouvellacBertrand ServinCarole Moreno-RomieuxGwenola Tosser-KloppStephen J. G. HallJohannes A. LenstraFrançois PompanonBadr BenjellounAnne Da SilvaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Bruno Serranito Marco Cavalazzi Pablo Vidal Dominique Taurisson-Mouret Elena Ciani Marie Bal Eric Rouvellac Bertrand Servin Carole Moreno-Romieux Gwenola Tosser-Klopp Stephen J. G. Hall Johannes A. Lenstra François Pompanon Badr Benjelloun Anne Da Silva Local adaptations of Mediterranean sheep and goats through an integrative approach |
description |
Abstract Small ruminants are suited to a wide variety of habitats and thus represent promising study models for identifying genes underlying adaptations. Here, we considered local Mediterranean breeds of goats (n = 17) and sheep (n = 25) from Italy, France and Spain. Based on historical archives, we selected the breeds potentially most linked to a territory and defined their original cradle (i.e., the geographical area in which the breed has emerged), including transhumant pastoral areas. We then used the programs PCAdapt and LFMM to identify signatures of artificial and environmental selection. Considering cradles instead of current GPS coordinates resulted in a greater number of signatures identified by the LFMM analysis. The results, combined with a systematic literature review, revealed a set of genes with potentially key adaptive roles in relation to the gradient of aridity and altitude. Some of these genes have been previously implicated in lipid metabolism (SUCLG2, BMP2), hypoxia stress/lung function (BMPR2), seasonal patterns (SOX2, DPH6) or neuronal function (TRPC4, TRPC6). Selection signatures involving the PCDH9 and KLH1 genes, as well as NBEA/NBEAL1, were identified in both species and thus could play an important adaptive role. |
format |
article |
author |
Bruno Serranito Marco Cavalazzi Pablo Vidal Dominique Taurisson-Mouret Elena Ciani Marie Bal Eric Rouvellac Bertrand Servin Carole Moreno-Romieux Gwenola Tosser-Klopp Stephen J. G. Hall Johannes A. Lenstra François Pompanon Badr Benjelloun Anne Da Silva |
author_facet |
Bruno Serranito Marco Cavalazzi Pablo Vidal Dominique Taurisson-Mouret Elena Ciani Marie Bal Eric Rouvellac Bertrand Servin Carole Moreno-Romieux Gwenola Tosser-Klopp Stephen J. G. Hall Johannes A. Lenstra François Pompanon Badr Benjelloun Anne Da Silva |
author_sort |
Bruno Serranito |
title |
Local adaptations of Mediterranean sheep and goats through an integrative approach |
title_short |
Local adaptations of Mediterranean sheep and goats through an integrative approach |
title_full |
Local adaptations of Mediterranean sheep and goats through an integrative approach |
title_fullStr |
Local adaptations of Mediterranean sheep and goats through an integrative approach |
title_full_unstemmed |
Local adaptations of Mediterranean sheep and goats through an integrative approach |
title_sort |
local adaptations of mediterranean sheep and goats through an integrative approach |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/4acf838ec21746bdb2edf10cc7986526 |
work_keys_str_mv |
AT brunoserranito localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT marcocavalazzi localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT pablovidal localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT dominiquetaurissonmouret localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT elenaciani localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT mariebal localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT ericrouvellac localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT bertrandservin localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT carolemorenoromieux localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT gwenolatosserklopp localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT stephenjghall localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT johannesalenstra localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT francoispompanon localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT badrbenjelloun localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach AT annedasilva localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach |
_version_ |
1718442614304276480 |