Local adaptations of Mediterranean sheep and goats through an integrative approach

Abstract Small ruminants are suited to a wide variety of habitats and thus represent promising study models for identifying genes underlying adaptations. Here, we considered local Mediterranean breeds of goats (n = 17) and sheep (n = 25) from Italy, France and Spain. Based on historical archives, we...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Bruno Serranito, Marco Cavalazzi, Pablo Vidal, Dominique Taurisson-Mouret, Elena Ciani, Marie Bal, Eric Rouvellac, Bertrand Servin, Carole Moreno-Romieux, Gwenola Tosser-Klopp, Stephen J. G. Hall, Johannes A. Lenstra, François Pompanon, Badr Benjelloun, Anne Da Silva
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/4acf838ec21746bdb2edf10cc7986526
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:4acf838ec21746bdb2edf10cc7986526
record_format dspace
spelling oai:doaj.org-article:4acf838ec21746bdb2edf10cc79865262021-11-08T10:48:06ZLocal adaptations of Mediterranean sheep and goats through an integrative approach10.1038/s41598-021-00682-z2045-2322https://doaj.org/article/4acf838ec21746bdb2edf10cc79865262021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00682-zhttps://doaj.org/toc/2045-2322Abstract Small ruminants are suited to a wide variety of habitats and thus represent promising study models for identifying genes underlying adaptations. Here, we considered local Mediterranean breeds of goats (n = 17) and sheep (n = 25) from Italy, France and Spain. Based on historical archives, we selected the breeds potentially most linked to a territory and defined their original cradle (i.e., the geographical area in which the breed has emerged), including transhumant pastoral areas. We then used the programs PCAdapt and LFMM to identify signatures of artificial and environmental selection. Considering cradles instead of current GPS coordinates resulted in a greater number of signatures identified by the LFMM analysis. The results, combined with a systematic literature review, revealed a set of genes with potentially key adaptive roles in relation to the gradient of aridity and altitude. Some of these genes have been previously implicated in lipid metabolism (SUCLG2, BMP2), hypoxia stress/lung function (BMPR2), seasonal patterns (SOX2, DPH6) or neuronal function (TRPC4, TRPC6). Selection signatures involving the PCDH9 and KLH1 genes, as well as NBEA/NBEAL1, were identified in both species and thus could play an important adaptive role.Bruno SerranitoMarco CavalazziPablo VidalDominique Taurisson-MouretElena CianiMarie BalEric RouvellacBertrand ServinCarole Moreno-RomieuxGwenola Tosser-KloppStephen J. G. HallJohannes A. LenstraFrançois PompanonBadr BenjellounAnne Da SilvaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Bruno Serranito
Marco Cavalazzi
Pablo Vidal
Dominique Taurisson-Mouret
Elena Ciani
Marie Bal
Eric Rouvellac
Bertrand Servin
Carole Moreno-Romieux
Gwenola Tosser-Klopp
Stephen J. G. Hall
Johannes A. Lenstra
François Pompanon
Badr Benjelloun
Anne Da Silva
Local adaptations of Mediterranean sheep and goats through an integrative approach
description Abstract Small ruminants are suited to a wide variety of habitats and thus represent promising study models for identifying genes underlying adaptations. Here, we considered local Mediterranean breeds of goats (n = 17) and sheep (n = 25) from Italy, France and Spain. Based on historical archives, we selected the breeds potentially most linked to a territory and defined their original cradle (i.e., the geographical area in which the breed has emerged), including transhumant pastoral areas. We then used the programs PCAdapt and LFMM to identify signatures of artificial and environmental selection. Considering cradles instead of current GPS coordinates resulted in a greater number of signatures identified by the LFMM analysis. The results, combined with a systematic literature review, revealed a set of genes with potentially key adaptive roles in relation to the gradient of aridity and altitude. Some of these genes have been previously implicated in lipid metabolism (SUCLG2, BMP2), hypoxia stress/lung function (BMPR2), seasonal patterns (SOX2, DPH6) or neuronal function (TRPC4, TRPC6). Selection signatures involving the PCDH9 and KLH1 genes, as well as NBEA/NBEAL1, were identified in both species and thus could play an important adaptive role.
format article
author Bruno Serranito
Marco Cavalazzi
Pablo Vidal
Dominique Taurisson-Mouret
Elena Ciani
Marie Bal
Eric Rouvellac
Bertrand Servin
Carole Moreno-Romieux
Gwenola Tosser-Klopp
Stephen J. G. Hall
Johannes A. Lenstra
François Pompanon
Badr Benjelloun
Anne Da Silva
author_facet Bruno Serranito
Marco Cavalazzi
Pablo Vidal
Dominique Taurisson-Mouret
Elena Ciani
Marie Bal
Eric Rouvellac
Bertrand Servin
Carole Moreno-Romieux
Gwenola Tosser-Klopp
Stephen J. G. Hall
Johannes A. Lenstra
François Pompanon
Badr Benjelloun
Anne Da Silva
author_sort Bruno Serranito
title Local adaptations of Mediterranean sheep and goats through an integrative approach
title_short Local adaptations of Mediterranean sheep and goats through an integrative approach
title_full Local adaptations of Mediterranean sheep and goats through an integrative approach
title_fullStr Local adaptations of Mediterranean sheep and goats through an integrative approach
title_full_unstemmed Local adaptations of Mediterranean sheep and goats through an integrative approach
title_sort local adaptations of mediterranean sheep and goats through an integrative approach
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4acf838ec21746bdb2edf10cc7986526
work_keys_str_mv AT brunoserranito localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT marcocavalazzi localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT pablovidal localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT dominiquetaurissonmouret localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT elenaciani localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT mariebal localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT ericrouvellac localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT bertrandservin localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT carolemorenoromieux localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT gwenolatosserklopp localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT stephenjghall localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT johannesalenstra localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT francoispompanon localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT badrbenjelloun localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
AT annedasilva localadaptationsofmediterraneansheepandgoatsthroughanintegrativeapproach
_version_ 1718442614304276480