In vivo characterization of ischemic retina in diabetic retinopathy

Lukas Reznicek, Marcus Kernt, Christos Haritoglou, Anselm Kampik, Michael Ulbig, Aljoscha S NeubauerDepartment of Ophthalmology, Ludwig Maximilian University, Munich, GermanyObjective: The aim of this article is to characterize pathomorphologic changes within particular layers of fluorescein angiogr...

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Autores principales:	Lukas Reznicek, Marcus Kernt, Christos Haritoglou, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4ad0be7212804c9181d6b6128d5deea2
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spelling	oai:doaj.org-article:4ad0be7212804c9181d6b6128d5deea22021-12-02T01:05:52ZIn vivo characterization of ischemic retina in diabetic retinopathy1177-54671177-5483https://doaj.org/article/4ad0be7212804c9181d6b6128d5deea22010-12-01T00:00:00Zhttp://www.dovepress.com/in-vivo-characterization-of-ischemic-retina-in-diabetic-retinopathy-a5983https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Lukas Reznicek, Marcus Kernt, Christos Haritoglou, Anselm Kampik, Michael Ulbig, Aljoscha S NeubauerDepartment of Ophthalmology, Ludwig Maximilian University, Munich, GermanyObjective: The aim of this article is to characterize pathomorphologic changes within particular layers of fluorescein angiographically &#39;ischemic&#39; compared to &#39;nonischemic&#39; retina in patients with diabetic retinopathy.Methods: Cross-sectional images of ischemic retinal areas were obtained using Heidelberg Spectralis optical coherence tomography (OCT). Presumed retinal ischemia was defined as focal hypofluorescence in early or early and late phase fluorescein angiography. Pathomorphologic changes on OCT were evaluated and the thickness of retinal layers measured and compared with nonischemic retina at corresponding topographic locations in a matched-pairs design based on 22 eyes (mean age 64 &plusmn; 14).Results: In all eyes, based on spectral domain-OCT cross-section images, the retina layers in ischemic retinal areas could be segmented. Total retinal thickness was significantly increased in ischemic compared to nonischemic areas (381 &plusmn; 94 &micro;m versus 323 &plusmn; 89 &micro;m, P = 0.005). Middle retinal layers (inner nuclear layer, outer plexiform layer, and outer nuclear layer) were significantly thickened in retinal ischemic areas (215 &plusmn; 82 &micro;m versus 168 &plusmn; 62 &micro;m, P = 0.002). The inner retinal layers (retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer) showed a nonsignificant change (117 &plusmn; 53 &micro;m versus 98 &plusmn; 30 &micro;m), while the outer layers were slightly thinned (photoreceptors plus retinal pigment epithelium layer; 51 &plusmn; 9 &micro;m versus 57 &plusmn; 8 &micro;m, P = 0.02) in ischemic versus nonischemic retina.Conclusions: Ischemic diabetic retina seems to be thickened due to thickening of, in particular, middle retinal layers, which can be measured with high-resolution OCT.Keywords: OCT, Spectralis OCT, fluorescein angiography, diabetic retinopathy, ischemic retina, retinal thickness, retinal layers Lukas ReznicekMarcus KerntChristos Haritoglouet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 31-35 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Lukas Reznicek Marcus Kernt Christos Haritoglou et al In vivo characterization of ischemic retina in diabetic retinopathy
description	Lukas Reznicek, Marcus Kernt, Christos Haritoglou, Anselm Kampik, Michael Ulbig, Aljoscha S NeubauerDepartment of Ophthalmology, Ludwig Maximilian University, Munich, GermanyObjective: The aim of this article is to characterize pathomorphologic changes within particular layers of fluorescein angiographically &#39;ischemic&#39; compared to &#39;nonischemic&#39; retina in patients with diabetic retinopathy.Methods: Cross-sectional images of ischemic retinal areas were obtained using Heidelberg Spectralis optical coherence tomography (OCT). Presumed retinal ischemia was defined as focal hypofluorescence in early or early and late phase fluorescein angiography. Pathomorphologic changes on OCT were evaluated and the thickness of retinal layers measured and compared with nonischemic retina at corresponding topographic locations in a matched-pairs design based on 22 eyes (mean age 64 &plusmn; 14).Results: In all eyes, based on spectral domain-OCT cross-section images, the retina layers in ischemic retinal areas could be segmented. Total retinal thickness was significantly increased in ischemic compared to nonischemic areas (381 &plusmn; 94 &micro;m versus 323 &plusmn; 89 &micro;m, P = 0.005). Middle retinal layers (inner nuclear layer, outer plexiform layer, and outer nuclear layer) were significantly thickened in retinal ischemic areas (215 &plusmn; 82 &micro;m versus 168 &plusmn; 62 &micro;m, P = 0.002). The inner retinal layers (retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer) showed a nonsignificant change (117 &plusmn; 53 &micro;m versus 98 &plusmn; 30 &micro;m), while the outer layers were slightly thinned (photoreceptors plus retinal pigment epithelium layer; 51 &plusmn; 9 &micro;m versus 57 &plusmn; 8 &micro;m, P = 0.02) in ischemic versus nonischemic retina.Conclusions: Ischemic diabetic retina seems to be thickened due to thickening of, in particular, middle retinal layers, which can be measured with high-resolution OCT.Keywords: OCT, Spectralis OCT, fluorescein angiography, diabetic retinopathy, ischemic retina, retinal thickness, retinal layers
format	article
author	Lukas Reznicek Marcus Kernt Christos Haritoglou et al
author_facet	Lukas Reznicek Marcus Kernt Christos Haritoglou et al
author_sort	Lukas Reznicek
title	In vivo characterization of ischemic retina in diabetic retinopathy
title_short	In vivo characterization of ischemic retina in diabetic retinopathy
title_full	In vivo characterization of ischemic retina in diabetic retinopathy
title_fullStr	In vivo characterization of ischemic retina in diabetic retinopathy
title_full_unstemmed	In vivo characterization of ischemic retina in diabetic retinopathy
title_sort	in vivo characterization of ischemic retina in diabetic retinopathy
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/4ad0be7212804c9181d6b6128d5deea2
work_keys_str_mv	AT lukasreznicek invivocharacterizationofischemicretinaindiabeticretinopathy AT marcuskernt invivocharacterizationofischemicretinaindiabeticretinopathy AT christosharitoglou invivocharacterizationofischemicretinaindiabeticretinopathy AT etal invivocharacterizationofischemicretinaindiabeticretinopathy
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In vivo characterization of ischemic retina in diabetic retinopathy

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