Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

Molenaar et al. use scRNA-seq to profile cardiac cell gene expression changes at three time points following ischemic injury. They observe that B2M is secreted by cardiomyocytes following injury, promoting scar formation. This data may be useful in finding therapeutic targets for cardiac repair

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Autores principales:	Bas Molenaar, Louk T. Timmer, Marjolein Droog, Ilaria Perini, Danielle Versteeg, Lieneke Kooijman, Jantine Monshouwer-Kloots, Hesther de Ruiter, Monika M. Gladka, Eva van Rooij
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4ad3dd3f14f6498bac1a498a6c119c9c
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spelling	oai:doaj.org-article:4ad3dd3f14f6498bac1a498a6c119c9c2021-12-02T13:57:36ZSingle-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair10.1038/s42003-020-01636-32399-3642https://doaj.org/article/4ad3dd3f14f6498bac1a498a6c119c9c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01636-3https://doaj.org/toc/2399-3642Molenaar et al. use scRNA-seq to profile cardiac cell gene expression changes at three time points following ischemic injury. They observe that B2M is secreted by cardiomyocytes following injury, promoting scar formation. This data may be useful in finding therapeutic targets for cardiac repairBas MolenaarLouk T. TimmerMarjolein DroogIlaria PeriniDanielle VersteegLieneke KooijmanJantine Monshouwer-KlootsHesther de RuiterMonika M. GladkaEva van RooijNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Bas Molenaar Louk T. Timmer Marjolein Droog Ilaria Perini Danielle Versteeg Lieneke Kooijman Jantine Monshouwer-Kloots Hesther de Ruiter Monika M. Gladka Eva van Rooij Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair
description	Molenaar et al. use scRNA-seq to profile cardiac cell gene expression changes at three time points following ischemic injury. They observe that B2M is secreted by cardiomyocytes following injury, promoting scar formation. This data may be useful in finding therapeutic targets for cardiac repair
format	article
author	Bas Molenaar Louk T. Timmer Marjolein Droog Ilaria Perini Danielle Versteeg Lieneke Kooijman Jantine Monshouwer-Kloots Hesther de Ruiter Monika M. Gladka Eva van Rooij
author_facet	Bas Molenaar Louk T. Timmer Marjolein Droog Ilaria Perini Danielle Versteeg Lieneke Kooijman Jantine Monshouwer-Kloots Hesther de Ruiter Monika M. Gladka Eva van Rooij
author_sort	Bas Molenaar
title	Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair
title_short	Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair
title_full	Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair
title_fullStr	Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair
title_full_unstemmed	Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair
title_sort	single-cell transcriptomics following ischemic injury identifies a role for b2m in cardiac repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ad3dd3f14f6498bac1a498a6c119c9c
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Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

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