Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

Food intake shapes intestinal microbiome composition, which in turn shapes adaptive immune responses. Here the authors show that dietary tryptophan restriction (DTR) protects mice from subsequent autoimmune neuropathology challenge by altering intestinal microbiota, highlighting the potential of die...

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Autores principales: Jana K. Sonner, Melanie Keil, Maren Falk-Paulsen, Neha Mishra, Ateequr Rehman, Magdalena Kramer, Katrin Deumelandt, Julian Röwe, Khwab Sanghvi, Lara Wolf, Anna von Landenberg, Hendrik Wolff, Richa Bharti, Iris Oezen, Tobias V. Lanz, Florian Wanke, Yilang Tang, Ines Brandao, Soumya R. Mohapatra, Lisa Epping, Alexandra Grill, Ralph Röth, Beate Niesler, Sven G. Meuth, Christiane A. Opitz, Jürgen G. Okun, Christoph Reinhardt, Florian C. Kurschus, Wolfgang Wick, Helge B. Bode, Philip Rosenstiel, Michael Platten
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/4ad85525c9344809af644aa890fe63d4
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Sumario:Food intake shapes intestinal microbiome composition, which in turn shapes adaptive immune responses. Here the authors show that dietary tryptophan restriction (DTR) protects mice from subsequent autoimmune neuropathology challenge by altering intestinal microbiota, highlighting the potential of diet-regulated microbiota to prevent immune pathology.

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