Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
Food intake shapes intestinal microbiome composition, which in turn shapes adaptive immune responses. Here the authors show that dietary tryptophan restriction (DTR) protects mice from subsequent autoimmune neuropathology challenge by altering intestinal microbiota, highlighting the potential of die...
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2019
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oai:doaj.org-article:4ad85525c9344809af644aa890fe63d42021-12-02T17:01:32ZDietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology10.1038/s41467-019-12776-42041-1723https://doaj.org/article/4ad85525c9344809af644aa890fe63d42019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12776-4https://doaj.org/toc/2041-1723Food intake shapes intestinal microbiome composition, which in turn shapes adaptive immune responses. Here the authors show that dietary tryptophan restriction (DTR) protects mice from subsequent autoimmune neuropathology challenge by altering intestinal microbiota, highlighting the potential of diet-regulated microbiota to prevent immune pathology.Jana K. SonnerMelanie KeilMaren Falk-PaulsenNeha MishraAteequr RehmanMagdalena KramerKatrin DeumelandtJulian RöweKhwab SanghviLara WolfAnna von LandenbergHendrik WolffRicha BhartiIris OezenTobias V. LanzFlorian WankeYilang TangInes BrandaoSoumya R. MohapatraLisa EppingAlexandra GrillRalph RöthBeate NieslerSven G. MeuthChristiane A. OpitzJürgen G. OkunChristoph ReinhardtFlorian C. KurschusWolfgang WickHelge B. BodePhilip RosenstielMichael PlattenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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Science Q |
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Science Q Jana K. Sonner Melanie Keil Maren Falk-Paulsen Neha Mishra Ateequr Rehman Magdalena Kramer Katrin Deumelandt Julian Röwe Khwab Sanghvi Lara Wolf Anna von Landenberg Hendrik Wolff Richa Bharti Iris Oezen Tobias V. Lanz Florian Wanke Yilang Tang Ines Brandao Soumya R. Mohapatra Lisa Epping Alexandra Grill Ralph Röth Beate Niesler Sven G. Meuth Christiane A. Opitz Jürgen G. Okun Christoph Reinhardt Florian C. Kurschus Wolfgang Wick Helge B. Bode Philip Rosenstiel Michael Platten Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology |
| description |
Food intake shapes intestinal microbiome composition, which in turn shapes adaptive immune responses. Here the authors show that dietary tryptophan restriction (DTR) protects mice from subsequent autoimmune neuropathology challenge by altering intestinal microbiota, highlighting the potential of diet-regulated microbiota to prevent immune pathology. |
| format |
article |
| author |
Jana K. Sonner Melanie Keil Maren Falk-Paulsen Neha Mishra Ateequr Rehman Magdalena Kramer Katrin Deumelandt Julian Röwe Khwab Sanghvi Lara Wolf Anna von Landenberg Hendrik Wolff Richa Bharti Iris Oezen Tobias V. Lanz Florian Wanke Yilang Tang Ines Brandao Soumya R. Mohapatra Lisa Epping Alexandra Grill Ralph Röth Beate Niesler Sven G. Meuth Christiane A. Opitz Jürgen G. Okun Christoph Reinhardt Florian C. Kurschus Wolfgang Wick Helge B. Bode Philip Rosenstiel Michael Platten |
| author_facet |
Jana K. Sonner Melanie Keil Maren Falk-Paulsen Neha Mishra Ateequr Rehman Magdalena Kramer Katrin Deumelandt Julian Röwe Khwab Sanghvi Lara Wolf Anna von Landenberg Hendrik Wolff Richa Bharti Iris Oezen Tobias V. Lanz Florian Wanke Yilang Tang Ines Brandao Soumya R. Mohapatra Lisa Epping Alexandra Grill Ralph Röth Beate Niesler Sven G. Meuth Christiane A. Opitz Jürgen G. Okun Christoph Reinhardt Florian C. Kurschus Wolfgang Wick Helge B. Bode Philip Rosenstiel Michael Platten |
| author_sort |
Jana K. Sonner |
| title |
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology |
| title_short |
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology |
| title_full |
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology |
| title_fullStr |
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology |
| title_full_unstemmed |
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology |
| title_sort |
dietary tryptophan links encephalogenicity of autoreactive t cells with gut microbial ecology |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4ad85525c9344809af644aa890fe63d4 |
| work_keys_str_mv |
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