Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases

Abstract Respiratory protection is key in infection prevention of airborne diseases, as highlighted by the COVID-19 pandemic for instance. Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration efficiency improvements limited by difficulty in breathing, and no safe...

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Autores principales:	Ilaria Rubino, Euna Oh, Sumin Han, Sana Kaleem, Alex Hornig, Su-Hwa Lee, Hae-Ji Kang, Dong-Hun Lee, Ki-Back Chu, Surjith Kumaran, Sarah Armstrong, Romani Lalani, Shivanjali Choudhry, Chun Il Kim, Fu-Shi Quan, Byeonghwa Jeon, Hyo-Jick Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4adbc16cdc694dc69d93954717370f86
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spelling	oai:doaj.org-article:4adbc16cdc694dc69d93954717370f862021-12-02T16:46:33ZSalt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases10.1038/s41598-020-70623-92045-2322https://doaj.org/article/4adbc16cdc694dc69d93954717370f862020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70623-9https://doaj.org/toc/2045-2322Abstract Respiratory protection is key in infection prevention of airborne diseases, as highlighted by the COVID-19 pandemic for instance. Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration efficiency improvements limited by difficulty in breathing, and no safe reusability), which have yet to be addressed in a single device. Here, we report the development of a filter overcoming the major technical challenges of respiratory protective devices. Large-pore membranes, offering high breathability but low bacteria capture, were functionalized to have a uniform salt layer on the fibers. The salt-functionalized membranes achieved high filtration efficiency as opposed to the bare membrane, with differences of up to 48%, while maintaining high breathability (> 60% increase compared to commercial surgical masks even for the thickest salt filters tested). The salt-functionalized filters quickly killed Gram-positive and Gram-negative bacteria aerosols in vitro, with CFU reductions observed as early as within 5 min, and in vivo by causing structural damage due to salt recrystallization. The salt coatings retained the pathogen inactivation capability at harsh environmental conditions (37 °C and a relative humidity of 70%, 80% and 90%). Combination of these properties in one filter will lead to the production of an effective device, comprehensibly mitigating infection transmission globally.Ilaria RubinoEuna OhSumin HanSana KaleemAlex HornigSu-Hwa LeeHae-Ji KangDong-Hun LeeKi-Back ChuSurjith KumaranSarah ArmstrongRomani LalaniShivanjali ChoudhryChun Il KimFu-Shi QuanByeonghwa JeonHyo-Jick ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilaria Rubino Euna Oh Sumin Han Sana Kaleem Alex Hornig Su-Hwa Lee Hae-Ji Kang Dong-Hun Lee Ki-Back Chu Surjith Kumaran Sarah Armstrong Romani Lalani Shivanjali Choudhry Chun Il Kim Fu-Shi Quan Byeonghwa Jeon Hyo-Jick Choi Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
description	Abstract Respiratory protection is key in infection prevention of airborne diseases, as highlighted by the COVID-19 pandemic for instance. Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration efficiency improvements limited by difficulty in breathing, and no safe reusability), which have yet to be addressed in a single device. Here, we report the development of a filter overcoming the major technical challenges of respiratory protective devices. Large-pore membranes, offering high breathability but low bacteria capture, were functionalized to have a uniform salt layer on the fibers. The salt-functionalized membranes achieved high filtration efficiency as opposed to the bare membrane, with differences of up to 48%, while maintaining high breathability (> 60% increase compared to commercial surgical masks even for the thickest salt filters tested). The salt-functionalized filters quickly killed Gram-positive and Gram-negative bacteria aerosols in vitro, with CFU reductions observed as early as within 5 min, and in vivo by causing structural damage due to salt recrystallization. The salt coatings retained the pathogen inactivation capability at harsh environmental conditions (37 °C and a relative humidity of 70%, 80% and 90%). Combination of these properties in one filter will lead to the production of an effective device, comprehensibly mitigating infection transmission globally.
format	article
author	Ilaria Rubino Euna Oh Sumin Han Sana Kaleem Alex Hornig Su-Hwa Lee Hae-Ji Kang Dong-Hun Lee Ki-Back Chu Surjith Kumaran Sarah Armstrong Romani Lalani Shivanjali Choudhry Chun Il Kim Fu-Shi Quan Byeonghwa Jeon Hyo-Jick Choi
author_facet	Ilaria Rubino Euna Oh Sumin Han Sana Kaleem Alex Hornig Su-Hwa Lee Hae-Ji Kang Dong-Hun Lee Ki-Back Chu Surjith Kumaran Sarah Armstrong Romani Lalani Shivanjali Choudhry Chun Il Kim Fu-Shi Quan Byeonghwa Jeon Hyo-Jick Choi
author_sort	Ilaria Rubino
title	Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_short	Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_full	Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_fullStr	Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_full_unstemmed	Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_sort	salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4adbc16cdc694dc69d93954717370f86
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Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases

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