Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal

Objective To investigate the relationship between serum miR-199a-5p and miR-378a-3p levels and the recurrence of infants with proliferative facial hemangioma relapsed after propranolol withdrawal in infants. Methods Ninety-three infants with proliferative facial hemangioma were selected, all of whom...

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Autores principales:	GUO Yan, ZHANG Kai, FAN Xuhui, LI Lifeng
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases 2022
Materias:	micro ribonucleic acid mir-199a-5p mir-378a-3p propranolol infant hemangioma recurrence endothelial cell proliferation Medicine R
Acceso en línea:	https://doaj.org/article/4ae03ff196204d588a494b32a035243a
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spelling	oai:doaj.org-article:4ae03ff196204d588a494b32a035243a2021-11-25T07:18:56ZRelationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal10.12016/j.issn.2096-1456.2022.02.0042096-1456https://doaj.org/article/4ae03ff196204d588a494b32a035243a2022-02-01T00:00:00Zhttp://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.02.004https://doaj.org/toc/2096-1456Objective To investigate the relationship between serum miR-199a-5p and miR-378a-3p levels and the recurrence of infants with proliferative facial hemangioma relapsed after propranolol withdrawal in infants. Methods Ninety-three infants with proliferative facial hemangioma were selected, all of whom received propranolol treatment. The recurrence of the hemangioma after treatment was followed up, and the children were divided into a recurrence group (23 patients) and a nonrecurrence group (70 patients). Venous blood was collected before and after treatment, and the serum levels of miR-199a-5p and miR-378a-3p were detected by qRT-PCR, and the relationship between the serum levels of miR-199a-5p and miR-378a-3p and the recurrence of proliferative facial hemangioma relapsed after propranolol withdrawal in infants was analyzed. Results The serum expressions levels of miR-199a-5p and miR-378a-3p in non-relapsed group were increased after treatment compared with before treatment (P < 0.05), and there was no significant difference in the levels of miR-199a-5p and miR-378a-3p in the serum of the recurrence group after treatment compared with before treatment (P > 0.05). After treatment, the levels of miR-199a-5p and miR-378a-3p in the serum of the recurrence group were lower than those of the nonrecurrence group (P < 0.05). After treatment, the serum levels of miR-199a-5p and miR-378a-3p in patients with Ⅲ ~Ⅳ Norm grade hemangioma were higher than those in patients with Ⅰ~Ⅱ Norm grade hemangioma (P < 0.05). Logistic regression analysis showed that the low expression of miR-199a-5p, low expression of miR-378a-3p and tumor grade Ⅰ~Ⅱ after treatment were risk factors for the recurrence of proliferative facial hemangioma after propranolol withdrawal in infants (P < 0.05). Conclusion Low serum levels of miR-199a-5p and miR-378a-3p are associated with the recurrence of proliferative facial hemangioma after propranolol withdrawal in infants.GUO YanZHANG Kai FAN XuhuiLI LifengEditorial Department of Journal of Prevention and Treatment for Stomatological Diseasesarticlemicro ribonucleic acidmir-199a-5pmir-378a-3ppropranololinfanthemangiomarecurrenceendothelial cell proliferationMedicineRZH口腔疾病防治, Vol 30, Iss 2, Pp 97-102 (2022)
institution	DOAJ
collection	DOAJ
language	ZH
topic	micro ribonucleic acid mir-199a-5p mir-378a-3p propranolol infant hemangioma recurrence endothelial cell proliferation Medicine R
spellingShingle	micro ribonucleic acid mir-199a-5p mir-378a-3p propranolol infant hemangioma recurrence endothelial cell proliferation Medicine R GUO Yan ZHANG Kai FAN Xuhui LI Lifeng Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal
description	Objective To investigate the relationship between serum miR-199a-5p and miR-378a-3p levels and the recurrence of infants with proliferative facial hemangioma relapsed after propranolol withdrawal in infants. Methods Ninety-three infants with proliferative facial hemangioma were selected, all of whom received propranolol treatment. The recurrence of the hemangioma after treatment was followed up, and the children were divided into a recurrence group (23 patients) and a nonrecurrence group (70 patients). Venous blood was collected before and after treatment, and the serum levels of miR-199a-5p and miR-378a-3p were detected by qRT-PCR, and the relationship between the serum levels of miR-199a-5p and miR-378a-3p and the recurrence of proliferative facial hemangioma relapsed after propranolol withdrawal in infants was analyzed. Results The serum expressions levels of miR-199a-5p and miR-378a-3p in non-relapsed group were increased after treatment compared with before treatment (P < 0.05), and there was no significant difference in the levels of miR-199a-5p and miR-378a-3p in the serum of the recurrence group after treatment compared with before treatment (P > 0.05). After treatment, the levels of miR-199a-5p and miR-378a-3p in the serum of the recurrence group were lower than those of the nonrecurrence group (P < 0.05). After treatment, the serum levels of miR-199a-5p and miR-378a-3p in patients with Ⅲ ~Ⅳ Norm grade hemangioma were higher than those in patients with Ⅰ~Ⅱ Norm grade hemangioma (P < 0.05). Logistic regression analysis showed that the low expression of miR-199a-5p, low expression of miR-378a-3p and tumor grade Ⅰ~Ⅱ after treatment were risk factors for the recurrence of proliferative facial hemangioma after propranolol withdrawal in infants (P < 0.05). Conclusion Low serum levels of miR-199a-5p and miR-378a-3p are associated with the recurrence of proliferative facial hemangioma after propranolol withdrawal in infants.
format	article
author	GUO Yan ZHANG Kai FAN Xuhui LI Lifeng
author_facet	GUO Yan ZHANG Kai FAN Xuhui LI Lifeng
author_sort	GUO Yan
title	Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal
title_short	Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal
title_full	Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal
title_fullStr	Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal
title_full_unstemmed	Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal
title_sort	relationship between serum mir-199a-5p and mir-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal
publisher	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
publishDate	2022
url	https://doaj.org/article/4ae03ff196204d588a494b32a035243a
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Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal

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