Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2

Background. Hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) are the common diagnostic/prognostic markers in breast cancer. Few articles have recently reported the correlation between cytology and molecular subtypes. We combined nuclear morphological characteristics with HR...

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Autores principales:	Jiayu Li, Yehan Zhou, Yunzhu Li, Yang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/4ae2724fcd4c45f7806fe48d53564009
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spelling	oai:doaj.org-article:4ae2724fcd4c45f7806fe48d535640092021-11-22T01:09:47ZNuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 22210-718510.1155/2021/3037993https://doaj.org/article/4ae2724fcd4c45f7806fe48d535640092021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3037993https://doaj.org/toc/2210-7185Background. Hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) are the common diagnostic/prognostic markers in breast cancer. Few articles have recently reported the correlation between cytology and molecular subtypes. We combined nuclear morphological characteristics with HR and HER2 status to observe the relationship and provide ideas for machine learning. Methods. We reanalyzed fine-needle aspiration cytology samples and core-needle puncture histological specimens from 142 patients with invasive breast cancer between March 2019 and December 2019, and the findings were compared with the two groups (HR+/HER2- and HR-/HER2+) following nuclear cytomorphological features: nuclear/cytoplasmic ratio, difference of nuclear size, nuclear pleomorphism, chromatin feature, nuclear membrane and nucleoli, and Nottingham grading. Results. Two groups were significantly associated with the difference of nuclear size, nuclear pleomorphism, and nucleoli (P<0.001) and consistent with histological grading (P<0.001). Moreover, nucleolar characteristics of size and number had obviously statistical significance (P<0.001). Multiple micro-nucleoli were frequently seen in the HR+/HER2- group compared with the HR-/HER2+ group which mostly were observed centered medium-large nucleoli. We described four interesting nuclear morphologies in the experiment. Conclusions. There were significant differences in nuclear characteristics between two groups. HR and HER2 status not only might be predicted in cytological samples, but some specific nuclear morphological features might have potential value to help us understand molecular function and predict more information.Jiayu LiYehan ZhouYunzhu LiYang LiuHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENAnalytical Cellular Pathology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Jiayu Li Yehan Zhou Yunzhu Li Yang Liu Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2
description	Background. Hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) are the common diagnostic/prognostic markers in breast cancer. Few articles have recently reported the correlation between cytology and molecular subtypes. We combined nuclear morphological characteristics with HR and HER2 status to observe the relationship and provide ideas for machine learning. Methods. We reanalyzed fine-needle aspiration cytology samples and core-needle puncture histological specimens from 142 patients with invasive breast cancer between March 2019 and December 2019, and the findings were compared with the two groups (HR+/HER2- and HR-/HER2+) following nuclear cytomorphological features: nuclear/cytoplasmic ratio, difference of nuclear size, nuclear pleomorphism, chromatin feature, nuclear membrane and nucleoli, and Nottingham grading. Results. Two groups were significantly associated with the difference of nuclear size, nuclear pleomorphism, and nucleoli (P<0.001) and consistent with histological grading (P<0.001). Moreover, nucleolar characteristics of size and number had obviously statistical significance (P<0.001). Multiple micro-nucleoli were frequently seen in the HR+/HER2- group compared with the HR-/HER2+ group which mostly were observed centered medium-large nucleoli. We described four interesting nuclear morphologies in the experiment. Conclusions. There were significant differences in nuclear characteristics between two groups. HR and HER2 status not only might be predicted in cytological samples, but some specific nuclear morphological features might have potential value to help us understand molecular function and predict more information.
format	article
author	Jiayu Li Yehan Zhou Yunzhu Li Yang Liu
author_facet	Jiayu Li Yehan Zhou Yunzhu Li Yang Liu
author_sort	Jiayu Li
title	Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2
title_short	Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2
title_full	Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2
title_fullStr	Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2
title_full_unstemmed	Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2
title_sort	nuclear morphological characteristics in breast cancer: correlation with hormone receptor and human epidermal growth factor receptor 2
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/4ae2724fcd4c45f7806fe48d53564009
work_keys_str_mv	AT jiayuli nuclearmorphologicalcharacteristicsinbreastcancercorrelationwithhormonereceptorandhumanepidermalgrowthfactorreceptor2 AT yehanzhou nuclearmorphologicalcharacteristicsinbreastcancercorrelationwithhormonereceptorandhumanepidermalgrowthfactorreceptor2 AT yunzhuli nuclearmorphologicalcharacteristicsinbreastcancercorrelationwithhormonereceptorandhumanepidermalgrowthfactorreceptor2 AT yangliu nuclearmorphologicalcharacteristicsinbreastcancercorrelationwithhormonereceptorandhumanepidermalgrowthfactorreceptor2
_version_	1718418397728866304

Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2

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