Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVH...

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Auteurs principaux:	Ruishu Deng, Christian Hurtz, Qingxiao Song, Chanyu Yue, Gang Xiao, Hua Yu, Xiwei Wu, Markus Muschen, Stephen Forman, Paul J. Martin, Defu Zeng
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/4ae9ab1b935340a8a29b9c8d5a7b619c
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spelling	oai:doaj.org-article:4ae9ab1b935340a8a29b9c8d5a7b619c2021-12-02T15:38:45ZExtrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease10.1038/s41467-017-00880-22041-1723https://doaj.org/article/4ae9ab1b935340a8a29b9c8d5a7b619c2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00880-2https://doaj.org/toc/2041-1723Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVHD while GC is dispensable.Ruishu DengChristian HurtzQingxiao SongChanyu YueGang XiaoHua YuXiwei WuMarkus MuschenStephen FormanPaul J. MartinDefu ZengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruishu Deng Christian Hurtz Qingxiao Song Chanyu Yue Gang Xiao Hua Yu Xiwei Wu Markus Muschen Stephen Forman Paul J. Martin Defu Zeng Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
description	Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVHD while GC is dispensable.
format	article
author	Ruishu Deng Christian Hurtz Qingxiao Song Chanyu Yue Gang Xiao Hua Yu Xiwei Wu Markus Muschen Stephen Forman Paul J. Martin Defu Zeng
author_facet	Ruishu Deng Christian Hurtz Qingxiao Song Chanyu Yue Gang Xiao Hua Yu Xiwei Wu Markus Muschen Stephen Forman Paul J. Martin Defu Zeng
author_sort	Ruishu Deng
title	Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
title_short	Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
title_full	Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
title_fullStr	Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
title_full_unstemmed	Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
title_sort	extrafollicular cd4+ t-b interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4ae9ab1b935340a8a29b9c8d5a7b619c
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Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

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