A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

A vaccine preventing infection and transmission of SARS-CoV-2 is needed. Here, Wu et al. generate an adenovirus-vector vaccine expressing SARS-CoV-2 spike protein and show that a single dose of mucosal vaccination protects mice and ferrets from infection and inhibits virus replication in the upper r...

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Autores principales: Shipo Wu, Gongxun Zhong, Jun Zhang, Lei Shuai, Zhe Zhang, Zhiyuan Wen, Busen Wang, Zhenghao Zhao, Xiaohong Song, Yi Chen, Renqiang Liu, Ling Fu, Jinlong Zhang, Qiang Guo, Chong Wang, Yilong Yang, Ting Fang, Peng Lv, Jinliang Wang, Junjie Xu, Jianmin Li, Changming Yu, Lihua Hou, Zhigao Bu, Wei Chen
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/4aef5f7200f7436682a8691431a0aedd
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spelling oai:doaj.org-article:4aef5f7200f7436682a8691431a0aedd2021-12-02T18:50:45ZA single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge10.1038/s41467-020-17972-12041-1723https://doaj.org/article/4aef5f7200f7436682a8691431a0aedd2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17972-1https://doaj.org/toc/2041-1723A vaccine preventing infection and transmission of SARS-CoV-2 is needed. Here, Wu et al. generate an adenovirus-vector vaccine expressing SARS-CoV-2 spike protein and show that a single dose of mucosal vaccination protects mice and ferrets from infection and inhibits virus replication in the upper respiratory tract.Shipo WuGongxun ZhongJun ZhangLei ShuaiZhe ZhangZhiyuan WenBusen WangZhenghao ZhaoXiaohong SongYi ChenRenqiang LiuLing FuJinlong ZhangQiang GuoChong WangYilong YangTing FangPeng LvJinliang WangJunjie XuJianmin LiChangming YuLihua HouZhigao BuWei ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shipo Wu
Gongxun Zhong
Jun Zhang
Lei Shuai
Zhe Zhang
Zhiyuan Wen
Busen Wang
Zhenghao Zhao
Xiaohong Song
Yi Chen
Renqiang Liu
Ling Fu
Jinlong Zhang
Qiang Guo
Chong Wang
Yilong Yang
Ting Fang
Peng Lv
Jinliang Wang
Junjie Xu
Jianmin Li
Changming Yu
Lihua Hou
Zhigao Bu
Wei Chen
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
description A vaccine preventing infection and transmission of SARS-CoV-2 is needed. Here, Wu et al. generate an adenovirus-vector vaccine expressing SARS-CoV-2 spike protein and show that a single dose of mucosal vaccination protects mice and ferrets from infection and inhibits virus replication in the upper respiratory tract.
format article
author Shipo Wu
Gongxun Zhong
Jun Zhang
Lei Shuai
Zhe Zhang
Zhiyuan Wen
Busen Wang
Zhenghao Zhao
Xiaohong Song
Yi Chen
Renqiang Liu
Ling Fu
Jinlong Zhang
Qiang Guo
Chong Wang
Yilong Yang
Ting Fang
Peng Lv
Jinliang Wang
Junjie Xu
Jianmin Li
Changming Yu
Lihua Hou
Zhigao Bu
Wei Chen
author_facet Shipo Wu
Gongxun Zhong
Jun Zhang
Lei Shuai
Zhe Zhang
Zhiyuan Wen
Busen Wang
Zhenghao Zhao
Xiaohong Song
Yi Chen
Renqiang Liu
Ling Fu
Jinlong Zhang
Qiang Guo
Chong Wang
Yilong Yang
Ting Fang
Peng Lv
Jinliang Wang
Junjie Xu
Jianmin Li
Changming Yu
Lihua Hou
Zhigao Bu
Wei Chen
author_sort Shipo Wu
title A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_short A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_full A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_fullStr A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_full_unstemmed A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_sort single dose of an adenovirus-vectored vaccine provides protection against sars-cov-2 challenge
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/4aef5f7200f7436682a8691431a0aedd
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