The giant protein titin regulates the length of the striated muscle thick filament

Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.

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Autores principales:	Paola Tonino, Balazs Kiss, Josh Strom, Mei Methawasin, John E. Smith, Justin Kolb, Siegfried Labeit, Henk Granzier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4aefdc45145b406c95a8fd2a8dd9dabe
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spelling	oai:doaj.org-article:4aefdc45145b406c95a8fd2a8dd9dabe2021-12-02T15:38:45ZThe giant protein titin regulates the length of the striated muscle thick filament10.1038/s41467-017-01144-92041-1723https://doaj.org/article/4aefdc45145b406c95a8fd2a8dd9dabe2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01144-9https://doaj.org/toc/2041-1723Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.Paola ToninoBalazs KissJosh StromMei MethawasinJohn E. SmithJustin KolbSiegfried LabeitHenk GranzierNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paola Tonino Balazs Kiss Josh Strom Mei Methawasin John E. Smith Justin Kolb Siegfried Labeit Henk Granzier The giant protein titin regulates the length of the striated muscle thick filament
description	Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.
format	article
author	Paola Tonino Balazs Kiss Josh Strom Mei Methawasin John E. Smith Justin Kolb Siegfried Labeit Henk Granzier
author_facet	Paola Tonino Balazs Kiss Josh Strom Mei Methawasin John E. Smith Justin Kolb Siegfried Labeit Henk Granzier
author_sort	Paola Tonino
title	The giant protein titin regulates the length of the striated muscle thick filament
title_short	The giant protein titin regulates the length of the striated muscle thick filament
title_full	The giant protein titin regulates the length of the striated muscle thick filament
title_fullStr	The giant protein titin regulates the length of the striated muscle thick filament
title_full_unstemmed	The giant protein titin regulates the length of the striated muscle thick filament
title_sort	giant protein titin regulates the length of the striated muscle thick filament
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4aefdc45145b406c95a8fd2a8dd9dabe
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The giant protein titin regulates the length of the striated muscle thick filament

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