Impact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis

Salimah H Meghani,1,2 Ryan Quinn,1 Rebecca Ashare,3,4 Kristin Levoy,1,5,6 Brooke Worster,7 Mary Naylor,1,2 Jesse Chittams,1 Martin Cheatle8 1Department of Biobehavioral Health Sciences, NewCourtland Center for Transitions and Health, School of Nursing, University of Pennsylvania, Philadelphia, PA, U...

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Autores principales:	Meghani SH, Quinn R, Ashare R, Levoy K, Worster B, Naylor M, Chittams J, Cheatle M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	pain cancer pain pain relief pain disparities cannabis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4af033ffd9eb4a0cb381360b5eb73d34
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spelling	oai:doaj.org-article:4af033ffd9eb4a0cb381360b5eb73d342021-11-07T18:42:56ZImpact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis1178-7090https://doaj.org/article/4af033ffd9eb4a0cb381360b5eb73d342021-11-01T00:00:00Zhttps://www.dovepress.com/impact-of-cannabis-use-on-least-pain-scores-among-african-american-and-peer-reviewed-fulltext-article-JPRhttps://doaj.org/toc/1178-7090Salimah H Meghani,1,2 Ryan Quinn,1 Rebecca Ashare,3,4 Kristin Levoy,1,5,6 Brooke Worster,7 Mary Naylor,1,2 Jesse Chittams,1 Martin Cheatle8 1Department of Biobehavioral Health Sciences, NewCourtland Center for Transitions and Health, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA; 2Leonard Davis Institute for Health Economics, University of Pennsylvania, Philadelphia, PA, USA; 3Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 4Department of Psychology, State University of New York at Buffalo, Buffalo, NY, USA; 5Department of Community and Health Systems, School of Nursing, Indiana University, Indianapolis, IN, USA; 6Center for Aging Research, Regenstrief Institute, Indianapolis, IN, USA; 7Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA; 8Department of Psychiatry and Anesthesiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACorrespondence: Salimah H MeghaniDepartment of Biobehavioral Health Sciences, NewCourtland Center for Transitions and Health, Leonard Davis Institute for Health Economics, University of Pennsylvania, Philadelphia, PA, USATel +215 573-7128Email meghanis@nursing.upenn.eduIntroduction: Based on many published reports, African American patients with cancer experience higher pain severity scores and lower pain relief than White patients. This disparity results from undertreatment of pain and is compounded by low adherence to prescribed non-opioid and opioid analgesics among African American patients with cancer. While nearly one in four patients use cannabis to manage cancer-related symptoms, less is known about how cannabis use influences pain relief in this patient population.Methods: This study is based on preliminary data from an ongoing study of longitudinal outcomes of opioid therapy among African American and White patients with cancer. Linear mixed-effects models were utilized to assess the interaction of race and cannabis use on pain relief using “least pain” item scores from the Brief Pain Inventory (BPI) averaged across three time points. Models were adjusted for sociodemographic and clinical variables.Results: This analysis included 136 patients (49 African American, 87 White). Overall, 30.1% of the sample reported cannabis use for cancer pain. The mean “least pain” score on BPI was 3.3 (SD=2.42) on a scale of 0– 10. African American patients had a mean “least pain” score 1.32± 0.48 units higher (indicating lower pain relief) than White patients (p=0.006). Cannabis use did not have a significant main effect (p=0.28). However, cannabis use was a significant moderator of the relationship between race and “least pain” (p=0.03). In the absence of cannabis use, African Americans reported higher “least pain” scores compared to Whites (mean difference=1.631± 0.5, p=0.001). However, this disparity was no longer observed in African American patients reporting cannabis use (mean “least pain” difference=0.587± 0.59, p=0.32).Conclusion: These findings point to the possible role of cannabis in cancer pain management and its potential to reduce racial disparities. These findings are preliminary and further research into the role of cannabis in cancer pain outcomes is needed.Keywords: pain, cancer pain, pain relief, pain disparities, cannabisMeghani SHQuinn RAshare RLevoy KWorster BNaylor MChittams JCheatle MDove Medical Pressarticlepaincancer painpain reliefpain disparitiescannabisMedicine (General)R5-920ENJournal of Pain Research, Vol Volume 14, Pp 3493-3502 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pain cancer pain pain relief pain disparities cannabis Medicine (General) R5-920
spellingShingle	pain cancer pain pain relief pain disparities cannabis Medicine (General) R5-920 Meghani SH Quinn R Ashare R Levoy K Worster B Naylor M Chittams J Cheatle M Impact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis
description	Salimah H Meghani,1,2 Ryan Quinn,1 Rebecca Ashare,3,4 Kristin Levoy,1,5,6 Brooke Worster,7 Mary Naylor,1,2 Jesse Chittams,1 Martin Cheatle8 1Department of Biobehavioral Health Sciences, NewCourtland Center for Transitions and Health, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA; 2Leonard Davis Institute for Health Economics, University of Pennsylvania, Philadelphia, PA, USA; 3Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 4Department of Psychology, State University of New York at Buffalo, Buffalo, NY, USA; 5Department of Community and Health Systems, School of Nursing, Indiana University, Indianapolis, IN, USA; 6Center for Aging Research, Regenstrief Institute, Indianapolis, IN, USA; 7Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA; 8Department of Psychiatry and Anesthesiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACorrespondence: Salimah H MeghaniDepartment of Biobehavioral Health Sciences, NewCourtland Center for Transitions and Health, Leonard Davis Institute for Health Economics, University of Pennsylvania, Philadelphia, PA, USATel +215 573-7128Email meghanis@nursing.upenn.eduIntroduction: Based on many published reports, African American patients with cancer experience higher pain severity scores and lower pain relief than White patients. This disparity results from undertreatment of pain and is compounded by low adherence to prescribed non-opioid and opioid analgesics among African American patients with cancer. While nearly one in four patients use cannabis to manage cancer-related symptoms, less is known about how cannabis use influences pain relief in this patient population.Methods: This study is based on preliminary data from an ongoing study of longitudinal outcomes of opioid therapy among African American and White patients with cancer. Linear mixed-effects models were utilized to assess the interaction of race and cannabis use on pain relief using “least pain” item scores from the Brief Pain Inventory (BPI) averaged across three time points. Models were adjusted for sociodemographic and clinical variables.Results: This analysis included 136 patients (49 African American, 87 White). Overall, 30.1% of the sample reported cannabis use for cancer pain. The mean “least pain” score on BPI was 3.3 (SD=2.42) on a scale of 0– 10. African American patients had a mean “least pain” score 1.32± 0.48 units higher (indicating lower pain relief) than White patients (p=0.006). Cannabis use did not have a significant main effect (p=0.28). However, cannabis use was a significant moderator of the relationship between race and “least pain” (p=0.03). In the absence of cannabis use, African Americans reported higher “least pain” scores compared to Whites (mean difference=1.631± 0.5, p=0.001). However, this disparity was no longer observed in African American patients reporting cannabis use (mean “least pain” difference=0.587± 0.59, p=0.32).Conclusion: These findings point to the possible role of cannabis in cancer pain management and its potential to reduce racial disparities. These findings are preliminary and further research into the role of cannabis in cancer pain outcomes is needed.Keywords: pain, cancer pain, pain relief, pain disparities, cannabis
format	article
author	Meghani SH Quinn R Ashare R Levoy K Worster B Naylor M Chittams J Cheatle M
author_facet	Meghani SH Quinn R Ashare R Levoy K Worster B Naylor M Chittams J Cheatle M
author_sort	Meghani SH
title	Impact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis
title_short	Impact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis
title_full	Impact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis
title_fullStr	Impact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis
title_full_unstemmed	Impact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis
title_sort	impact of cannabis use on least pain scores among african american and white patients with cancer pain: a moderation analysis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4af033ffd9eb4a0cb381360b5eb73d34
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Impact of Cannabis Use on Least Pain Scores Among African American and White Patients with Cancer Pain: A Moderation Analysis

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