RELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS

The article aims for description of glandular/lymphoid interactions within digestive tract over the postnatal ontogenesis which is of special importance for clinical immunology. We have examined lingual salivary glands obtained from 299 autopsies, using macroscopic and histological techniques. Their...

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Autores principales:	A. V. Olsufieva, I. V. Bodrova, K. A. Vasyanina, S. S. Olsufiev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	oral cavity local immunity lymphoid tissue salivary glands tongue pharynx secretory iga Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4af975a5f645432c940c3348e3d01d80
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spelling	oai:doaj.org-article:4af975a5f645432c940c3348e3d01d802021-11-18T08:03:48ZRELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS1563-06252313-741X10.15789/1563-0625-2019-5-981-986https://doaj.org/article/4af975a5f645432c940c3348e3d01d802019-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1614https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe article aims for description of glandular/lymphoid interactions within digestive tract over the postnatal ontogenesis which is of special importance for clinical immunology. We have examined lingual salivary glands obtained from 299 autopsies, using macroscopic and histological techniques. Their age ranged from newborns to senile individuals; both males and females were included. The biological material was sampled at the local pathology departments at the Moscow Bureau for Forensic and Medical Expertise, according to approval by Russian federal law (No. 323, art. 47, 4180-1, 355н). The cases with pathological changes of digestive system revealed upon autopsies were excluded from evaluation. The transverse tissue sections were stained with H&E and picro fuchsin by van Gieson technique.The minor salivary lingual and pharyngeal glands, being located in the depth of tongue and pharyngeal walls, perform an important endocrine function, i.e they participate in oral immunity responses. A lot of publications concerns regenerative changes of oral mucosa caused by secretory IgA which plays a main role in regulation of local immunity. The article describes important age-dependent changes of both lingual and pharyngeal minor salivary glands. Typical scarcity of the glands in childhood may be caused by the uniform nutrition at this age, whereas decreased secretory IgA production, is generally leading to development of common inflammatory events in the oropharyngeal area. With increasing age, the glandular apertures become wider and more numerous, thus leading to increased local immunity in oral cavity and oropharynx. Sufficient involutional changes are observed in old and senile age cohorts, accompanied by diminished secretory IgA production, and, respectively, by decreased indexes of local and humoral immunity. These results are entirely reflecting topographical interrelations between the glands and lymphoid cells, and appropriate data are quite important for clinical immunology.A. V. OlsufievaI. V. BodrovaK. A. VasyaninaS. S. OlsufievSPb RAACIarticleoral cavitylocal immunitylymphoid tissuesalivary glandstonguepharynxsecretory igaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 5, Pp 981-986 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	oral cavity local immunity lymphoid tissue salivary glands tongue pharynx secretory iga Immunologic diseases. Allergy RC581-607
spellingShingle	oral cavity local immunity lymphoid tissue salivary glands tongue pharynx secretory iga Immunologic diseases. Allergy RC581-607 A. V. Olsufieva I. V. Bodrova K. A. Vasyanina S. S. Olsufiev RELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS
description	The article aims for description of glandular/lymphoid interactions within digestive tract over the postnatal ontogenesis which is of special importance for clinical immunology. We have examined lingual salivary glands obtained from 299 autopsies, using macroscopic and histological techniques. Their age ranged from newborns to senile individuals; both males and females were included. The biological material was sampled at the local pathology departments at the Moscow Bureau for Forensic and Medical Expertise, according to approval by Russian federal law (No. 323, art. 47, 4180-1, 355н). The cases with pathological changes of digestive system revealed upon autopsies were excluded from evaluation. The transverse tissue sections were stained with H&E and picro fuchsin by van Gieson technique.The minor salivary lingual and pharyngeal glands, being located in the depth of tongue and pharyngeal walls, perform an important endocrine function, i.e they participate in oral immunity responses. A lot of publications concerns regenerative changes of oral mucosa caused by secretory IgA which plays a main role in regulation of local immunity. The article describes important age-dependent changes of both lingual and pharyngeal minor salivary glands. Typical scarcity of the glands in childhood may be caused by the uniform nutrition at this age, whereas decreased secretory IgA production, is generally leading to development of common inflammatory events in the oropharyngeal area. With increasing age, the glandular apertures become wider and more numerous, thus leading to increased local immunity in oral cavity and oropharynx. Sufficient involutional changes are observed in old and senile age cohorts, accompanied by diminished secretory IgA production, and, respectively, by decreased indexes of local and humoral immunity. These results are entirely reflecting topographical interrelations between the glands and lymphoid cells, and appropriate data are quite important for clinical immunology.
format	article
author	A. V. Olsufieva I. V. Bodrova K. A. Vasyanina S. S. Olsufiev
author_facet	A. V. Olsufieva I. V. Bodrova K. A. Vasyanina S. S. Olsufiev
author_sort	A. V. Olsufieva
title	RELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS
title_short	RELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS
title_full	RELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS
title_fullStr	RELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS
title_full_unstemmed	RELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS
title_sort	relationships between glandular and lymphoid tissues in human tongue and pharyngeal walls in postnatal ontogenesis
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/4af975a5f645432c940c3348e3d01d80
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_version_	1718422346184785920

RELATIONSHIPS BETWEEN GLANDULAR AND LYMPHOID TISSUES IN HUMAN TONGUE AND PHARYNGEAL WALLS IN POSTNATAL ONTOGENESIS

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