Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans

Abstract Heart rate and heart rate variability (HRV) are mainly determined by the autonomic nervous system (ANS), which interacts with receptors on the sinoatrial node (SAN; the heart’s primary pacemaker), and by the “coupled-clock” system within the SAN cells. HRV changes are associated with cardia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aviv A. Rosenberg, Ido Weiser-Bitoun, George E. Billman, Yael Yaniv
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4afd82beb86c463a967efcb1d6583621
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4afd82beb86c463a967efcb1d6583621
record_format	dspace
spelling	oai:doaj.org-article:4afd82beb86c463a967efcb1d65836212021-12-02T17:41:09ZSignatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans10.1038/s41598-020-66709-z2045-2322https://doaj.org/article/4afd82beb86c463a967efcb1d65836212020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66709-zhttps://doaj.org/toc/2045-2322Abstract Heart rate and heart rate variability (HRV) are mainly determined by the autonomic nervous system (ANS), which interacts with receptors on the sinoatrial node (SAN; the heart’s primary pacemaker), and by the “coupled-clock” system within the SAN cells. HRV changes are associated with cardiac diseases. However, the relative contributions of the ANS and SAN to HRV are not clear, impeding effective treatment. To discern the SAN’s contribution, we performed HRV analysis on canine electrocardiograms containing basal and ANS-blockade segments. We also analyzed human electrocardiograms of atrial fibrillation and heart failure patients, as well as healthy aged subjects. Finally, we used a mathematical model to simulate HRV under decreased “coupled-clock” regulation. We found that (a) in canines, the SAN and ANS contribute mainly to long- and short-term HRV, respectively; (b) there is evidence suggesting a similar relative SAN contribution in humans; (c) SAN features can be calculated from beat-intervals obtained in-vivo, without intervention; (d) ANS contribution can be modeled by sines embedded in white noise; (e) HRV changes associated with cardiac diseases and aging can be interpreted as deterioration of both SAN and ANS; and (f) SAN clock-coupling can be estimated from changes in HRV. This may enable future non-invasive diagnostic applications.Aviv A. RosenbergIdo Weiser-BitounGeorge E. BillmanYael YanivNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aviv A. Rosenberg Ido Weiser-Bitoun George E. Billman Yael Yaniv Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans
description	Abstract Heart rate and heart rate variability (HRV) are mainly determined by the autonomic nervous system (ANS), which interacts with receptors on the sinoatrial node (SAN; the heart’s primary pacemaker), and by the “coupled-clock” system within the SAN cells. HRV changes are associated with cardiac diseases. However, the relative contributions of the ANS and SAN to HRV are not clear, impeding effective treatment. To discern the SAN’s contribution, we performed HRV analysis on canine electrocardiograms containing basal and ANS-blockade segments. We also analyzed human electrocardiograms of atrial fibrillation and heart failure patients, as well as healthy aged subjects. Finally, we used a mathematical model to simulate HRV under decreased “coupled-clock” regulation. We found that (a) in canines, the SAN and ANS contribute mainly to long- and short-term HRV, respectively; (b) there is evidence suggesting a similar relative SAN contribution in humans; (c) SAN features can be calculated from beat-intervals obtained in-vivo, without intervention; (d) ANS contribution can be modeled by sines embedded in white noise; (e) HRV changes associated with cardiac diseases and aging can be interpreted as deterioration of both SAN and ANS; and (f) SAN clock-coupling can be estimated from changes in HRV. This may enable future non-invasive diagnostic applications.
format	article
author	Aviv A. Rosenberg Ido Weiser-Bitoun George E. Billman Yael Yaniv
author_facet	Aviv A. Rosenberg Ido Weiser-Bitoun George E. Billman Yael Yaniv
author_sort	Aviv A. Rosenberg
title	Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans
title_short	Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans
title_full	Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans
title_fullStr	Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans
title_full_unstemmed	Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans
title_sort	signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4afd82beb86c463a967efcb1d6583621
work_keys_str_mv	AT avivarosenberg signaturesoftheautonomicnervoussystemandtheheartspacemakercellsincanineelectrocardiogramsandtheirapplicationstohumans AT idoweiserbitoun signaturesoftheautonomicnervoussystemandtheheartspacemakercellsincanineelectrocardiogramsandtheirapplicationstohumans AT georgeebillman signaturesoftheautonomicnervoussystemandtheheartspacemakercellsincanineelectrocardiogramsandtheirapplicationstohumans AT yaelyaniv signaturesoftheautonomicnervoussystemandtheheartspacemakercellsincanineelectrocardiogramsandtheirapplicationstohumans
_version_	1718379702624714752

Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans

Ejemplares similares