High expression of microRNA-126 relates to favorable prognosis for colon cancer patients

Abstract miR-126 has been identified both as a tumor suppressor and an oncogene in different types of cancer. The aim of this study was to investigate the prognostic impact of miR-126-expression in colon cancer patients. Tumor tissue from 452 patients operated for stage I–III colon cancer was retros...

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Autores principales:	Hallgeir Selven, Lill-Tove Rasmussen Busund, Sigve Andersen, Roy M. Bremnes, Thomas Karsten Kilvær
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4afe9c4e77834484b4e5ef64578b98fd
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spelling	oai:doaj.org-article:4afe9c4e77834484b4e5ef64578b98fd2021-12-02T15:38:11ZHigh expression of microRNA-126 relates to favorable prognosis for colon cancer patients10.1038/s41598-021-87985-32045-2322https://doaj.org/article/4afe9c4e77834484b4e5ef64578b98fd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87985-3https://doaj.org/toc/2045-2322Abstract miR-126 has been identified both as a tumor suppressor and an oncogene in different types of cancer. The aim of this study was to investigate the prognostic impact of miR-126-expression in colon cancer patients. Tumor tissue from 452 patients operated for stage I–III colon cancer was retrospectively collected and tissue microarrays were constructed. miR-126 expression was evaluated by in situ hybridization and analyzed using digital pathology. To isolate the compartment specific contribution of miR-126, tumor and adjacent tumor stroma were considered separately. In univariate analyses, high expression of miR-126 in tumor and stroma was related to increased disease-specific survival (p < 0.001 and p = 0.005, respectively). In multivariate analyses, high miR-126 expression in tumor remained a significant independent predictor of improved disease-specific survival (HR = 0.42, CI 0.23–0.75, p = 0.004). Within different TNM-stages there was a tendency towards the same results, but with statistically significant results in stage II only (p = 0.007). High expression of miR-126 is an independent positive prognostic factor in stage I–III colon cancer. This finding may be used to identify patients in need of adjuvant chemotherapy.Hallgeir SelvenLill-Tove Rasmussen BusundSigve AndersenRoy M. BremnesThomas Karsten KilværNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hallgeir Selven Lill-Tove Rasmussen Busund Sigve Andersen Roy M. Bremnes Thomas Karsten Kilvær High expression of microRNA-126 relates to favorable prognosis for colon cancer patients
description	Abstract miR-126 has been identified both as a tumor suppressor and an oncogene in different types of cancer. The aim of this study was to investigate the prognostic impact of miR-126-expression in colon cancer patients. Tumor tissue from 452 patients operated for stage I–III colon cancer was retrospectively collected and tissue microarrays were constructed. miR-126 expression was evaluated by in situ hybridization and analyzed using digital pathology. To isolate the compartment specific contribution of miR-126, tumor and adjacent tumor stroma were considered separately. In univariate analyses, high expression of miR-126 in tumor and stroma was related to increased disease-specific survival (p < 0.001 and p = 0.005, respectively). In multivariate analyses, high miR-126 expression in tumor remained a significant independent predictor of improved disease-specific survival (HR = 0.42, CI 0.23–0.75, p = 0.004). Within different TNM-stages there was a tendency towards the same results, but with statistically significant results in stage II only (p = 0.007). High expression of miR-126 is an independent positive prognostic factor in stage I–III colon cancer. This finding may be used to identify patients in need of adjuvant chemotherapy.
format	article
author	Hallgeir Selven Lill-Tove Rasmussen Busund Sigve Andersen Roy M. Bremnes Thomas Karsten Kilvær
author_facet	Hallgeir Selven Lill-Tove Rasmussen Busund Sigve Andersen Roy M. Bremnes Thomas Karsten Kilvær
author_sort	Hallgeir Selven
title	High expression of microRNA-126 relates to favorable prognosis for colon cancer patients
title_short	High expression of microRNA-126 relates to favorable prognosis for colon cancer patients
title_full	High expression of microRNA-126 relates to favorable prognosis for colon cancer patients
title_fullStr	High expression of microRNA-126 relates to favorable prognosis for colon cancer patients
title_full_unstemmed	High expression of microRNA-126 relates to favorable prognosis for colon cancer patients
title_sort	high expression of microrna-126 relates to favorable prognosis for colon cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4afe9c4e77834484b4e5ef64578b98fd
work_keys_str_mv	AT hallgeirselven highexpressionofmicrorna126relatestofavorableprognosisforcoloncancerpatients AT lilltoverasmussenbusund highexpressionofmicrorna126relatestofavorableprognosisforcoloncancerpatients AT sigveandersen highexpressionofmicrorna126relatestofavorableprognosisforcoloncancerpatients AT roymbremnes highexpressionofmicrorna126relatestofavorableprognosisforcoloncancerpatients AT thomaskarstenkilvær highexpressionofmicrorna126relatestofavorableprognosisforcoloncancerpatients
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High expression of microRNA-126 relates to favorable prognosis for colon cancer patients

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