Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life

The role of stem/progenitor cell populations in mammary gland morphogenesis is not well understood. Here, the authors show that a transcriptional repressor, Blimp1, is expressed in a rare luminal stem cell population, which contribute to duct formation, and survive multiple rounds of pregnancy and i...

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Auteurs principaux:	Salah Elias, Marc A. Morgan, Elizabeth K. Bikoff, Elizabeth J. Robertson
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/4aff0135d8cd4c069ea5ad5641f3cb92
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id	oai:doaj.org-article:4aff0135d8cd4c069ea5ad5641f3cb92
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spelling	oai:doaj.org-article:4aff0135d8cd4c069ea5ad5641f3cb922021-12-02T13:27:22ZLong-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life10.1038/s41467-017-01971-w2041-1723https://doaj.org/article/4aff0135d8cd4c069ea5ad5641f3cb922017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01971-whttps://doaj.org/toc/2041-1723The role of stem/progenitor cell populations in mammary gland morphogenesis is not well understood. Here, the authors show that a transcriptional repressor, Blimp1, is expressed in a rare luminal stem cell population, which contribute to duct formation, and survive multiple rounds of pregnancy and involution.Salah EliasMarc A. MorganElizabeth K. BikoffElizabeth J. RobertsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Salah Elias Marc A. Morgan Elizabeth K. Bikoff Elizabeth J. Robertson Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life
description	The role of stem/progenitor cell populations in mammary gland morphogenesis is not well understood. Here, the authors show that a transcriptional repressor, Blimp1, is expressed in a rare luminal stem cell population, which contribute to duct formation, and survive multiple rounds of pregnancy and involution.
format	article
author	Salah Elias Marc A. Morgan Elizabeth K. Bikoff Elizabeth J. Robertson
author_facet	Salah Elias Marc A. Morgan Elizabeth K. Bikoff Elizabeth J. Robertson
author_sort	Salah Elias
title	Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life
title_short	Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life
title_full	Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life
title_fullStr	Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life
title_full_unstemmed	Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life
title_sort	long-lived unipotent blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4aff0135d8cd4c069ea5ad5641f3cb92
work_keys_str_mv	AT salahelias longlivedunipotentblimp1positiveluminalstemcellsdrivemammaryglandorganogenesisthroughoutadultlife AT marcamorgan longlivedunipotentblimp1positiveluminalstemcellsdrivemammaryglandorganogenesisthroughoutadultlife AT elizabethkbikoff longlivedunipotentblimp1positiveluminalstemcellsdrivemammaryglandorganogenesisthroughoutadultlife AT elizabethjrobertson longlivedunipotentblimp1positiveluminalstemcellsdrivemammaryglandorganogenesisthroughoutadultlife
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Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life

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