The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.

<h4>Purpose</h4>To analyze the association between glucosamine (GlcN) use and the risk of age-related macular degeneration (AMD) using claims data from the National Health Insurance Research Database (NHIRD).<h4>Methods</h4>A retrospective, population-based study was conducte...

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Autores principales:	Kathy Ming Feng, Wu-Chien Chien, Jiann-Torng Chen, Yi-Hao Chen, Chi-Hsiang Chung, Chien-An Sun, Ching-Long Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4aff22c858c8477ba79c23a270ce99d4
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spelling	oai:doaj.org-article:4aff22c858c8477ba79c23a270ce99d42021-12-02T20:11:17ZThe impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.1932-620310.1371/journal.pone.0251925https://doaj.org/article/4aff22c858c8477ba79c23a270ce99d42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251925https://doaj.org/toc/1932-6203<h4>Purpose</h4>To analyze the association between glucosamine (GlcN) use and the risk of age-related macular degeneration (AMD) using claims data from the National Health Insurance Research Database (NHIRD).<h4>Methods</h4>A retrospective, population-based study was conducted with NHIRD data from a 14-year period (2000-2013). Chi-squared and Student's t-tests were used to evaluate differences between the study and comparison cohorts for categorical and continuous variables, respectively. Risk factors for disease development were examined by the adjusted hazard ratio (aHR) with 95% confidence interval. Kaplan-Meier analysis was performed to compare the cumulative risk of AMD between the two cohorts.<h4>Results</h4>In total, 1,344 patients with GlcN treatment were enrolled in the study cohort and 5,376 patients without GlcN use were enrolled in the comparison cohort. The incidence rate of AMD was lower with GlcN use (3.65%) than without GlcN use (5.26%) (P = 0.014). GlcN use was associated with a lower risk of developing AMD among patients with hyperlipidemia, coronary artery disease, chronic obstructive pulmonary disease, stroke, other neurological disorders, or degenerative arthritis. Although the incidence of wet type AMD did not significantly differ (P = 0.91), the incidence of dry type AMD was lower in patients with GlcN use (2.9%) than those without GlcN use (4.84%) (P = 0.003). Kaplan-Meier analysis similarly revealed a lower rate of dry type AMD in patients with GlcN use compared to those without GlcN use (log-rank P = 0.004).<h4>Conclusions</h4>GlcN treatment can decrease the risk of developing dry type AMD. Further prospective controlled studies are needed to determine the effectiveness of GlcN treatment in patients with AMD and the associated mechanism.Kathy Ming FengWu-Chien ChienJiann-Torng ChenYi-Hao ChenChi-Hsiang ChungChien-An SunChing-Long ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251925 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kathy Ming Feng Wu-Chien Chien Jiann-Torng Chen Yi-Hao Chen Chi-Hsiang Chung Chien-An Sun Ching-Long Chen The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.
description	<h4>Purpose</h4>To analyze the association between glucosamine (GlcN) use and the risk of age-related macular degeneration (AMD) using claims data from the National Health Insurance Research Database (NHIRD).<h4>Methods</h4>A retrospective, population-based study was conducted with NHIRD data from a 14-year period (2000-2013). Chi-squared and Student's t-tests were used to evaluate differences between the study and comparison cohorts for categorical and continuous variables, respectively. Risk factors for disease development were examined by the adjusted hazard ratio (aHR) with 95% confidence interval. Kaplan-Meier analysis was performed to compare the cumulative risk of AMD between the two cohorts.<h4>Results</h4>In total, 1,344 patients with GlcN treatment were enrolled in the study cohort and 5,376 patients without GlcN use were enrolled in the comparison cohort. The incidence rate of AMD was lower with GlcN use (3.65%) than without GlcN use (5.26%) (P = 0.014). GlcN use was associated with a lower risk of developing AMD among patients with hyperlipidemia, coronary artery disease, chronic obstructive pulmonary disease, stroke, other neurological disorders, or degenerative arthritis. Although the incidence of wet type AMD did not significantly differ (P = 0.91), the incidence of dry type AMD was lower in patients with GlcN use (2.9%) than those without GlcN use (4.84%) (P = 0.003). Kaplan-Meier analysis similarly revealed a lower rate of dry type AMD in patients with GlcN use compared to those without GlcN use (log-rank P = 0.004).<h4>Conclusions</h4>GlcN treatment can decrease the risk of developing dry type AMD. Further prospective controlled studies are needed to determine the effectiveness of GlcN treatment in patients with AMD and the associated mechanism.
format	article
author	Kathy Ming Feng Wu-Chien Chien Jiann-Torng Chen Yi-Hao Chen Chi-Hsiang Chung Chien-An Sun Ching-Long Chen
author_facet	Kathy Ming Feng Wu-Chien Chien Jiann-Torng Chen Yi-Hao Chen Chi-Hsiang Chung Chien-An Sun Ching-Long Chen
author_sort	Kathy Ming Feng
title	The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.
title_short	The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.
title_full	The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.
title_fullStr	The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.
title_full_unstemmed	The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.
title_sort	impact of glucosamine on age-related macular degeneration in patients: a nationwide, population-based cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4aff22c858c8477ba79c23a270ce99d4
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The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.

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