The dynamic functional core network of the human brain at rest

Abstract The human brain is an inherently complex and dynamic system. Even at rest, functional brain networks dynamically reconfigure in a well-organized way to warrant an efficient communication between brain regions. However, a precise characterization of this reconfiguration at very fast time-sca...

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Autores principales: A. Kabbara, W. EL Falou, M. Khalil, F. Wendling, M. Hassan
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4b0020e4d14349f2bbc9b726b0c5c36d
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spelling oai:doaj.org-article:4b0020e4d14349f2bbc9b726b0c5c36d2021-12-02T11:53:13ZThe dynamic functional core network of the human brain at rest10.1038/s41598-017-03420-62045-2322https://doaj.org/article/4b0020e4d14349f2bbc9b726b0c5c36d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03420-6https://doaj.org/toc/2045-2322Abstract The human brain is an inherently complex and dynamic system. Even at rest, functional brain networks dynamically reconfigure in a well-organized way to warrant an efficient communication between brain regions. However, a precise characterization of this reconfiguration at very fast time-scale (hundreds of millisecond) during rest remains elusive. In this study, we used dense electroencephalography data recorded during task-free paradigm to track the fast temporal dynamics of spontaneous brain networks. Results obtained from network-based analysis methods revealed the existence of a functional dynamic core network formed of a set of key brain regions that ensure segregation and integration functions. Brain regions within this functional core share high betweenness centrality, strength and vulnerability (high impact on the network global efficiency) and low clustering coefficient. These regions are mainly located in the cingulate and the medial frontal cortex. In particular, most of the identified hubs were found to belong to the Default Mode Network. Results also revealed that the same central regions may dynamically alternate and play the role of either provincial (local) or connector (global) hubs.A. KabbaraW. EL FalouM. KhalilF. WendlingM. HassanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
A. Kabbara
W. EL Falou
M. Khalil
F. Wendling
M. Hassan
The dynamic functional core network of the human brain at rest
description Abstract The human brain is an inherently complex and dynamic system. Even at rest, functional brain networks dynamically reconfigure in a well-organized way to warrant an efficient communication between brain regions. However, a precise characterization of this reconfiguration at very fast time-scale (hundreds of millisecond) during rest remains elusive. In this study, we used dense electroencephalography data recorded during task-free paradigm to track the fast temporal dynamics of spontaneous brain networks. Results obtained from network-based analysis methods revealed the existence of a functional dynamic core network formed of a set of key brain regions that ensure segregation and integration functions. Brain regions within this functional core share high betweenness centrality, strength and vulnerability (high impact on the network global efficiency) and low clustering coefficient. These regions are mainly located in the cingulate and the medial frontal cortex. In particular, most of the identified hubs were found to belong to the Default Mode Network. Results also revealed that the same central regions may dynamically alternate and play the role of either provincial (local) or connector (global) hubs.
format article
author A. Kabbara
W. EL Falou
M. Khalil
F. Wendling
M. Hassan
author_facet A. Kabbara
W. EL Falou
M. Khalil
F. Wendling
M. Hassan
author_sort A. Kabbara
title The dynamic functional core network of the human brain at rest
title_short The dynamic functional core network of the human brain at rest
title_full The dynamic functional core network of the human brain at rest
title_fullStr The dynamic functional core network of the human brain at rest
title_full_unstemmed The dynamic functional core network of the human brain at rest
title_sort dynamic functional core network of the human brain at rest
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/4b0020e4d14349f2bbc9b726b0c5c36d
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