Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration

Purpose: To determine the relationship between plasma concentrations of the C-C chemokines CCL2, CCL3, CCL4, and CCL5 and intermediate age-related macular degeneration (iAMD) patients compared with control inidividuals to further define the inflammatory pathways associated with age-related macular d...

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Autores principales:	Alan G. Palestine, Brandie D. Wagner, Jennifer L. Patnaik, Rebecca Baldermann, Marc T. Mathias, Naresh Mandava, Anne M. Lynch
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	age-related macular degeneration inflammation chemokines CCL2 CCL3 CCL4 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4b00d67322864f23b045a41f084686c0
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spelling	oai:doaj.org-article:4b00d67322864f23b045a41f084686c02021-11-18T06:00:28ZPlasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration2296-858X10.3389/fmed.2021.710595https://doaj.org/article/4b00d67322864f23b045a41f084686c02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.710595/fullhttps://doaj.org/toc/2296-858XPurpose: To determine the relationship between plasma concentrations of the C-C chemokines CCL2, CCL3, CCL4, and CCL5 and intermediate age-related macular degeneration (iAMD) patients compared with control inidividuals to further define the inflammatory pathways associated with age-related macular degeneration.Methods: The concentrations of CCL2, CCL3, CCL4, and CCL5 were measured using multiplex assays in plasma collected from 210 patients with iAMD and 102 control individuals with no macular degeneration as defined by multi-modal imaging. Non-inflammatory data included in the analysis were: age, sex, family history of AMD, history of smoking, body mass index, presence of reticular pseudo-drusen and cardiovascular disease. Median concentrations as well as a cutoff value for each chemokine were compared between the two groups.Results: The median concentrations of CCL2 and CCL4 did not differ between control and iAMD groups, however, CCL2 was elevated in iAMD when a cutoff comparison was used (p < 0.05). Median CCL3 and CCL5 concentrations were significantly decreased in the macular degeneration group compared with controls (p < 0.001) as well as when a cutoff value comparison was used. CCL3 and CCL5 were negatively correlated in cases and positively correlated in controls.Conclusions: Plasma CCL3 and CCL5 concentrations were significantly decreased and CCL2 concentrations were increased in patients with iAMD compared with controls, suggesting a role for C-C chemokines in the systemic inflammatory processes associated with disease development.Alan G. PalestineBrandie D. WagnerBrandie D. WagnerJennifer L. PatnaikRebecca BaldermannMarc T. MathiasNaresh MandavaAnne M. LynchFrontiers Media S.A.articleage-related macular degenerationinflammationchemokinesCCL2CCL3CCL4Medicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	age-related macular degeneration inflammation chemokines CCL2 CCL3 CCL4 Medicine (General) R5-920
spellingShingle	age-related macular degeneration inflammation chemokines CCL2 CCL3 CCL4 Medicine (General) R5-920 Alan G. Palestine Brandie D. Wagner Brandie D. Wagner Jennifer L. Patnaik Rebecca Baldermann Marc T. Mathias Naresh Mandava Anne M. Lynch Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration
description	Purpose: To determine the relationship between plasma concentrations of the C-C chemokines CCL2, CCL3, CCL4, and CCL5 and intermediate age-related macular degeneration (iAMD) patients compared with control inidividuals to further define the inflammatory pathways associated with age-related macular degeneration.Methods: The concentrations of CCL2, CCL3, CCL4, and CCL5 were measured using multiplex assays in plasma collected from 210 patients with iAMD and 102 control individuals with no macular degeneration as defined by multi-modal imaging. Non-inflammatory data included in the analysis were: age, sex, family history of AMD, history of smoking, body mass index, presence of reticular pseudo-drusen and cardiovascular disease. Median concentrations as well as a cutoff value for each chemokine were compared between the two groups.Results: The median concentrations of CCL2 and CCL4 did not differ between control and iAMD groups, however, CCL2 was elevated in iAMD when a cutoff comparison was used (p < 0.05). Median CCL3 and CCL5 concentrations were significantly decreased in the macular degeneration group compared with controls (p < 0.001) as well as when a cutoff value comparison was used. CCL3 and CCL5 were negatively correlated in cases and positively correlated in controls.Conclusions: Plasma CCL3 and CCL5 concentrations were significantly decreased and CCL2 concentrations were increased in patients with iAMD compared with controls, suggesting a role for C-C chemokines in the systemic inflammatory processes associated with disease development.
format	article
author	Alan G. Palestine Brandie D. Wagner Brandie D. Wagner Jennifer L. Patnaik Rebecca Baldermann Marc T. Mathias Naresh Mandava Anne M. Lynch
author_facet	Alan G. Palestine Brandie D. Wagner Brandie D. Wagner Jennifer L. Patnaik Rebecca Baldermann Marc T. Mathias Naresh Mandava Anne M. Lynch
author_sort	Alan G. Palestine
title	Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration
title_short	Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration
title_full	Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration
title_fullStr	Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration
title_full_unstemmed	Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration
title_sort	plasma c-c chemokine concentrations in intermediate age-related macular degeneration
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4b00d67322864f23b045a41f084686c0
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Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration

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