Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse

Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse

Anterior vaginal prolapse (AVP), the most common form of pelvic organ prolapse, has deleterious effects on women’s health. Here the authors employ single-cell RNA-seq to construct a transcriptomic atlas of vaginal wall cells from AVP patients, and find that extracellular matrix dysregulation and imm...

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Autores principales: Yaqian Li, Qing-Yang Zhang, Bao-Fa Sun, Yidi Ma, Ye Zhang, Min Wang, Congcong Ma, Honghui Shi, Zhijing Sun, Juan Chen, Yun-Gui Yang, Lan Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4b0a3ef279214a6ab382df23c46f0f76
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spelling oai:doaj.org-article:4b0a3ef279214a6ab382df23c46f0f762021-12-02T11:56:18ZSingle-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse10.1038/s41467-020-20358-y2041-1723https://doaj.org/article/4b0a3ef279214a6ab382df23c46f0f762021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20358-yhttps://doaj.org/toc/2041-1723Anterior vaginal prolapse (AVP), the most common form of pelvic organ prolapse, has deleterious effects on women’s health. Here the authors employ single-cell RNA-seq to construct a transcriptomic atlas of vaginal wall cells from AVP patients, and find that extracellular matrix dysregulation and immune reaction are associated with AVP.Yaqian LiQing-Yang ZhangBao-Fa SunYidi MaYe ZhangMin WangCongcong MaHonghui ShiZhijing SunJuan ChenYun-Gui YangLan ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yaqian Li
Qing-Yang Zhang
Bao-Fa Sun
Yidi Ma
Ye Zhang
Min Wang
Congcong Ma
Honghui Shi
Zhijing Sun
Juan Chen
Yun-Gui Yang
Lan Zhu
Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
description Anterior vaginal prolapse (AVP), the most common form of pelvic organ prolapse, has deleterious effects on women’s health. Here the authors employ single-cell RNA-seq to construct a transcriptomic atlas of vaginal wall cells from AVP patients, and find that extracellular matrix dysregulation and immune reaction are associated with AVP.
format article
author Yaqian Li
Qing-Yang Zhang
Bao-Fa Sun
Yidi Ma
Ye Zhang
Min Wang
Congcong Ma
Honghui Shi
Zhijing Sun
Juan Chen
Yun-Gui Yang
Lan Zhu
author_facet Yaqian Li
Qing-Yang Zhang
Bao-Fa Sun
Yidi Ma
Ye Zhang
Min Wang
Congcong Ma
Honghui Shi
Zhijing Sun
Juan Chen
Yun-Gui Yang
Lan Zhu
author_sort Yaqian Li
title Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_short Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_full Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_fullStr Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_full_unstemmed Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_sort single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4b0a3ef279214a6ab382df23c46f0f76
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