Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse

Anterior vaginal prolapse (AVP), the most common form of pelvic organ prolapse, has deleterious effects on women’s health. Here the authors employ single-cell RNA-seq to construct a transcriptomic atlas of vaginal wall cells from AVP patients, and find that extracellular matrix dysregulation and imm...

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Auteurs principaux:	Yaqian Li, Qing-Yang Zhang, Bao-Fa Sun, Yidi Ma, Ye Zhang, Min Wang, Congcong Ma, Honghui Shi, Zhijing Sun, Juan Chen, Yun-Gui Yang, Lan Zhu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/4b0a3ef279214a6ab382df23c46f0f76
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spelling	oai:doaj.org-article:4b0a3ef279214a6ab382df23c46f0f762021-12-02T11:56:18ZSingle-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse10.1038/s41467-020-20358-y2041-1723https://doaj.org/article/4b0a3ef279214a6ab382df23c46f0f762021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20358-yhttps://doaj.org/toc/2041-1723Anterior vaginal prolapse (AVP), the most common form of pelvic organ prolapse, has deleterious effects on women’s health. Here the authors employ single-cell RNA-seq to construct a transcriptomic atlas of vaginal wall cells from AVP patients, and find that extracellular matrix dysregulation and immune reaction are associated with AVP.Yaqian LiQing-Yang ZhangBao-Fa SunYidi MaYe ZhangMin WangCongcong MaHonghui ShiZhijing SunJuan ChenYun-Gui YangLan ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yaqian Li Qing-Yang Zhang Bao-Fa Sun Yidi Ma Ye Zhang Min Wang Congcong Ma Honghui Shi Zhijing Sun Juan Chen Yun-Gui Yang Lan Zhu Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
description	Anterior vaginal prolapse (AVP), the most common form of pelvic organ prolapse, has deleterious effects on women’s health. Here the authors employ single-cell RNA-seq to construct a transcriptomic atlas of vaginal wall cells from AVP patients, and find that extracellular matrix dysregulation and immune reaction are associated with AVP.
format	article
author	Yaqian Li Qing-Yang Zhang Bao-Fa Sun Yidi Ma Ye Zhang Min Wang Congcong Ma Honghui Shi Zhijing Sun Juan Chen Yun-Gui Yang Lan Zhu
author_facet	Yaqian Li Qing-Yang Zhang Bao-Fa Sun Yidi Ma Ye Zhang Min Wang Congcong Ma Honghui Shi Zhijing Sun Juan Chen Yun-Gui Yang Lan Zhu
author_sort	Yaqian Li
title	Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_short	Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_full	Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_fullStr	Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_full_unstemmed	Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
title_sort	single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b0a3ef279214a6ab382df23c46f0f76
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Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse

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