Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins

S-acylation is the post-translational covalent attachment of fatty acids (FA) onto cysteines. Nuskova et al. find that exposure of cells to different FAs affects which FA is used to S-acylate GNAI proteins, thereby altering GNAI function and EGFR pathway activation, linking metabolism to signaling.

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Autores principales:	Hana Nůsková, Marina V. Serebryakova, Anna Ferrer-Caelles, Timo Sachsenheimer, Christian Lüchtenborg, Aubry K. Miller, Britta Brügger, Larisa V. Kordyukova, Aurelio A. Teleman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b0fd691c75d4839863523c31d666fda
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spelling	oai:doaj.org-article:4b0fd691c75d4839863523c31d666fda2021-12-02T18:46:58ZStearic acid blunts growth-factor signaling via oleoylation of GNAI proteins10.1038/s41467-021-24844-92041-1723https://doaj.org/article/4b0fd691c75d4839863523c31d666fda2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24844-9https://doaj.org/toc/2041-1723S-acylation is the post-translational covalent attachment of fatty acids (FA) onto cysteines. Nuskova et al. find that exposure of cells to different FAs affects which FA is used to S-acylate GNAI proteins, thereby altering GNAI function and EGFR pathway activation, linking metabolism to signaling.Hana NůskováMarina V. SerebryakovaAnna Ferrer-CaellesTimo SachsenheimerChristian LüchtenborgAubry K. MillerBritta BrüggerLarisa V. KordyukovaAurelio A. TelemanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hana Nůsková Marina V. Serebryakova Anna Ferrer-Caelles Timo Sachsenheimer Christian Lüchtenborg Aubry K. Miller Britta Brügger Larisa V. Kordyukova Aurelio A. Teleman Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
description	S-acylation is the post-translational covalent attachment of fatty acids (FA) onto cysteines. Nuskova et al. find that exposure of cells to different FAs affects which FA is used to S-acylate GNAI proteins, thereby altering GNAI function and EGFR pathway activation, linking metabolism to signaling.
format	article
author	Hana Nůsková Marina V. Serebryakova Anna Ferrer-Caelles Timo Sachsenheimer Christian Lüchtenborg Aubry K. Miller Britta Brügger Larisa V. Kordyukova Aurelio A. Teleman
author_facet	Hana Nůsková Marina V. Serebryakova Anna Ferrer-Caelles Timo Sachsenheimer Christian Lüchtenborg Aubry K. Miller Britta Brügger Larisa V. Kordyukova Aurelio A. Teleman
author_sort	Hana Nůsková
title	Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
title_short	Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
title_full	Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
title_fullStr	Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
title_full_unstemmed	Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
title_sort	stearic acid blunts growth-factor signaling via oleoylation of gnai proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b0fd691c75d4839863523c31d666fda
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Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins

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