Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins

Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins

S-acylation is the post-translational covalent attachment of fatty acids (FA) onto cysteines. Nuskova et al. find that exposure of cells to different FAs affects which FA is used to S-acylate GNAI proteins, thereby altering GNAI function and EGFR pathway activation, linking metabolism to signaling.

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Autores principales: Hana Nůsková, Marina V. Serebryakova, Anna Ferrer-Caelles, Timo Sachsenheimer, Christian Lüchtenborg, Aubry K. Miller, Britta Brügger, Larisa V. Kordyukova, Aurelio A. Teleman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/4b0fd691c75d4839863523c31d666fda
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