Fracture Risk Evaluation of Bone Metastases: A Burning Issue

Major progress has been achieved to treat cancer patients and survival has improved considerably, even for stage-IV bone metastatic patients. Locomotive health has become a crucial issue for patient autonomy and quality of life. The centerpiece of the reflection lies in the fracture risk evaluation...

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Autores principales:	Cyrille B. Confavreux, Helene Follet, David Mitton, Jean Baptiste Pialat, Philippe Clézardin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bone metastasis pathological fracture mirels’ score spinal instability neoplastic score finite element analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4b11a659f5084ca1bc956879d764d034
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spelling	oai:doaj.org-article:4b11a659f5084ca1bc956879d764d0342021-11-25T17:02:58ZFracture Risk Evaluation of Bone Metastases: A Burning Issue10.3390/cancers132257112072-6694https://doaj.org/article/4b11a659f5084ca1bc956879d764d0342021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5711https://doaj.org/toc/2072-6694Major progress has been achieved to treat cancer patients and survival has improved considerably, even for stage-IV bone metastatic patients. Locomotive health has become a crucial issue for patient autonomy and quality of life. The centerpiece of the reflection lies in the fracture risk evaluation of bone metastasis to guide physician decision regarding physical activity, antiresorptive agent prescription, and local intervention by radiotherapy, surgery, and interventional radiology. A key mandatory step, since bone metastases may be asymptomatic and disseminated throughout the skeleton, is to identify the bone metastasis location by cartography, especially within weight-bearing bones. For every location, the fracture risk evaluation relies on qualitative approaches using imagery and scores such as Mirels and spinal instability neoplastic score (SINS). This approach, however, has important limitations and there is a need to develop new tools for bone metastatic and myeloma fracture risk evaluation. Personalized numerical simulation qCT-based imaging constitutes one of these emerging tools to assess bone tumoral strength and estimate the femoral and vertebral fracture risk. The next generation of numerical simulation and artificial intelligence will take into account multiple loadings to integrate movement and obtain conditions even closer to real-life, in order to guide patient rehabilitation and activity within a personalized-medicine approach.Cyrille B. ConfavreuxHelene FolletDavid MittonJean Baptiste PialatPhilippe ClézardinMDPI AGarticlebone metastasispathological fracturemirels’ scorespinal instabilityneoplastic scorefinite element analysisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5711, p 5711 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone metastasis pathological fracture mirels’ score spinal instability neoplastic score finite element analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	bone metastasis pathological fracture mirels’ score spinal instability neoplastic score finite element analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cyrille B. Confavreux Helene Follet David Mitton Jean Baptiste Pialat Philippe Clézardin Fracture Risk Evaluation of Bone Metastases: A Burning Issue
description	Major progress has been achieved to treat cancer patients and survival has improved considerably, even for stage-IV bone metastatic patients. Locomotive health has become a crucial issue for patient autonomy and quality of life. The centerpiece of the reflection lies in the fracture risk evaluation of bone metastasis to guide physician decision regarding physical activity, antiresorptive agent prescription, and local intervention by radiotherapy, surgery, and interventional radiology. A key mandatory step, since bone metastases may be asymptomatic and disseminated throughout the skeleton, is to identify the bone metastasis location by cartography, especially within weight-bearing bones. For every location, the fracture risk evaluation relies on qualitative approaches using imagery and scores such as Mirels and spinal instability neoplastic score (SINS). This approach, however, has important limitations and there is a need to develop new tools for bone metastatic and myeloma fracture risk evaluation. Personalized numerical simulation qCT-based imaging constitutes one of these emerging tools to assess bone tumoral strength and estimate the femoral and vertebral fracture risk. The next generation of numerical simulation and artificial intelligence will take into account multiple loadings to integrate movement and obtain conditions even closer to real-life, in order to guide patient rehabilitation and activity within a personalized-medicine approach.
format	article
author	Cyrille B. Confavreux Helene Follet David Mitton Jean Baptiste Pialat Philippe Clézardin
author_facet	Cyrille B. Confavreux Helene Follet David Mitton Jean Baptiste Pialat Philippe Clézardin
author_sort	Cyrille B. Confavreux
title	Fracture Risk Evaluation of Bone Metastases: A Burning Issue
title_short	Fracture Risk Evaluation of Bone Metastases: A Burning Issue
title_full	Fracture Risk Evaluation of Bone Metastases: A Burning Issue
title_fullStr	Fracture Risk Evaluation of Bone Metastases: A Burning Issue
title_full_unstemmed	Fracture Risk Evaluation of Bone Metastases: A Burning Issue
title_sort	fracture risk evaluation of bone metastases: a burning issue
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4b11a659f5084ca1bc956879d764d034
work_keys_str_mv	AT cyrillebconfavreux fractureriskevaluationofbonemetastasesaburningissue AT helenefollet fractureriskevaluationofbonemetastasesaburningissue AT davidmitton fractureriskevaluationofbonemetastasesaburningissue AT jeanbaptistepialat fractureriskevaluationofbonemetastasesaburningissue AT philippeclezardin fractureriskevaluationofbonemetastasesaburningissue
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Fracture Risk Evaluation of Bone Metastases: A Burning Issue

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