Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Hydralazine is a drug used in the treatment of heart failure and cancer, and it has recently been shown to promote lifespan in C. elegans. Here, the authors elucidate the mechanism of action of hydralazine, and show that it targets PKA to promote mitochondrial function via Sirtuin1/5.

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Autores principales:	Esmaeil Dehghan, Mohammad Goodarzi, Bahar Saremi, Rueyling Lin, Hamid Mirzaei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b12837cbd2140e2bc27d0588d6f050c
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spelling	oai:doaj.org-article:4b12837cbd2140e2bc27d0588d6f050c2021-12-02T14:39:57ZHydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans10.1038/s41467-019-12425-w2041-1723https://doaj.org/article/4b12837cbd2140e2bc27d0588d6f050c2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12425-whttps://doaj.org/toc/2041-1723Hydralazine is a drug used in the treatment of heart failure and cancer, and it has recently been shown to promote lifespan in C. elegans. Here, the authors elucidate the mechanism of action of hydralazine, and show that it targets PKA to promote mitochondrial function via Sirtuin1/5.Esmaeil DehghanMohammad GoodarziBahar SaremiRueyling LinHamid MirzaeiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Esmaeil Dehghan Mohammad Goodarzi Bahar Saremi Rueyling Lin Hamid Mirzaei Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans
description	Hydralazine is a drug used in the treatment of heart failure and cancer, and it has recently been shown to promote lifespan in C. elegans. Here, the authors elucidate the mechanism of action of hydralazine, and show that it targets PKA to promote mitochondrial function via Sirtuin1/5.
format	article
author	Esmaeil Dehghan Mohammad Goodarzi Bahar Saremi Rueyling Lin Hamid Mirzaei
author_facet	Esmaeil Dehghan Mohammad Goodarzi Bahar Saremi Rueyling Lin Hamid Mirzaei
author_sort	Esmaeil Dehghan
title	Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans
title_short	Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans
title_full	Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans
title_fullStr	Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans
title_full_unstemmed	Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans
title_sort	hydralazine targets camp-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in c. elegans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4b12837cbd2140e2bc27d0588d6f050c
work_keys_str_mv	AT esmaeildehghan hydralazinetargetscampdependentproteinkinaseleadingtosirtuin15activationandlifespanextensionincelegans AT mohammadgoodarzi hydralazinetargetscampdependentproteinkinaseleadingtosirtuin15activationandlifespanextensionincelegans AT baharsaremi hydralazinetargetscampdependentproteinkinaseleadingtosirtuin15activationandlifespanextensionincelegans AT rueylinglin hydralazinetargetscampdependentproteinkinaseleadingtosirtuin15activationandlifespanextensionincelegans AT hamidmirzaei hydralazinetargetscampdependentproteinkinaseleadingtosirtuin15activationandlifespanextensionincelegans
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Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

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