A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain

A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain

Glycoprotein US9 of human cytomegalovirus downregulates the activating immune ligand MICA*008 to avoid NK cell activation. Here, Seidel et al. show that the signal peptide of US9 is cleaved unusually slowly, causing MICA*008 to be retained in the endoplasmic reticulum (ER) and degraded via the ER qu...

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Autores principales: Einat Seidel, Liat Dassa, Shira Kahlon, Boaz Tirosh, Anne Halenius, Tal Seidel Malkinson, Ofer Mandelboim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4b12a5f9952c4c4db91422b8ba6f827e
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spelling oai:doaj.org-article:4b12a5f9952c4c4db91422b8ba6f827e2021-12-02T18:15:27ZA slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain10.1038/s41467-021-21983-x2041-1723https://doaj.org/article/4b12a5f9952c4c4db91422b8ba6f827e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21983-xhttps://doaj.org/toc/2041-1723Glycoprotein US9 of human cytomegalovirus downregulates the activating immune ligand MICA*008 to avoid NK cell activation. Here, Seidel et al. show that the signal peptide of US9 is cleaved unusually slowly, causing MICA*008 to be retained in the endoplasmic reticulum (ER) and degraded via the ER quality control system.Einat SeidelLiat DassaShira KahlonBoaz TiroshAnne HaleniusTal Seidel MalkinsonOfer MandelboimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Einat Seidel
Liat Dassa
Shira Kahlon
Boaz Tirosh
Anne Halenius
Tal Seidel Malkinson
Ofer Mandelboim
A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
description Glycoprotein US9 of human cytomegalovirus downregulates the activating immune ligand MICA*008 to avoid NK cell activation. Here, Seidel et al. show that the signal peptide of US9 is cleaved unusually slowly, causing MICA*008 to be retained in the endoplasmic reticulum (ER) and degraded via the ER quality control system.
format article
author Einat Seidel
Liat Dassa
Shira Kahlon
Boaz Tirosh
Anne Halenius
Tal Seidel Malkinson
Ofer Mandelboim
author_facet Einat Seidel
Liat Dassa
Shira Kahlon
Boaz Tirosh
Anne Halenius
Tal Seidel Malkinson
Ofer Mandelboim
author_sort Einat Seidel
title A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
title_short A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
title_full A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
title_fullStr A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
title_full_unstemmed A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
title_sort slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4b12a5f9952c4c4db91422b8ba6f827e
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