Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community

Abstract The worldwide spread of E. coli ST131 has significantly contributed to the dissemination of E. coli producing extended-spectrum β-lactamases (ESBL). In a French University hospital, we assessed the molecular features of ESBL-producing E. coli and identified risk factors in patients for colo...

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Autores principales:	Allison Muller, Houssein Gbaguidi-Haore, Pascal Cholley, Didier Hocquet, Marlène Sauget, Xavier Bertrand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b12cdec1c894458bb10c868da792986
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spelling	oai:doaj.org-article:4b12cdec1c894458bb10c868da7929862021-12-02T13:34:46ZHospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community10.1038/s41598-021-85116-62045-2322https://doaj.org/article/4b12cdec1c894458bb10c868da7929862021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85116-6https://doaj.org/toc/2045-2322Abstract The worldwide spread of E. coli ST131 has significantly contributed to the dissemination of E. coli producing extended-spectrum β-lactamases (ESBL). In a French University hospital, we assessed the molecular features of ESBL-producing E. coli and identified risk factors in patients for colonization or infection with E. coli ST131. Over a 2-year period (2015–2017), each patient with at least one clinical isolate or one screening isolate positive with ESBL-producing E. coli were included (n = 491). The ST131 clonal group accounted for 17.5% (n = 86) of all ESBL-producing E. coli and represented 57.3% isolates of phylogroup B2. FimH-based sub-typing showed that 79.1% (68/86) of ST131 isolates were fimH30, among which 67.6% (n = 46), 20.6% (n = 14) and 11.8% (n = 8) isolates harbored genes encoding the ESBL CTX-M-15, CTX-M-27, and CTX-M-14, respectively. The multivariate analysis identified two factors independently associated with ST131 ESBL-producing E. coli isolates: infection (Odds ratio [OR] = 1.887, 95% confidence interval [CI]: 1.143–3.115; p = 0.013) and community acquisition (OR = 2.220, 95% CI: 1.335–3.693; p = 0.002). In conclusion, our study confirmed the predominance of ST131 clonal group among ESBL-producing E. coli and the difficulty to identify common risk factors associated with carriage of this pandemic clonal group.Allison MullerHoussein Gbaguidi-HaorePascal CholleyDidier HocquetMarlène SaugetXavier BertrandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Allison Muller Houssein Gbaguidi-Haore Pascal Cholley Didier Hocquet Marlène Sauget Xavier Bertrand Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community
description	Abstract The worldwide spread of E. coli ST131 has significantly contributed to the dissemination of E. coli producing extended-spectrum β-lactamases (ESBL). In a French University hospital, we assessed the molecular features of ESBL-producing E. coli and identified risk factors in patients for colonization or infection with E. coli ST131. Over a 2-year period (2015–2017), each patient with at least one clinical isolate or one screening isolate positive with ESBL-producing E. coli were included (n = 491). The ST131 clonal group accounted for 17.5% (n = 86) of all ESBL-producing E. coli and represented 57.3% isolates of phylogroup B2. FimH-based sub-typing showed that 79.1% (68/86) of ST131 isolates were fimH30, among which 67.6% (n = 46), 20.6% (n = 14) and 11.8% (n = 8) isolates harbored genes encoding the ESBL CTX-M-15, CTX-M-27, and CTX-M-14, respectively. The multivariate analysis identified two factors independently associated with ST131 ESBL-producing E. coli isolates: infection (Odds ratio [OR] = 1.887, 95% confidence interval [CI]: 1.143–3.115; p = 0.013) and community acquisition (OR = 2.220, 95% CI: 1.335–3.693; p = 0.002). In conclusion, our study confirmed the predominance of ST131 clonal group among ESBL-producing E. coli and the difficulty to identify common risk factors associated with carriage of this pandemic clonal group.
format	article
author	Allison Muller Houssein Gbaguidi-Haore Pascal Cholley Didier Hocquet Marlène Sauget Xavier Bertrand
author_facet	Allison Muller Houssein Gbaguidi-Haore Pascal Cholley Didier Hocquet Marlène Sauget Xavier Bertrand
author_sort	Allison Muller
title	Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community
title_short	Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community
title_full	Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community
title_fullStr	Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community
title_full_unstemmed	Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community
title_sort	hospital-diagnosed infections with escherichia coli clonal group st131 are mostly acquired in the community
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b12cdec1c894458bb10c868da792986
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Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community

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