Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG

Abstract Clinical diagnosis of epilepsy depends heavily on the detection of interictal epileptiform discharges (IEDs) from scalp electroencephalographic (EEG) signals, which by purely visual means is far from straightforward. Here, we introduce a simple signal analysis procedure based on scalp EEG z...

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Autores principales:	Jan Pyrzowski, Jean- Eudes Le Douget, Amal Fouad, Mariusz Siemiński, Joanna Jędrzejczak, Michel Le Van Quyen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b16c7d9e27b468a9331dd0e51ba0300
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spelling	oai:doaj.org-article:4b16c7d9e27b468a9331dd0e51ba03002021-12-02T14:21:42ZZero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG10.1038/s41598-021-83337-32045-2322https://doaj.org/article/4b16c7d9e27b468a9331dd0e51ba03002021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83337-3https://doaj.org/toc/2045-2322Abstract Clinical diagnosis of epilepsy depends heavily on the detection of interictal epileptiform discharges (IEDs) from scalp electroencephalographic (EEG) signals, which by purely visual means is far from straightforward. Here, we introduce a simple signal analysis procedure based on scalp EEG zero-crossing patterns which can extract the spatiotemporal structure of scalp voltage fluctuations. We analyzed simultaneous scalp and intracranial EEG recordings from patients with pharmacoresistant temporal lobe epilepsy. Our data show that a large proportion of intracranial IEDs manifest only as subtle, low-amplitude waveforms below scalp EEG background and could, therefore, not be detected visually. We found that scalp zero-crossing patterns allow detection of these intracranial IEDs on a single-trial level with millisecond temporal precision and including some mesial temporal discharges that do not propagate to the neocortex. Applied to an independent dataset, our method discriminated accurately between patients with epilepsy and normal subjects, confirming its practical applicability.Jan PyrzowskiJean- Eudes Le DougetAmal FouadMariusz SiemińskiJoanna JędrzejczakMichel Le Van QuyenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan Pyrzowski Jean- Eudes Le Douget Amal Fouad Mariusz Siemiński Joanna Jędrzejczak Michel Le Van Quyen Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG
description	Abstract Clinical diagnosis of epilepsy depends heavily on the detection of interictal epileptiform discharges (IEDs) from scalp electroencephalographic (EEG) signals, which by purely visual means is far from straightforward. Here, we introduce a simple signal analysis procedure based on scalp EEG zero-crossing patterns which can extract the spatiotemporal structure of scalp voltage fluctuations. We analyzed simultaneous scalp and intracranial EEG recordings from patients with pharmacoresistant temporal lobe epilepsy. Our data show that a large proportion of intracranial IEDs manifest only as subtle, low-amplitude waveforms below scalp EEG background and could, therefore, not be detected visually. We found that scalp zero-crossing patterns allow detection of these intracranial IEDs on a single-trial level with millisecond temporal precision and including some mesial temporal discharges that do not propagate to the neocortex. Applied to an independent dataset, our method discriminated accurately between patients with epilepsy and normal subjects, confirming its practical applicability.
format	article
author	Jan Pyrzowski Jean- Eudes Le Douget Amal Fouad Mariusz Siemiński Joanna Jędrzejczak Michel Le Van Quyen
author_facet	Jan Pyrzowski Jean- Eudes Le Douget Amal Fouad Mariusz Siemiński Joanna Jędrzejczak Michel Le Van Quyen
author_sort	Jan Pyrzowski
title	Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG
title_short	Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG
title_full	Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG
title_fullStr	Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG
title_full_unstemmed	Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG
title_sort	zero-crossing patterns reveal subtle epileptiform discharges in the scalp eeg
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b16c7d9e27b468a9331dd0e51ba0300
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Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG

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