Nationwide case–control study of risk factors and outcomes for community-acquired sepsis

Abstract Sepsis is the main cause of death in the intensive care units (ICU) and increasing incidences of ICU admissions for sepsis are reported. Identification of patients at risk for sepsis and poor outcome is therefore of outmost importance. We performed a nation-wide case–control study aiming at...

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Autores principales:	Ann-Charlotte Lindström, Mikael Eriksson, Johan Mårtensson, Anders Oldner, Emma Larsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b175b40aa2f42fda5e2512ee9163f8d
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spelling	oai:doaj.org-article:4b175b40aa2f42fda5e2512ee9163f8d2021-12-02T16:26:22ZNationwide case–control study of risk factors and outcomes for community-acquired sepsis10.1038/s41598-021-94558-x2045-2322https://doaj.org/article/4b175b40aa2f42fda5e2512ee9163f8d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94558-xhttps://doaj.org/toc/2045-2322Abstract Sepsis is the main cause of death in the intensive care units (ICU) and increasing incidences of ICU admissions for sepsis are reported. Identification of patients at risk for sepsis and poor outcome is therefore of outmost importance. We performed a nation-wide case–control study aiming at identifying and quantifying the association between co-morbidity and socio-economic factors with intensive care admission for community-acquired sepsis. We also explored 30-day mortality. All adult patients (n = 10,072) with sepsis admitted from an emergency department to an intensive care unit in Sweden between 2008 and 2017 and a control population (n = 50,322), matched on age, sex and county were included. In the sepsis group, 69% had a co-morbid condition at ICU admission, compared to 31% in the control group. Multivariable conditional logistic regression analysis was performed and there was a large variation in the influence of different risk factors associated with ICU-admission, renal disease, liver disease, metastatic malignancy, substance abuse, and congestive heart failure showed the strongest associations. Low income and low education level were more common in sepsis patients compared to controls. The adjusted OR for 30-day mortality for sepsis patients was 132 (95% CI 110–159) compared to controls.Ann-Charlotte LindströmMikael ErikssonJohan MårtenssonAnders OldnerEmma LarssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ann-Charlotte Lindström Mikael Eriksson Johan Mårtensson Anders Oldner Emma Larsson Nationwide case–control study of risk factors and outcomes for community-acquired sepsis
description	Abstract Sepsis is the main cause of death in the intensive care units (ICU) and increasing incidences of ICU admissions for sepsis are reported. Identification of patients at risk for sepsis and poor outcome is therefore of outmost importance. We performed a nation-wide case–control study aiming at identifying and quantifying the association between co-morbidity and socio-economic factors with intensive care admission for community-acquired sepsis. We also explored 30-day mortality. All adult patients (n = 10,072) with sepsis admitted from an emergency department to an intensive care unit in Sweden between 2008 and 2017 and a control population (n = 50,322), matched on age, sex and county were included. In the sepsis group, 69% had a co-morbid condition at ICU admission, compared to 31% in the control group. Multivariable conditional logistic regression analysis was performed and there was a large variation in the influence of different risk factors associated with ICU-admission, renal disease, liver disease, metastatic malignancy, substance abuse, and congestive heart failure showed the strongest associations. Low income and low education level were more common in sepsis patients compared to controls. The adjusted OR for 30-day mortality for sepsis patients was 132 (95% CI 110–159) compared to controls.
format	article
author	Ann-Charlotte Lindström Mikael Eriksson Johan Mårtensson Anders Oldner Emma Larsson
author_facet	Ann-Charlotte Lindström Mikael Eriksson Johan Mårtensson Anders Oldner Emma Larsson
author_sort	Ann-Charlotte Lindström
title	Nationwide case–control study of risk factors and outcomes for community-acquired sepsis
title_short	Nationwide case–control study of risk factors and outcomes for community-acquired sepsis
title_full	Nationwide case–control study of risk factors and outcomes for community-acquired sepsis
title_fullStr	Nationwide case–control study of risk factors and outcomes for community-acquired sepsis
title_full_unstemmed	Nationwide case–control study of risk factors and outcomes for community-acquired sepsis
title_sort	nationwide case–control study of risk factors and outcomes for community-acquired sepsis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b175b40aa2f42fda5e2512ee9163f8d
work_keys_str_mv	AT anncharlottelindstrom nationwidecasecontrolstudyofriskfactorsandoutcomesforcommunityacquiredsepsis AT mikaeleriksson nationwidecasecontrolstudyofriskfactorsandoutcomesforcommunityacquiredsepsis AT johanmartensson nationwidecasecontrolstudyofriskfactorsandoutcomesforcommunityacquiredsepsis AT andersoldner nationwidecasecontrolstudyofriskfactorsandoutcomesforcommunityacquiredsepsis AT emmalarsson nationwidecasecontrolstudyofriskfactorsandoutcomesforcommunityacquiredsepsis
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Nationwide case–control study of risk factors and outcomes for community-acquired sepsis

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