Cell Therapy: Types, Regulation, and Clinical Benefits

Cell therapy practices date back to the 19th century and continue to expand on investigational and investment grounds. Cell therapy includes stem cell- and non–stem cell-based, unicellular and multicellular therapies, with different immunophenotypic profiles, isolation techniques, mechanisms of acti...

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Autores principales:	Abed El-Hakim El-Kadiry, Moutih Rafei, Riam Shammaa
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cell therapy FDA regulations multicellular therapies regenerative medicine cancer immune diseases Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4b199b82483b4804886346411fff7906
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spelling	oai:doaj.org-article:4b199b82483b4804886346411fff79062021-11-22T05:56:18ZCell Therapy: Types, Regulation, and Clinical Benefits2296-858X10.3389/fmed.2021.756029https://doaj.org/article/4b199b82483b4804886346411fff79062021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.756029/fullhttps://doaj.org/toc/2296-858XCell therapy practices date back to the 19th century and continue to expand on investigational and investment grounds. Cell therapy includes stem cell- and non–stem cell-based, unicellular and multicellular therapies, with different immunophenotypic profiles, isolation techniques, mechanisms of action, and regulatory levels. Following the steps of their predecessor cell therapies that have become established or commercialized, investigational and premarket approval-exempt cell therapies continue to provide patients with promising therapeutic benefits in different disease areas. In this review article, we delineate the vast types of cell therapy, including stem cell-based and non–stem cell-based cell therapies, and create the first-in-literature compilation of the different “multicellular” therapies used in clinical settings. Besides providing the nuts and bolts of FDA policies regulating their use, we discuss the benefits of cell therapies reported in 3 therapeutic areas—regenerative medicine, immune diseases, and cancer. Finally, we contemplate the recent attention shift toward combined therapy approaches, highlighting the factors that render multicellular therapies a more attractive option than their unicellular counterparts.Abed El-Hakim El-KadiryAbed El-Hakim El-KadiryMoutih RafeiMoutih RafeiMoutih RafeiMoutih RafeiRiam ShammaaRiam ShammaaFrontiers Media S.A.articlecell therapyFDA regulationsmulticellular therapiesregenerative medicinecancerimmune diseasesMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell therapy FDA regulations multicellular therapies regenerative medicine cancer immune diseases Medicine (General) R5-920
spellingShingle	cell therapy FDA regulations multicellular therapies regenerative medicine cancer immune diseases Medicine (General) R5-920 Abed El-Hakim El-Kadiry Abed El-Hakim El-Kadiry Moutih Rafei Moutih Rafei Moutih Rafei Moutih Rafei Riam Shammaa Riam Shammaa Cell Therapy: Types, Regulation, and Clinical Benefits
description	Cell therapy practices date back to the 19th century and continue to expand on investigational and investment grounds. Cell therapy includes stem cell- and non–stem cell-based, unicellular and multicellular therapies, with different immunophenotypic profiles, isolation techniques, mechanisms of action, and regulatory levels. Following the steps of their predecessor cell therapies that have become established or commercialized, investigational and premarket approval-exempt cell therapies continue to provide patients with promising therapeutic benefits in different disease areas. In this review article, we delineate the vast types of cell therapy, including stem cell-based and non–stem cell-based cell therapies, and create the first-in-literature compilation of the different “multicellular” therapies used in clinical settings. Besides providing the nuts and bolts of FDA policies regulating their use, we discuss the benefits of cell therapies reported in 3 therapeutic areas—regenerative medicine, immune diseases, and cancer. Finally, we contemplate the recent attention shift toward combined therapy approaches, highlighting the factors that render multicellular therapies a more attractive option than their unicellular counterparts.
format	article
author	Abed El-Hakim El-Kadiry Abed El-Hakim El-Kadiry Moutih Rafei Moutih Rafei Moutih Rafei Moutih Rafei Riam Shammaa Riam Shammaa
author_facet	Abed El-Hakim El-Kadiry Abed El-Hakim El-Kadiry Moutih Rafei Moutih Rafei Moutih Rafei Moutih Rafei Riam Shammaa Riam Shammaa
author_sort	Abed El-Hakim El-Kadiry
title	Cell Therapy: Types, Regulation, and Clinical Benefits
title_short	Cell Therapy: Types, Regulation, and Clinical Benefits
title_full	Cell Therapy: Types, Regulation, and Clinical Benefits
title_fullStr	Cell Therapy: Types, Regulation, and Clinical Benefits
title_full_unstemmed	Cell Therapy: Types, Regulation, and Clinical Benefits
title_sort	cell therapy: types, regulation, and clinical benefits
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4b199b82483b4804886346411fff7906
work_keys_str_mv	AT abedelhakimelkadiry celltherapytypesregulationandclinicalbenefits AT abedelhakimelkadiry celltherapytypesregulationandclinicalbenefits AT moutihrafei celltherapytypesregulationandclinicalbenefits AT moutihrafei celltherapytypesregulationandclinicalbenefits AT moutihrafei celltherapytypesregulationandclinicalbenefits AT moutihrafei celltherapytypesregulationandclinicalbenefits AT riamshammaa celltherapytypesregulationandclinicalbenefits AT riamshammaa celltherapytypesregulationandclinicalbenefits
_version_	1718418100353761280

Cell Therapy: Types, Regulation, and Clinical Benefits

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