The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site

CcrM is a cell cycle-regulated DNA methyltransferase that methylates an adenine within a specific sequence following replication in the gram negative bacterium Caulobacter crescentus. Here the authors present a crystal structure of DNA-bound CcrM that reveals the molecular mechanism leading to seque...

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Autores principales: John R. Horton, Clayton B. Woodcock, Sifa B. Opot, Norbert O. Reich, Xing Zhang, Xiaodong Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4b19d54306f64a6a987f9f163c1d7c87
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Sumario:CcrM is a cell cycle-regulated DNA methyltransferase that methylates an adenine within a specific sequence following replication in the gram negative bacterium Caulobacter crescentus. Here the authors present a crystal structure of DNA-bound CcrM that reveals the molecular mechanism leading to sequence-specific methylation.