Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

Brain microglial cells can be replenished by blood-derived monocytes, but many aspects of this repopulation remain unclear. Here the authors show that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6Chi monocytes, with the latter h...

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Autores principales:	Harald Lund, Melanie Pieber, Roham Parsa, Jinming Han, David Grommisch, Ewoud Ewing, Lara Kular, Maria Needhamsen, Alexander Espinosa, Emma Nilsson, Anna K. Överby, Oleg Butovsky, Maja Jagodic, Xing-Mei Zhang, Robert A. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b205c6e06da4bc4a5c5e12d39863140
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spelling	oai:doaj.org-article:4b205c6e06da4bc4a5c5e12d398631402021-12-02T16:49:34ZCompetitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells10.1038/s41467-018-07295-72041-1723https://doaj.org/article/4b205c6e06da4bc4a5c5e12d398631402018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07295-7https://doaj.org/toc/2041-1723Brain microglial cells can be replenished by blood-derived monocytes, but many aspects of this repopulation remain unclear. Here the authors show that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6Chi monocytes, with the latter having overlapping but distinct characteristics.Harald LundMelanie PieberRoham ParsaJinming HanDavid GrommischEwoud EwingLara KularMaria NeedhamsenAlexander EspinosaEmma NilssonAnna K. ÖverbyOleg ButovskyMaja JagodicXing-Mei ZhangRobert A. HarrisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Harald Lund Melanie Pieber Roham Parsa Jinming Han David Grommisch Ewoud Ewing Lara Kular Maria Needhamsen Alexander Espinosa Emma Nilsson Anna K. Överby Oleg Butovsky Maja Jagodic Xing-Mei Zhang Robert A. Harris Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
description	Brain microglial cells can be replenished by blood-derived monocytes, but many aspects of this repopulation remain unclear. Here the authors show that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6Chi monocytes, with the latter having overlapping but distinct characteristics.
format	article
author	Harald Lund Melanie Pieber Roham Parsa Jinming Han David Grommisch Ewoud Ewing Lara Kular Maria Needhamsen Alexander Espinosa Emma Nilsson Anna K. Överby Oleg Butovsky Maja Jagodic Xing-Mei Zhang Robert A. Harris
author_facet	Harald Lund Melanie Pieber Roham Parsa Jinming Han David Grommisch Ewoud Ewing Lara Kular Maria Needhamsen Alexander Espinosa Emma Nilsson Anna K. Överby Oleg Butovsky Maja Jagodic Xing-Mei Zhang Robert A. Harris
author_sort	Harald Lund
title	Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
title_short	Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
title_full	Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
title_fullStr	Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
title_full_unstemmed	Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
title_sort	competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4b205c6e06da4bc4a5c5e12d39863140
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Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

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