Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II
Heterozygous loss of chromosome 17p is a common genomic event in castration-resistant prostate cancers (CRPC). Here, the authors use CRISPR-based screen to identify RBX1 as a target gene for CRPC with 17p loss and targeting RBX1 sensitizes CRPC to the treatment of α-amanitin antibody conjugates.
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Nature Portfolio
2018
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oai:doaj.org-article:4b210d41ca154f21b5a6e78a1b6ae6c92021-12-02T14:40:54ZHeterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II10.1038/s41467-018-06811-z2041-1723https://doaj.org/article/4b210d41ca154f21b5a6e78a1b6ae6c92018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06811-zhttps://doaj.org/toc/2041-1723Heterozygous loss of chromosome 17p is a common genomic event in castration-resistant prostate cancers (CRPC). Here, the authors use CRISPR-based screen to identify RBX1 as a target gene for CRPC with 17p loss and targeting RBX1 sensitizes CRPC to the treatment of α-amanitin antibody conjugates.Yujing LiYunhua LiuHanchen XuGuanglong JiangKevin Van der JeughtYuanzhang FangZhuolong ZhouLu ZhangMichael FriedenLifei WangZhenhua LuoMilan RadovichBryan P. SchneiderYibin DengYunlong LiuKun HuangBin HeJin WangXiaoming HeXinna ZhangGuang JiXiongbin LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yujing Li Yunhua Liu Hanchen Xu Guanglong Jiang Kevin Van der Jeught Yuanzhang Fang Zhuolong Zhou Lu Zhang Michael Frieden Lifei Wang Zhenhua Luo Milan Radovich Bryan P. Schneider Yibin Deng Yunlong Liu Kun Huang Bin He Jin Wang Xiaoming He Xinna Zhang Guang Ji Xiongbin Lu Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II |
| description |
Heterozygous loss of chromosome 17p is a common genomic event in castration-resistant prostate cancers (CRPC). Here, the authors use CRISPR-based screen to identify RBX1 as a target gene for CRPC with 17p loss and targeting RBX1 sensitizes CRPC to the treatment of α-amanitin antibody conjugates. |
| format |
article |
| author |
Yujing Li Yunhua Liu Hanchen Xu Guanglong Jiang Kevin Van der Jeught Yuanzhang Fang Zhuolong Zhou Lu Zhang Michael Frieden Lifei Wang Zhenhua Luo Milan Radovich Bryan P. Schneider Yibin Deng Yunlong Liu Kun Huang Bin He Jin Wang Xiaoming He Xinna Zhang Guang Ji Xiongbin Lu |
| author_facet |
Yujing Li Yunhua Liu Hanchen Xu Guanglong Jiang Kevin Van der Jeught Yuanzhang Fang Zhuolong Zhou Lu Zhang Michael Frieden Lifei Wang Zhenhua Luo Milan Radovich Bryan P. Schneider Yibin Deng Yunlong Liu Kun Huang Bin He Jin Wang Xiaoming He Xinna Zhang Guang Ji Xiongbin Lu |
| author_sort |
Yujing Li |
| title |
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II |
| title_short |
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II |
| title_full |
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II |
| title_fullStr |
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II |
| title_full_unstemmed |
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II |
| title_sort |
heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of rna polymerase ii |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/4b210d41ca154f21b5a6e78a1b6ae6c9 |
| work_keys_str_mv |
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