Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis

Abstract Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are associated with the severity of various diseases. The aim of this study was to demonstrate the relationship of NLR and MLR with the severity of myocarditis. 202 consecutive patients with myocarditis were retrosp...

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Autores principales:	Moritz Mirna, Lukas Schmutzler, Albert Topf, Uta C. Hoppe, Michael Lichtenauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b21f55e2e194896a438cf8f6b9215d6
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spelling	oai:doaj.org-article:4b21f55e2e194896a438cf8f6b9215d62021-12-02T17:24:02ZNeutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis10.1038/s41598-021-97678-62045-2322https://doaj.org/article/4b21f55e2e194896a438cf8f6b9215d62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97678-6https://doaj.org/toc/2045-2322Abstract Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are associated with the severity of various diseases. The aim of this study was to demonstrate the relationship of NLR and MLR with the severity of myocarditis. 202 consecutive patients with myocarditis were retrospectively enrolled in this study. Laboratory parameters and clinical data were extracted from hospital records and discharge letters. Median NLR was 2.48 (IQR 1.55–4.58) and median MLR was 0.42 (IQR 0.39–0.58). NLR and MLR correlated with HF, CRP and leukocyte count, MLR further correlated inversely with LV systolic function (rs = − 0.379, p = 0.030). Both ratios correlated better with length of hospital stay (NLR: rs = 0.435, p = 0.003; MLR: rs = 0.534, p < 0.0001) than CRP, leukocyte count, IL-6 or procalcitonin. AUCs for the prediction of prolonged hospital stay (NLR = 0.75, MLR = 0.80), and optimal cut-offs therefor were calculated. Patients who had in-hospital complications showed a higher NLR, however, this remained statistically insignificant. NLR and MLR correlated with the length of stay, as well as with several clinical and laboratory parameters in patients with myocarditis. Since white blood cell differentials are relatively easy and fast to perform, both ratios could facilitate further risk stratification in affected patients.Moritz MirnaLukas SchmutzlerAlbert TopfUta C. HoppeMichael LichtenauerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moritz Mirna Lukas Schmutzler Albert Topf Uta C. Hoppe Michael Lichtenauer Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis
description	Abstract Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are associated with the severity of various diseases. The aim of this study was to demonstrate the relationship of NLR and MLR with the severity of myocarditis. 202 consecutive patients with myocarditis were retrospectively enrolled in this study. Laboratory parameters and clinical data were extracted from hospital records and discharge letters. Median NLR was 2.48 (IQR 1.55–4.58) and median MLR was 0.42 (IQR 0.39–0.58). NLR and MLR correlated with HF, CRP and leukocyte count, MLR further correlated inversely with LV systolic function (rs = − 0.379, p = 0.030). Both ratios correlated better with length of hospital stay (NLR: rs = 0.435, p = 0.003; MLR: rs = 0.534, p < 0.0001) than CRP, leukocyte count, IL-6 or procalcitonin. AUCs for the prediction of prolonged hospital stay (NLR = 0.75, MLR = 0.80), and optimal cut-offs therefor were calculated. Patients who had in-hospital complications showed a higher NLR, however, this remained statistically insignificant. NLR and MLR correlated with the length of stay, as well as with several clinical and laboratory parameters in patients with myocarditis. Since white blood cell differentials are relatively easy and fast to perform, both ratios could facilitate further risk stratification in affected patients.
format	article
author	Moritz Mirna Lukas Schmutzler Albert Topf Uta C. Hoppe Michael Lichtenauer
author_facet	Moritz Mirna Lukas Schmutzler Albert Topf Uta C. Hoppe Michael Lichtenauer
author_sort	Moritz Mirna
title	Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis
title_short	Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis
title_full	Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis
title_fullStr	Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis
title_full_unstemmed	Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis
title_sort	neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b21f55e2e194896a438cf8f6b9215d6
work_keys_str_mv	AT moritzmirna neutrophiltolymphocyteratioandmonocytetolymphocyteratiopredictlengthofhospitalstayinmyocarditis AT lukasschmutzler neutrophiltolymphocyteratioandmonocytetolymphocyteratiopredictlengthofhospitalstayinmyocarditis AT alberttopf neutrophiltolymphocyteratioandmonocytetolymphocyteratiopredictlengthofhospitalstayinmyocarditis AT utachoppe neutrophiltolymphocyteratioandmonocytetolymphocyteratiopredictlengthofhospitalstayinmyocarditis AT michaellichtenauer neutrophiltolymphocyteratioandmonocytetolymphocyteratiopredictlengthofhospitalstayinmyocarditis
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Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis

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