New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing

Among the most common complications of both chronic wound and surgical sites are staphylococcal skin infections, which slow down the wound healing process due to various virulence factors, including the ability to produce biofilms. Furthermore, staphylococcal skin infections are often caused by meth...

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Autores principales:	Oriana Simonetti, Giulio Rizzetto, Giulia Radi, Elisa Molinelli, Oscar Cirioni, Andrea Giacometti, Annamaria Offidani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial molecules wound healing staphylococcal skin infection Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/4b256d1e42c94a84a81b263deaf9b13b
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id	oai:doaj.org-article:4b256d1e42c94a84a81b263deaf9b13b
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spelling	oai:doaj.org-article:4b256d1e42c94a84a81b263deaf9b13b2021-11-25T16:24:18ZNew Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing10.3390/antibiotics101113772079-6382https://doaj.org/article/4b256d1e42c94a84a81b263deaf9b13b2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1377https://doaj.org/toc/2079-6382Among the most common complications of both chronic wound and surgical sites are staphylococcal skin infections, which slow down the wound healing process due to various virulence factors, including the ability to produce biofilms. Furthermore, staphylococcal skin infections are often caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and become a therapeutic challenge. The aim of this narrative review is to collect the latest evidence on old and new anti-staphylococcal therapies, assessing their anti-biofilm properties and their effect on skin wound healing. We considered antibiotics, quorum sensing inhibitors, antimicrobial peptides, topical dressings, and antimicrobial photo-dynamic therapy. According to our review of the literature, targeting of biofilm is an important therapeutic choice in acute and chronic infected skin wounds both to overcome antibiotic resistance and to achieve better wound healing.Oriana SimonettiGiulio RizzettoGiulia RadiElisa MolinelliOscar CirioniAndrea GiacomettiAnnamaria OffidaniMDPI AGarticleantimicrobial moleculeswound healingstaphylococcal skin infectionTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1377, p 1377 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial molecules wound healing staphylococcal skin infection Therapeutics. Pharmacology RM1-950
spellingShingle	antimicrobial molecules wound healing staphylococcal skin infection Therapeutics. Pharmacology RM1-950 Oriana Simonetti Giulio Rizzetto Giulia Radi Elisa Molinelli Oscar Cirioni Andrea Giacometti Annamaria Offidani New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing
description	Among the most common complications of both chronic wound and surgical sites are staphylococcal skin infections, which slow down the wound healing process due to various virulence factors, including the ability to produce biofilms. Furthermore, staphylococcal skin infections are often caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and become a therapeutic challenge. The aim of this narrative review is to collect the latest evidence on old and new anti-staphylococcal therapies, assessing their anti-biofilm properties and their effect on skin wound healing. We considered antibiotics, quorum sensing inhibitors, antimicrobial peptides, topical dressings, and antimicrobial photo-dynamic therapy. According to our review of the literature, targeting of biofilm is an important therapeutic choice in acute and chronic infected skin wounds both to overcome antibiotic resistance and to achieve better wound healing.
format	article
author	Oriana Simonetti Giulio Rizzetto Giulia Radi Elisa Molinelli Oscar Cirioni Andrea Giacometti Annamaria Offidani
author_facet	Oriana Simonetti Giulio Rizzetto Giulia Radi Elisa Molinelli Oscar Cirioni Andrea Giacometti Annamaria Offidani
author_sort	Oriana Simonetti
title	New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing
title_short	New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing
title_full	New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing
title_fullStr	New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing
title_full_unstemmed	New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing
title_sort	new perspectives on old and new therapies of staphylococcal skin infections: the role of biofilm targeting in wound healing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4b256d1e42c94a84a81b263deaf9b13b
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New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing

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