FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth

Disease stress-induced cardiac hypertrophy is a major mechanism of pathological cardiac remodeling. Here, the authors unveil a previously unrecognized role of a FoxO1–Dio2 signaling axis in maladaptive, afterload-induced cardiac hypertrophy and intracellular thyroid hormone homeostasis.

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Autores principales:	Anwarul Ferdous, Zhao V. Wang, Yuxuan Luo, Dan L. Li, Xiang Luo, Gabriele G. Schiattarella, Francisco Altamirano, Herman I. May, Pavan K. Battiprolu, Annie Nguyen, Beverly A. Rothermel, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b2c04dadb0144189152d9d80c25efb4
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spelling	oai:doaj.org-article:4b2c04dadb0144189152d9d80c25efb42021-12-02T15:45:30ZFoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth10.1038/s41467-020-16345-y2041-1723https://doaj.org/article/4b2c04dadb0144189152d9d80c25efb42020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16345-yhttps://doaj.org/toc/2041-1723Disease stress-induced cardiac hypertrophy is a major mechanism of pathological cardiac remodeling. Here, the authors unveil a previously unrecognized role of a FoxO1–Dio2 signaling axis in maladaptive, afterload-induced cardiac hypertrophy and intracellular thyroid hormone homeostasis.Anwarul FerdousZhao V. WangYuxuan LuoDan L. LiXiang LuoGabriele G. SchiattarellaFrancisco AltamiranoHerman I. MayPavan K. BattiproluAnnie NguyenBeverly A. RothermelSergio LavanderoThomas G. GilletteJoseph A. HillNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anwarul Ferdous Zhao V. Wang Yuxuan Luo Dan L. Li Xiang Luo Gabriele G. Schiattarella Francisco Altamirano Herman I. May Pavan K. Battiprolu Annie Nguyen Beverly A. Rothermel Sergio Lavandero Thomas G. Gillette Joseph A. Hill FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
description	Disease stress-induced cardiac hypertrophy is a major mechanism of pathological cardiac remodeling. Here, the authors unveil a previously unrecognized role of a FoxO1–Dio2 signaling axis in maladaptive, afterload-induced cardiac hypertrophy and intracellular thyroid hormone homeostasis.
format	article
author	Anwarul Ferdous Zhao V. Wang Yuxuan Luo Dan L. Li Xiang Luo Gabriele G. Schiattarella Francisco Altamirano Herman I. May Pavan K. Battiprolu Annie Nguyen Beverly A. Rothermel Sergio Lavandero Thomas G. Gillette Joseph A. Hill
author_facet	Anwarul Ferdous Zhao V. Wang Yuxuan Luo Dan L. Li Xiang Luo Gabriele G. Schiattarella Francisco Altamirano Herman I. May Pavan K. Battiprolu Annie Nguyen Beverly A. Rothermel Sergio Lavandero Thomas G. Gillette Joseph A. Hill
author_sort	Anwarul Ferdous
title	FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
title_short	FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
title_full	FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
title_fullStr	FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
title_full_unstemmed	FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
title_sort	foxo1–dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4b2c04dadb0144189152d9d80c25efb4
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FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth

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